全文获取类型
收费全文 | 2689篇 |
免费 | 116篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 40篇 |
妇产科学 | 56篇 |
基础医学 | 416篇 |
口腔科学 | 11篇 |
临床医学 | 328篇 |
内科学 | 490篇 |
皮肤病学 | 52篇 |
神经病学 | 334篇 |
特种医学 | 44篇 |
外科学 | 427篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 169篇 |
眼科学 | 82篇 |
药学 | 227篇 |
中国医学 | 9篇 |
肿瘤学 | 112篇 |
出版年
2023年 | 5篇 |
2022年 | 15篇 |
2021年 | 35篇 |
2020年 | 20篇 |
2019年 | 22篇 |
2018年 | 41篇 |
2017年 | 22篇 |
2016年 | 20篇 |
2015年 | 42篇 |
2014年 | 50篇 |
2013年 | 83篇 |
2012年 | 164篇 |
2011年 | 189篇 |
2010年 | 84篇 |
2009年 | 97篇 |
2008年 | 195篇 |
2007年 | 203篇 |
2006年 | 219篇 |
2005年 | 192篇 |
2004年 | 215篇 |
2003年 | 200篇 |
2002年 | 202篇 |
2001年 | 31篇 |
2000年 | 16篇 |
1999年 | 36篇 |
1998年 | 53篇 |
1997年 | 58篇 |
1996年 | 33篇 |
1995年 | 23篇 |
1994年 | 22篇 |
1993年 | 24篇 |
1992年 | 17篇 |
1991年 | 10篇 |
1990年 | 12篇 |
1989年 | 21篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 18篇 |
1985年 | 12篇 |
1984年 | 15篇 |
1983年 | 11篇 |
1982年 | 8篇 |
1981年 | 14篇 |
1980年 | 9篇 |
1979年 | 12篇 |
1978年 | 5篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1973年 | 3篇 |
1972年 | 3篇 |
排序方式: 共有2826条查询结果,搜索用时 15 毫秒
101.
102.
103.
Helen E.D. Burchett Sandra Mounier-Jack Sergio Torres-Rueda Ulla K. Griffiths Pierre Ongolo-Zogo Stephen Rulisa Jean-Marie Edengue Enrique Chavez Yayehirad Kitaw Mitike Molla Mamadou Konate Lawrence Gelmon Washington Onyango-Ouma Mylene Lagarde Anne Mills 《Vaccine》2014
Objective
We aimed to explore the impacts of new vaccine introductions on immunization programmes and health systems in low- and middle-income countries.Methods
We conducted case studies of seven vaccine introductions in six countries (Cameroon, PCV; Ethiopia, PCV; Guatemala, rotavirus; Kenya, PCV; Mali, Meningitis A; Mali, PCV; Rwanda, HPV). Interviews were conducted with 261 national, regional and district key informants and questionnaires were completed with staff from 196 health facilities. Routine data from districts and health facilities were gathered on vaccination and antenatal service use. Data collection and analysis were structured around the World Health Organisation health system building blocks.Findings
The new vaccines were viewed positively and seemed to integrate well into existing health systems. The introductions were found to have had no impact on many elements within the building blocks framework. Despite many key informants and facility respondents perceiving that the new vaccine introductions had increased coverage of other vaccines, the routine data showed no change. Positive effects perceived included enhanced credibility of the immunisation programme and strengthened health workers’ skills through training. Negative effects reported included an increase in workload and stock outs of the new vaccine, which created a perception in the community that all vaccines were out of stock in a facility. Most effects were found within the vaccination programmes; very few were reported on the broader health systems. Effects were primarily reported to be temporary, around the time of introduction only.Conclusion
Although the new vaccine introductions were viewed as intrinsically positive, on the whole there was no evidence that they had any major impact, positive or negative, on the broader health systems. 相似文献104.
105.
Magdalena Kraft Macarena Pia Knop Jean-Marie Renaudin Kathrin Scherer Hofmeier Claudia Pföhler Maria Beatrice Bilò Roland Lang Regina Treudler Nicola Wagner Thomas Spindler Jonathan O'B Hourihane Ioana Maris Alice Koehli Andrea Bauer Lars Lange Sabine Müller Nikolaos G. Papadopoulos Bettina Wedi Anne Moeser Luis F. Ensina Montserrat Fernandez-Rivas Ewa Cichocka-Jarosz George Christoff Blanca E. Garcia Iwona Poziomkowska-Gęsicka Victoria Cardona Tihomir B. Mustakov Uta Rabe Vera Mahler Linus Grabenhenrich Sabine Dölle-Bierke Margitta Worm The Network for Online Registration of Anaphylaxis 《Allergy》2020,75(4):901-910
106.
