全文获取类型
收费全文 | 4824篇 |
免费 | 229篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 164篇 |
妇产科学 | 64篇 |
基础医学 | 596篇 |
口腔科学 | 32篇 |
临床医学 | 421篇 |
内科学 | 1334篇 |
皮肤病学 | 58篇 |
神经病学 | 392篇 |
特种医学 | 95篇 |
外国民族医学 | 2篇 |
外科学 | 913篇 |
综合类 | 12篇 |
预防医学 | 177篇 |
眼科学 | 220篇 |
药学 | 270篇 |
中国医学 | 3篇 |
肿瘤学 | 335篇 |
出版年
2022年 | 39篇 |
2021年 | 74篇 |
2020年 | 35篇 |
2019年 | 58篇 |
2018年 | 100篇 |
2017年 | 55篇 |
2016年 | 51篇 |
2015年 | 55篇 |
2014年 | 92篇 |
2013年 | 171篇 |
2012年 | 257篇 |
2011年 | 267篇 |
2010年 | 172篇 |
2009年 | 170篇 |
2008年 | 287篇 |
2007年 | 366篇 |
2006年 | 315篇 |
2005年 | 301篇 |
2004年 | 282篇 |
2003年 | 253篇 |
2002年 | 255篇 |
2001年 | 118篇 |
2000年 | 128篇 |
1999年 | 109篇 |
1998年 | 74篇 |
1997年 | 61篇 |
1996年 | 44篇 |
1995年 | 35篇 |
1994年 | 40篇 |
1993年 | 26篇 |
1992年 | 68篇 |
1991年 | 56篇 |
1990年 | 62篇 |
1989年 | 64篇 |
1988年 | 38篇 |
1987年 | 53篇 |
1986年 | 49篇 |
1985年 | 41篇 |
1984年 | 31篇 |
1983年 | 28篇 |
1981年 | 21篇 |
1979年 | 25篇 |
1975年 | 27篇 |
1974年 | 23篇 |
1972年 | 16篇 |
1970年 | 21篇 |
1969年 | 17篇 |
1967年 | 16篇 |
1966年 | 18篇 |
1965年 | 21篇 |
排序方式: 共有5120条查询结果,搜索用时 15 毫秒
991.
Mathias Bruyand Marie-Anne Vandenhende Guillaume Marcel Estibaliz Lazaro Marie-Edith Lafon Michel Dupon François Dabis Stéphane Geffard Hervé Fleury Muriel Faure-Della Corte Fabrice Bonnet Rodolphe Thiebaut Isabelle Garrigue 《Journal of clinical virology》2011,50(2):177-180
BackgroundCMV reactivation, which enhances immune senescence, could be associated with a higher risk of cancer.ObjectivesWe compared the prevalence of positive CMV DNAemia in HIV-infected patients with and without cancer.Study designThis case–control study, nested in the ANRS-CO3 Aquitaine Cohort, included patients with a first diagnosis of cancer (2002–2007) as cases. Two controls were matched per case.Cancer risk was estimated using conditional logistic regression models, an Odds Ratio (OR) of 2 could be detected with 80% power. The variables considered were: ≥1 positive CMV DNAemia, CD4+ and CD8+ counts, HIV plasma load. Plasma CMV DNA was retrospectively quantified within the 3-year period preceding the endpoint.ResultsThe 143 cases (93 non-AIDS-related and 50 AIDS-related cancers) and 284 controls had a median age of 47 years (IQR: 41–56). At the time of diagnosis or censorship, for cases and controls, median values were respectively, for CD4+ count: 327 cells/mm3 (IQR: 164–514) and 416 (IQR: 275–582), and for HIV plasma load: 2.6 log10 copies/mL (IQR: 1.7–4.7) and 1.7 log10 copies/mL (IQR: 1.7–3.3). We performed 2056 CMV PCR; 14 cases (9.8% [95% CI: 4.9–14.7]) and 19 controls (6.7% [CI: 3.8–9.6]) presented ≥1 positive PCR. CMV DNAemia was not associated with the risk of cancer (unadjusted and adjusted p-values = 0.19 and 0.54, respectively). HIV load >500 copies/mL was independently associated with a higher risk of cancer (OR = 2.02; p = 0.002; 95% CI: 1.29–3.17).ConclusionThis large case–control study did not show any differential exposure to positive CMV plasma DNAemia between cancer cases and controls. 相似文献
992.
