全文获取类型
收费全文 | 3557篇 |
免费 | 102篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 63篇 |
妇产科学 | 49篇 |
基础医学 | 536篇 |
口腔科学 | 30篇 |
临床医学 | 336篇 |
内科学 | 886篇 |
皮肤病学 | 100篇 |
神经病学 | 299篇 |
特种医学 | 146篇 |
外科学 | 381篇 |
综合类 | 15篇 |
预防医学 | 242篇 |
眼科学 | 56篇 |
药学 | 296篇 |
中国医学 | 10篇 |
肿瘤学 | 223篇 |
出版年
2023年 | 12篇 |
2022年 | 12篇 |
2021年 | 35篇 |
2020年 | 21篇 |
2019年 | 26篇 |
2018年 | 32篇 |
2017年 | 21篇 |
2016年 | 21篇 |
2015年 | 38篇 |
2014年 | 60篇 |
2013年 | 97篇 |
2012年 | 214篇 |
2011年 | 234篇 |
2010年 | 105篇 |
2009年 | 139篇 |
2008年 | 252篇 |
2007年 | 283篇 |
2006年 | 263篇 |
2005年 | 326篇 |
2004年 | 259篇 |
2003年 | 240篇 |
2002年 | 272篇 |
2001年 | 47篇 |
2000年 | 36篇 |
1999年 | 47篇 |
1998年 | 60篇 |
1997年 | 50篇 |
1996年 | 43篇 |
1995年 | 36篇 |
1994年 | 36篇 |
1993年 | 44篇 |
1992年 | 22篇 |
1991年 | 18篇 |
1990年 | 20篇 |
1989年 | 18篇 |
1988年 | 14篇 |
1987年 | 9篇 |
1986年 | 15篇 |
1985年 | 16篇 |
1984年 | 22篇 |
1983年 | 19篇 |
1982年 | 19篇 |
1981年 | 22篇 |
1980年 | 18篇 |
1979年 | 16篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1974年 | 6篇 |
排序方式: 共有3678条查询结果,搜索用时 15 毫秒
41.
42.
43.
Tardif JC Grégoire J Lespérance J Lambert J L'Allier PL Rodés J Anderson T Blue JW Imus J Heinonen T 《American heart journal》2002,144(4):589-596
Background Although statins have been shown to be beneficial in the management of hyperlipidemia and the reduction of cardiovascular morbidity and mortality, rates of major cardiovascular events remain high despite their use. Inhibition of the acyl coenzyme A: cholesterol acyltransferase (ACAT) enzyme in the arterial wall may prevent excess accumulation of cholesteryl esters in macrophages. In addition to ACAT inhibitor monotherapy, combination of a statin with an ACAT inhibitor may be a promising approach to further prevent the progression of atherosclerosis. Methods This report describes the design and methodologic features of a double-blind, randomized, placebo-controlled trial to assess the effect of the ACAT inhibitor avasimibe at 50-, 250-, and 750-mg daily dosages on the progression of coronary atherosclerosis as assessed by intravascular ultrasound (IVUS). All patients receive background lipid-lowering therapy when necessary. The study population consists of patients with at least one 20% to 50% diameter stenosis in a coronary artery with a reference diameter of ≥2.5 mm. IVUS and coronary angiography are performed at baseline and repeated at 24 months. The primary study end point is the change from baseline in plaque volume in a 30-mm segment of the coronary artery assessed by 3-dimensional IVUS. Several other IVUS and angiographic end points are measured. Conclusions The Avasimibe and Progression of coronary Lesions assessed by intravascular UltraSound (A-PLUS) trial is among the first large imaging trials to use IVUS as a primary end point and assesses the effects of the ACAT inhibitor avasimibe on atherosclerosis progression. (Am Heart J 2002;144:589-96.) 相似文献
44.
45.
Alain Putot Marianne Zeller Sophie Perrin Jean-Claude Beer Jack Ravisy Charles Guenancia Raphaël Robert Patrick Manckoundia Yves Cottin 《The American journal of medicine》2018,131(4):422-429.e4
Background
Red blood cell transfusion benefit during acute myocardial infarction remains unclear in the elderly. We aimed to assess the transfusion impact on 1-year mortality in acute myocardial infarction patients aged ≥65 years, according to their age and hemoglobin nadir.Methods
We included 3316 consecutive patients with acute myocardial infarction aged ≥65 years from the “obseRvatoire des Infarctus de Côte d'Or” (RICO) survey. They were categorized according to their hemoglobin nadir (≤8, >8 to ≤10, and >10 g/dL) and age (<80 or ≥80 years).Results
A total of 1906 patients (57%) were 65-79 years old, and 1410 (43%) were aged ≥80 years, of whom 103 (5%) and 145 (10%) patients received red blood cell transfusion, respectively (P < .001). In Cox regression analysis, transfusion was associated with increased 1-year mortality for hemoglobin nadir >10 g/dL but no significant effect for hemoglobin nadir between 8 and 10 g/dL. When hemoglobin nadir was ≤8 g/dL, transfusion did not influence 1-year mortality for younger patients (65-79 years). However, for older patients (≥80 years), transfusion was associated with lower mortality (hazard ratio 0.43 [95% confidence interval, 0.22-0.86], P = .016).Conclusion
Among older patients with acute myocardial infarction, the effect of transfusion was largely dependent on hemoglobin threshold and age. Transfusion was associated with increased 1-year mortality when hemoglobin nadir was >10 g/dL. However, in patients aged ≥80 years with hemoglobin nadir <8 g/dL, transfusion was associated with a 50% reduction in 1-year mortality. 相似文献46.
L'Huillier I Cottin Y Touzery C Zeller M Beel JC Fraison M Verges B Louis P Brunotte F Wolf JE 《International journal of cardiology》2003,90(2-3):165-173
Objective: This study was designed to assess the prognostic value of myocardial tomoscintigraphy perfusion imaging after percutaneous coronary intervention (PCI) in asymptomatic diabetic patients. Methods: One hundred and fourteen diabetic patients were followed up during 27±16 (mean±SD) months after the myocardial tomoscintigraphy. PCI-related events were studied after myocardial tomoscintigraphy stress testing and included major cardiac events (MACE) (cardiovascular death, myocardial infarction) and revascularization (bypass surgery or new PCI). Stress myocardial tomoscintigraphy imaging was performed 5±5 months after PCI and ischemia was considered as present if at least 2 contiguous segments were showing reversible defects. Results: Persistent silent ischemia was found in 49/114 (43%) patients. No difference was observed between the two groups for MACE: four among the 65 (6%) non ischemic patients versus 2 among the 49 (4%) ischemic patients (NS). In contrast, 15 (31%) among the ischemic patients and 4 (6%) among the non ischemic patients underwent iterative revascularization (p<0.01). The relative risk of revascularization for patients with significant ischemia was 5.5 versus non ischemic patients (p<0.001). Conclusion: After PCI, in asymptomatic diabetic patients followed by myocardial tomoscintigraphy a high frequency of persistent silent ischemia was found and associated with a high risk for repeat interventional procedure, although no increase in major cardiac events was observed. 相似文献
47.
We thank Drs Michalsen and Dobos for their comments. Restingheart rate is indeed a strong predictor of mortality in patientswith coronary artery disease.1 相似文献
48.
49.
50.