Antoine Néel Benoit Henry Sebastien Barbarot Agathe Masseau François Perrin Claire Bernier Xavier Kyndt Xavier Puechal Pierre-Jean Weiller Olivier Decaux Jacques Ninet Arnaud Hot Achille Aouba Leonardo Astudillo Jean-Marie Berthelot Fabrice Bonnet Jean-Marie Brisseau Bérangère Cador Fabienne Closs-Prophette Thomas Dejoie Jean-Dominique de Korwin Robin Dhote Renato Fior Bernard Grosbois Eric Hachulla Pierre-Yves Hatron Henry Jardel David Launay Adrien Lorleac'h Pierre Pottier Guillaume Moulis Jacques Serratrice Amar Smail Mohamed Hamidou 《Autoimmunity reviews》2014,13(10):1035-1041
The aim of this study is to assess the long-term effectiveness and safety of IL1Ra in Schnitzler syndrome (SchS). Between 2010 and 2012, we performed a nationwide survey among French internal medicine departments to identify SchS patients. We retrospectively analyzed the long-term efficacy and safety of IL1Ra and the outcome of patients that did not receive this treatment. Forty-two patients were included in the study, 29 of whom received IL1Ra. The mean age at disease onset was 59.9 years. Disease manifestations included urticaria (100%), fever (76%), bone/joint pain (86%), bone lesions (76%), anemia (67%), and weight loss (60%). The monoclonal gammopathy was overwhelmingly IgM kappa (83%). The mean follow-up was 9.5 years (range: 1.6-35). Two patients developed Waldenström's macroglobulinemia and one developed AA amyloidosis. All of the 29 patients who received IL1Ra responded dramatically. After a median follow-up of 36 months (range: 2-79), the effectiveness remained unchanged. All patients remained on anti-IL-1 therapy. Twenty-four patients (83%) went into complete remission and five (17%) into partial remission. Three patients experienced grade 3-4 neutropenia. Six patients developed severe infections. No lymphoproliferative diseases occurred while on IL1Ra. When last seen, all patients without anakinra had an active disease with variable impact on their quality of life. Their median corticosteroids dosage was 6 mg/d (range: 5-25). IL1Ra is effective in SchS, with a sharp corticosteroid-sparing effect. Treatment failures should lead to reconsider the diagnosis. Long-term follow-up revealed no loss of effectiveness and a favorable tolerance profile. The long-term effects on the risk of hemopathy remain unknown. 相似文献
107.
Rahul R. Singh Nurdan Ozyilmaz Simon Waller Jean-Marie U-King-Im Ming Lim Ata Siddiqui Manish D. Sinha 《European journal of pediatrics》2014,173(9):1225-1231
Posterior reversible encephalopathy syndrome (PRES) is characterized clinically by headaches, seizures, vomiting, nausea, visual abnormalities, and altered mental function and is often (but not invariably) accompanied by parieto-occipital imaging features. The aim of this study is to describe the clinical and radiological features and outcome following PRES in a paediatric cohort. From a retrospectively identified cohort, case records were studied to confirm a diagnosis of PRES. Neuroimaging was reviewed again to assign to recently described radiological subtypes parieto-occipital pattern, holohemispheric watershed pattern, dominant superior frontal sulcus pattern, and asymmetrical or partial expression of the three primary patterns (A/P). Patient outcome was measured by the modified Rankin scale (mRS) scores. Nine boys and three girls with mean age of 12 were identified. Hypertensive episodes (n?=?11), tacrolimus toxicity (n?=?4), and autoimmunity (n?=?1) were identified as potential risk factors/etiologies. Their median mRS at the peak of illness was 2 (range 2–5); three children required intensive care support. After mean follow-up of 35 months (median 37 months; range 3–60 months), all patients improved significantly with mean mRS of 1 (median 1; range 0–1). Conclusion: PRES is easily recognizable by the clinical and radiological features. Although severe at presentation, the outcome from this condition is favorable. 相似文献
108.
109.