993.
Skilton MR Lange C Lantieri O Balkau B Bonnet F;DESIR study group 《Diabetes & metabolism》2011,37(4):351-355
Aim
Parity is associated with an increased risk of coronary heart disease and type 2 diabetes, possibly mediated by long-term modification of metabolic health. Studying associations between the number of children with health and disease in men in addition to women allows for differentiation between the social and lifestyle influences of child-rearing, and the biological influences of childbearing. We sought to determine whether the number of children is associated with the incidence of raised fasting glucose (fasting plasma glucose ≥ 6.1 mmol/L) and changes in glucose, insulin, insulin resistance and β-cell function over 9-years.Methods
Analysis of 1798 women and 1737 men from the DESIR study.Results
The number of children was associated with change in fasting glucose for women (Ptrend = 0.02) and men (Ptrend = 0.03), and increased incidence of raised fasting glucose by 30% (95% CI: 15, 47%) per child for men, but not women (3% [95% CI: −8, 15%]). There was a J-shaped association between number of children and change in insulin (P = 0.01) and insulin resistance (P = 0.005) for women, and a reduction in β-cell function in parous women (P = 0.07). Men with children had increases in insulin (P = 0.02), insulin resistance (P = 0.02), and β-cell function (P = 0.07).Conclusions
The number of children a person has is associated with changes in metabolic health indices long after childbirth for both men and women. The distinct gender differences in deterioration of metabolic health indices emphasize that childbearing and child-rearing are likely to have differential influences on metabolic health. 相似文献994.
Bariohay B Roux JA Bonnet MS Dallaporta M Troadec JD 《Recent Patents on CNS Drug Discovery》2011,6(3):164-180
Obesity is one of the most important and disturbing global epidemic that affects humans, with more than 2 billion people overweight and 700 million obese predicted for 2015 by the World Health Organization. Obesity treatment represents then one of the most exciting challenges for the academic researchers and the pharmaceutical industry. But to date, this community failed to develop safe and effective treatments with a good risk/benefit profile. Indeed, most of the drugs previously used as anti-obesity agents have been withdrawn from the market for safety issues, and therapeutic options in form of a medication are currently very limited. This last decade however, new advances in our understanding of central pathways controlling food intake, body weight and energy homeostasis have led to the discovery of new molecular targets that could provide interesting options in the fight against obesity. This review aims to be an overview of the new patents exploiting the anorexigenic properties of the central catabolic pathways or aimed at blocking the orexigenic effects of the anabolic pathways, in the hope to develop new anti-obesity drugs. 相似文献
995.
Biomechanical analysis of polypropylene prosthetic implants for hernia repair: an experimental study
Fabrice Sergent Nicolas Desilles Yann Lacoume Jean-Jacques Tuech Jean-Paul Marie Claude Bunel 《American journal of surgery》2010,200(3):406-412
Background
Although polypropylene (PP) is the most common biomaterial used for ventral and inguinal hernia repairs, its mechanical properties remain obscure.Methods
Retraction, solidity, and elasticity of 3 large pore-size monofilament PP prostheses, 1 heavy-weight PP (HWPP), a second low-weight PP, and a third coated with atelocollagen were evaluated in a rabbit incisional hernia model. A small pore-size multifilament PP implant (MPP) also was tested.Results
Unlike pore size, the weight of the prosthesis was not an influencing factor for retraction. Atelocollagen coating reduced retraction (P < .05). HWPP and MPP were less likely to rupture (P < .05). HWPP had comparatively better elasticity (P < .05), whereas MPP supported the greatest elastic force (P < .05). Nevertheless, the amount of shrinkage of MPP (30% of the original size) made this prosthesis unusable.Conclusions
In this study, HWPP presented the most advantageous biomechanical compromise for hernia surgery. 相似文献996.
997.
998.
999.