über Krebsantikörper bei Krebskranken

Zusammenfassung Es gelingt bei Krebskranken, vor allem aber bei solchen, die an Krebs des Verdauungstractus, Uterus und Mamma leiden, komplementbindende Antikörper nachzuweisen, die mit genügend empfindlichen Krebsantigenen reagieren.Ein geringer Teil dieser Sera gibt eine positive WaR.; positive Luessera reagieren mit alkoholischen Extrakten aus Krebs. Zur Erklärung wird der Begriff der Zerfallskrankheiten aufgestellt und die Mitreaktion auf das gleichzeitige Vorkommen der specifischen und unspecifischen Lipoide im Krebsgewebe zurückgeführt.Sera der Schwangeren reagieren ebenfalls mit Krebsantigenen. Es wird die Auffassung diskutiert, da\ es sich um Antikörper gegen Substanzen handelt, die während des Embryonalwachstums auftreten, und da\ diese Substanzen bei Krebs und Embryonen identisch oder verwandt sind. In diesem Falle wäre die Reaktion mit Krebsantigenen als eineWachstumsreaktion aufzufassen sein.Ausgeführt mit Unterstützung der Polnischen Akademie der Wissenschaften. Mitgeteilt am 7. Dezember 1929 in der Klinischen Sektion der Gesellschaft für soziale Medizin in Warschau.     

Über die Klinische Wertung der Komple-Mentbindungsreaktion mit Alkoholischen Krebsextrakten

Ohne ZusammenfassungAusgeführt mit Unterstützung der Polnischen Akademie der Wissenschaften Tyszkowski-Stiftung, gewährt L.Hirszfeld für Krebsforschungen. Eingereicht der Akademie am 6. II. 1931.     

Ventricular remodeling of the native heart after heterotopic heart transplantation.

Although ventricular remodeling after long-term unloading of the heart has been reported in patients after the use of medical therapy or left ventricular assist devices, it has rarely been reported in patients after heterotopic heart transplantation. Here, we describe a case of ventricular remodeling of the native heart after heterotopic heart transplantation. A 61-year-old man with end-stage dilated cardiomyopathy underwent heterotopic heart transplantation because of high pulmonary vascular resistance and a small donor heart. After the operation, echocardiography showed ventricular remodeling of the native heart, with decreased size and improved contractility of the left ventricle. Six months after the transplantation, acute graft failure of the donor heart occurred. However, the patient remained in good condition with the support of the improved native heart.     

Incidence Rate of Bee Venom Acupuncture Related Anaphylaxis: A Systematic Review

Background: Bee venom acupuncture (BVA) is an effective treatment method for various diseases. Bee venom, however, can cause adverse effects, even rarely including life-threatening anaphylaxis, so safety-related evidence is required. In this study, we systematically estimated the incidence rate of anaphylaxis in response to BVA. Methods: We searched eight databases (MEDLINE (Pubmed), EMBASE, Cochrane Central Register of Controlled, KISS, KMBASE, Koreamed, OASIS, and NDSL) and systematically reviewed the articles that met the inclusion/exclusion criteria. Results: Among 225 potentially relevant articles, 49 were selected for this study. The overall incidence rate of anaphylaxis in response to BVA was 0.045% (95% CI 0.028–0.062). Women (0.083%, 95% CI 0.010–0.157) showed a higher incidence rate than men (0.019%, 95% CI −0.018 to 0.055), while the incidence for patients who had a skin test conducted (0.041%, 95% CI 0.011–0.072) was not significantly different compared to that obtained for patients for which there was no information about a skin test (0.047%, 95% CI 0.026–0.067). The publication year affected the incidence rate: it was highest before 1999 (1.099%, 95% CI −1.043 to 3.241), lower between 2000 and 2009 (0.049%, 95% CI 0.025–0.073), and lowest between 2010 and 2021 (0.037% 95% CI 0.014–0.060). Conclusions: In this study, we provide reference data about risk size and factors of BVA-related anaphylaxis, which is essentially required for BVA application in clinics.     

Prospective Population-Based Study of Intermittent and Continuous Convulsive Status Epilepticus in Richmond, Virginia

PURPOSE: Previous work suggested that there is a lower mortality for convulsive status epilepticus (SE) with intermittent seizures (intermittent SE) as opposed to SE with continuous seizure activity (continuous SE). A plausible hypothesis to explain this difference is that the shorter ictal time in intermittent SE is responsible for the lower mortality in this group. This study investigates the relative contributions of total ictal time and SE duration to the differing mortalities of intermittent and continuous SE. METHODS: Six hundred forty-five cases of prospectively identified convulsive SE were examined. Nonparametric statistical methods were used to compare continuous SE and intermittent SE variables. Multivariate logistic regression analyses were used to determine which factors were most highly associated with mortality. Intermittent SE cases were analyzed to evaluate the relative contributions of ictal time versus SE duration to mortality. RESULTS: Intermittent SE had a significantly lower mortality than continuous SE (19.6 vs. 31.4%; p < 0.001) in adults but not in children. Intermittent and continuous SE durations did not significantly differ in adult cases but did differ in pediatric cases. Ictal time was significantly shorter than SE duration for intermittent SE in both adults and children. After adjusting for age, etiology, and SE duration, SE type (continuous SE vs. intermittent SE) was shown to have an independent effect on mortality in adults. The relative risk of mortality for continuous SE was 1.79 times that of intermittent SE (p = 0.04). After controlling for SE duration, ictal time did not significantly affect mortality in adults. CONCLUSIONS: Intermittent and continuous convulsive SE were common in both pediatric and adult populations. Intermittent SE had a significantly lower mortality than did continuous SE. This difference in mortality was not completely explained by differences in SE duration, total ictal time, etiology, or age. Further research is needed to identify the factor(s) contributing to the significant difference in mortality between intermittent SE and continuous SE.     

Correlating ultrasound findings of carpal tunnel syndrome with nerve conduction studies

Introduction: The aim of this study was to make correlations between ultrasonographic measurements of thenar muscle and flexor retinaculum and nerve conduction studies (NCS) in carpal tunnel syndrome (CTS). Methods: Ultrasound and NCS were performed on 92 wrists with CTS and on 40 wrists from healthy individuals. Ultrasound of thenar and hypothenar muscles, flexor retinaculum, and median nerve were assessed. The ultrasonographic findings were compared between the 2 groups, and correlation analyses between median latency and ultrasonographic findings were performed. Results: Motor latency correlated positively with flexor retinaculum thickness (FRT) and negatively with the ratio of thenar to hypothenar muscle. FRT and motor latency were found to be increased significantly in CTS. The ratio of thenar to hypothenar muscle was found to be decreased significantly in CTS compared with controls. Conclusions: The ultrasonographic findings of FRT and thenar muscle reflect the severity of disease in patients with CTS and are valuable for the diagnosis of CTS. Muscle Nerve 48 : 905–910, 2013