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951.
XIANG Fang -fang CAO Xue -sen XU Shao -wei SHEN Bo ZOU Jian -zhou TENG Jie DING Xiao -qiang. 《中华肾脏病杂志》2013,29(8):589-594
ObjectiveTo investigate the association between peripheral white blood cell count including its subtypes and cardiovascular disease (CVD) incidence and one-year all-cause mortality in maintenance hemodialysis (MHD) patients. MethodsA total of 371 MHD patients at Zhongshan Hospital, Fudan University between March 2009 and February, 2011 were enrolled. Demographic, hematological, nutritional and inflammatory markers were obtained. All patients were followed for one year to investigate the risks for CVD event and mortality. Spearman correlation and linear regression were used to assess the relationship between white blood cell count and other laboratory parameters. Difference in categorical factors between two groups were determined with Chi-square test, Difference in continuous values between two groups were assessed with t test. Kaplan - Meier analysis and Cox proportional hazards model were applied to assess one-year mortality predictors. ResultsPatients with CVD event had lower lymphocyte count level (1.17±0.38 vs 1.34±0.51, P<0.05) and higher monocyte count level (0.44 ± 0.15 vs 0.37 ± 0.15, P<0.01) than those without CVD event. Cox proportional hazard regression showed that an increased lymphocyte count was associated with reduced mortality risk, 95%CI: 0.136-0.719, P<0.01) and that an increased monocyte count was associated with increased mortality risk, 95% CI: 2.657 - 74.396, P<0.01) after adjustment for hsCRP. ConclusionDecreased lymphocyte level and increased monocyte level are significantly related to CVD event and are independent predictors of increased one - year all - cause mortality risk in MHD patients. 相似文献
952.
953.
Rebecca L. Mather Abhijit Parolia Sandra E. Carson Erik Venalainen David RoigCarles Mustapha Jaber ShihChun Chu Ilaria Alborelli Rebecca Wu Dong Lin Noushin Nabavi Elena Jachetti Mario P. Colombo Hui Xue Perla Pucci Xinpei Ci Cheryl Hawkes Yinglei Li Hardev Pandha Igor Ulitsky Crystal Marconett Luca Quagliata Wei Jiang Ignacio Romero Yuzhuo Wang Francesco Crea 《Molecular oncology》2021,15(7):1921
954.
【摘要】目的 探讨阿仑膦酸钠与鲑鱼降钙素对椎间融合临床疗效的差异。方法 回顾性分析我科自2010年9月~2012年8月间治疗168例腰椎管狭窄合并腰椎间盘突出症患者资料,所有患者均行椎弓根螺钉固定、后路椎间融合术。依照PLIF术后用药的不同将患者机分为阿仑膦酸钠组(A组,n=51),鲑鱼降钙素组(B组,n=52)和对照组(C组,n=65,不使用任何抗骨质疏松及补钙药物)。比较患者的基本情况、临床效果和影像学结果(融合率和手术节段椎间隙高度的变化)。结果 术后随访半年~2年1个月,平均18个月。A、B、C组三组的优良率分别为88.2%、88.5%、61.5%,A、B组优良率均较对照组明显提高,但A、B组间优良率差异无显著性意义;A组和B组在手术时间、失血量以及住院时间上差异也无显著性。术后1年随访时融合率A组为84.3%,B组84.6%,C组53.8%,A、B组均高于C组,A、B组间比较差异无显著性意义。三组患者术后椎间隙高度均有不同程度的丢失,A组1.1 (0.6~1.9)mm、B组1.1 (0.8~2.1) mm,两组间比较差异无显著性意义,但A、B组椎间隙高度丢失程度均较对照组C组4.0 (1.9~4.9) mm明显降低。结论 腰椎后路椎间融合术(PLIF)术后规范使用阿仑膦酸钠或鲑鱼降钙素能够获得令人满意的临床效果,具有较高的椎间植骨融合率及较少的椎间隙高度丢失。 相似文献
955.
956.
Sevgi Gurkan Billie Fyfe Lynne Weiss Xue Xiao Yuzhou Zhang Richard J. Smith 《Pediatric nephrology (Berlin, Germany)》2013,28(10):1975-1981
Background
Hyperactivity of the alternative complement pathway is the principle defect in C3 glomerulopathies (C3G). Eculizumab, a monoclonal antibody that binds C5 to prevent formation of the membrane attack complex, has been shown to be beneficial in some patients with this disease.Methods
In this open-label, proof-of-concept efficacy-and-safety study, a patient with the initial diagnosis of dense deposit disease (DDD) and allograft recurrence of C3 glomerulonephritis (C3GN) was treated with eculizumab every other week for 1 year. The patient had pathological evidence of C3GN and proteinuria >1 g/day at enrollment. He underwent graft biopsy before enrollment and repeat biopsy at 6 and 12 months.Results
Although no mutations were identified in complement genes, functional studies were positive for C3 nephritic factors and elevated levels of soluble membrane attack complex (sMAC). On therapy, sMAC levels normalized and although proteinuria initially decreased, it increased reaching pre-treatment levels at 12 months. Although serum creatinine remained stable, repeat allograft biopsies showed progression of disease.Conclusions
Clinical and histopathologic data suggest a partial response to eculizumab in this patient. While eculizumab blocked activation of the terminal complement cascade, persistent dysregulation of the alternative pathway remained, indicating eculizumab alone cannot control disease in this patient. Additional research is required to identify effective anticomplement therapy for this group of C3G patients. 相似文献957.
