全文获取类型
收费全文 | 137篇 |
免费 | 13篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 8篇 |
基础医学 | 10篇 |
口腔科学 | 14篇 |
临床医学 | 21篇 |
内科学 | 14篇 |
皮肤病学 | 2篇 |
神经病学 | 1篇 |
特种医学 | 24篇 |
外科学 | 13篇 |
综合类 | 5篇 |
预防医学 | 4篇 |
眼科学 | 2篇 |
药学 | 8篇 |
中国医学 | 1篇 |
肿瘤学 | 25篇 |
出版年
2022年 | 1篇 |
2021年 | 5篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 14篇 |
2014年 | 2篇 |
2013年 | 7篇 |
2012年 | 11篇 |
2011年 | 6篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 5篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2004年 | 9篇 |
2003年 | 2篇 |
2002年 | 1篇 |
2001年 | 3篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有152条查询结果,搜索用时 234 毫秒
31.
32.
Diego Adrianzen Herrera Noah Kornblum Olga Derman Lizamarie Bachier-Rodriguez R. Alejandro Sica Aditi Shastri Murali Janakiram Amit Verma Ira Braunschweig Ioannis Mantzaris 《Clinical Lymphoma, Myeloma & Leukemia》2019,19(8):516-521
IntroductionIn the United States, autologous hematopoietic cell transplantation (autoHCT) has fallen out of favor over chemotherapy consolidation for non–high-risk acute myeloid leukemia (AML) when allogeneic hematopoietic cell transplantation (alloHCT) is unfeasible, which is common in racial minorities because of donor registry under-representation and socioeconomic challenges. We compared autoHCT consolidation outcomes with chemotherapy alone in a minority-rich cohort in the Bronx.Patients and MethodsWe identified adults with favorable or intermediate cytogenetic risk AML in first complete remission after induction at Montefiore Medical Center from 1999 to 2015, and analyzed 81 patients who received consolidation with ≥2 cycles of chemotherapy, of whom 28 received autoHCT.ResultsThe cohort predominantly consisted of ethnic/racial minorities (69%). Age, sex, race, presenting white cell count, and cytogenetic risk were similar between groups. The autoHCT group had longer relapse-free (RFS; 43 vs. 11 months; P = .003) and overall (OS) survival (not reached vs. 36 months; P = .043). Adjusted multivariable analysis showed significant benefit of autoHCT over chemotherapy alone for RFS (hazard ratio [HR], 0.53; 95% confidence interval [CI], 0.37-0.75; P < .001) and OS (HR, 0.61; 95% CI, 0.40-0.95; P = .027).ConclusionIn this inner-city non–high-risk AML cohort, autoHCT provided OS and RFS benefit compared with chemotherapy alone. AutoHCT might constitute a valuable option for ethnic/racial minorities affected by significant barriers to alloHCT, whereas integration of measurable residual disease can help select patients more likely to benefit. 相似文献
33.
Naveena B Janakiram Altaf Mohammed Li Qian Chang-In Choi Vernon E Steele Chinthalapally V Rao 《Neoplasia (New York, N.Y.)》2012,14(2):159-168
Retinoid X receptor (RXR) has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics). Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. Before the efficacy studies, we determined that the maximal tolerated dose in C57BL/6J mice was less than 400 ppm. For the efficacy study, 6-week-old male and female C57BL/6J-ApcMin/+ mice (nine mice per group) were fed diets containing 0, 30, and 60 ppm of bexarotene or 200 ppm of bexarotene for 80 days before intestinal tumors were evaluated. Dietary administration of 30 and 60 ppm of bexarotene suppressed the intestinal polyp formation by 38% (P < .015) and 60% (P < .0001) in males, respectively, and by 8.5% and 37% (P < .007) in females, respectively. Also, significant inhibition (50%–100%) of colonic tumor formation was observed in both male and female mice with bexarotene treatment. Administration of 200 ppm of bexarotene showed significant suppression of tumor formation (66%, P < .0001); however, it had significant toxicity. Intestinal tumors of bexarotene-fed mice showed significantly reduced expression of proliferating cell nuclear antigen (60%, P < .0001), cyclin D1, and cyclooxygenase 2 and increased RXR-α messenger RNA and uptake of oleate (34%, P < .01). Also, bexarotene-fed mice showed dose-dependent suppression of serum triglycerides (25%–72%, P < .0001) and inflammatory cytokines. 相似文献
34.
35.
Any waste generated consequent to health care activity including any from a home environment is health care waste. Dental practices generate large amounts of waste cotton, plastic, latex, glass and other materials much of which may be contaminated with body fluids. OBJECTIVE: To assess the knowledge, attitude and behaviour of private dental practitioners on health care waste management in Bangalore City. METHODS: A cross-sectional study of 432 private dental practitioners in Bangalore City using a self-administered questionnaire. RESULTS: 389 dentists responded; 64.3% do not segregate waste before disposal and 47.6% hand over health care waste to street garbage collectors; 42.1% felt that there was a lack of waste management agency services and 16.9% felt that a lack of knowledge were the main hurdles. CONCLUSIONS: Dentists need education regarding health care waste disposal methods to improve their knowledge. A large proportion of the dentists are not practising proper methods of health care waste disposal. The existence of legislation governing healthcare waste disposal is not sufficient alone to motivate many practitioners to comply with guidelines. 相似文献
36.
37.
38.
Urvi A. Shah MD Nishi Shah MD MPH Baozhen Qiao PhD Ana Acuna-Villaorduna MD Kith Pradhan PhD Diego Adrianzen Herrera MD R. Alejandro Sica MD Aditi Shastri MD Ioannis Mantzaris MD Olga Derman MD Noah Kornblum MD Ira Braunschweig MD B. Hilda Ye PhD Amit Verma MD Murali Janakiram MD MS 《Cancer》2020,126(3):567-574
39.
40.
Trichy Narayanan Janakiram Vijayalakshmi Subramaniam Palak Parekh 《Indian journal of otolaryngology and head and neck surgery》2015,67(4):412-416
Endoscopic endonasal approaches are becoming increasingly popular over transcranial approaches for repair of cerebrospinal leak defects. Sphenoid sinus CSF leaks pose a significant challenge and carry the risk of life-threatening intracranial complications. Their management depends upon identifying the leak using imaging techniques followed by intraoperative endoscopic localization. Our experience in the endoscopic endonasal management of sphenoid sinus CSF leaks is reported in this paper. 相似文献