Xi Yang Qi Chen Limin Liu Yueming Song Qingquan Kong Jiancheng Zeng Youdi Xue Chunpeng Ren 《International orthopaedics》2013,37(12):2421-2427
Purpose
The titanium mesh cage (TMC) is a typical metal cage device which has been widely used in cervical reconstruction for decades. Nano-hydroxyapatite/polyamide-66 (n-HA/PA66) cage is a novel biomimetic non-metal cage device growing in popularity in many medical centres in recent years. There has been no comparison of the efficacy between these two anterior reconstructing cages. The purpose of this study was to compare the radiographic and clinical outcomes of these two different devices.Methods
Sixty-seven eligible patients with single-level ACCF using TMC or n-HA/PA66 cage for cervical degenerative diseases, with four-year minimum follow-up, were included in this prospective non-randomised comparative study. Their radiographic (cage subsidence, fusion status, segmental sagittal alignment [SSA]) and clinical (VAS and JOA scales) data before surgery and at each follow-up was recorded completely.Results
The fusion rate of the n-HA/PA66 group was higher than TMC at one year after surgery (94 % vs. 84 %) though their finial fusion rates were similar (97 % vs. 94 %). Finial n-HA/PA66 cage subsidence was 1.5 mm with 6 % of severe subsidence over three millimetres, which was significantly lower than the respective 2.9 mm and 22 % of TMC (P < 0.0001). Lastly, SSA, VAS and JOA in TMC group were worse than in the n-HA/PA66 group (P = 0.235, 0.034 and 0.007, respectively).Conclusions
The n-HA/PA66 cage is associated with earlier radiographic fusion, less subsidence and better clinical results than TMC within four years after one-level ACCF. With the added benefit of radiolucency, the n-HA/PA66 cage may be superior to TMC in anterior cervical construction. 相似文献958.
Yuntong Zhang Yang Tang Chuncai Zhang Xue Zhao Yang Xie Shuogui Xu 《International orthopaedics》2013,37(6):1039-1044
Purpose
Dislocation following total hip arthroplasty (THA) with the posterior approach has been quite a common and bothering complication. Previous researches suggest that careful repair of the posterior structures significantly reduces this risk. The purposes of the present study were to describe a modified posterior soft tissue repair procedure in THA using a suture anchor (TwinFix Ti 5.0, Smith & Nephew, Andover, MA) and evaluate the early postoperative dislocation rate.Methods
From July 2004 to June 2008, 220 consecutive primary total hip arthroplasties were performed using the modified surgical approach. The average age in the group was 46.4 years (range from 21 to 90) at the time of the procedure. The rate of postoperative hip dislocation, as well as any signs of complications related to the technique, has been observed and analyzed in this study.Results
There was no postoperative dislocation following primary THA in 220 cases, and no signs of complications related to the technique, such as greater trochanteric fractures and sciatic nerve palsy, have been noted in any of the cases at their most recent follow-up.Conclusions
These initial results demonstrate that the modified repair in THA using the suture anchor can serve as an effective and reliable mean for prevention of early postoperative dislocation 相似文献959.
ChunHui Lan XiaoChun Shen HongLi Cui HaiYan Liu Ping Li Xue Wan Li Lan DongFeng Chen 《Journal of gastrointestinal surgery》2013,17(6):1066-1072
Background
In China, great efforts are dedicated to reducing discomfort and minimizing undesirable complications for patients undergoing upper gastrointestinal (UGI) endoscopy.Methods
This study was conducted to compare the diagnostic accuracy, safety, complications, and patient and examiner satisfaction for different sedation approaches. We carried out a prospective and randomized study on 450 patients undergoing diagnostic UGI endoscopy. During the procedure, patients received N2O by inhalation; an intravenous mixture of midazolam, remifentanil, and propofol; or no sedative. The cardiorespiratory functions, procedure duration, recovery time, length of hospital stay, complications, and ratings of patient and examiner satisfaction were recorded.Results
Compared to those deeply sedated, patients inhaling N2O had comparable diagnostic accuracy, significantly shorter procedure and recovery times, a lower risk of cardiorespiratory distress, but a higher number of minor complications and post-procedure mental issues. The procedural satisfaction ratings were highest for those receiving deep sedation; fewer patients reported willingness to reconsider N2O for a future upper GI endoscopy. The lowest satisfaction rating was given by those who received no sedation.Conclusions
Multiple factors should be considered before selecting N2O as the sedative for diagnostic UGI endoscopy, including the patient’s economic status, potential risk of cardiorespiratory distress, and sensitivity to potential adverse effects of N2O administration. 相似文献960.