TISSUE ADHESIVE THERAPY FOR CORNEAL PERFORATIONS

The current indications for and method of application of tissue adhesive are described. A method for an expanded utilisation of tissue adhesive is discussed. To study the effect of the introduction of tissue adhesive to The Wilmer Institute in 1974, the records of 104 consecutive non-traumatic corneal perforations or descemetoceles admitted to The Wilmer Institute from 1960 to 1980 were assessed retrospectively with follow-up being obtained from records or from referral physicians for 87 of these perforations. Forty-nine percent of the cases were caused by bacterial corneal ulcers, 13% by exposure, 12% by chemical burns, 6% by fungal keratitis, 5% by herpes simplex keratitis, and 15% were undiagnosed. Since the introduction of tissue adhesive in 1974, there has been an apparent trend towards a lower enucleation rate (6%) in the tissue adhesive treated group compared with 19% in perforations treated by other therapies.     

高同型半胱氨酸血症促进动脉粥样硬化发生发展的炎症免疫机制

<正>心血管疾病是威胁人类健康的主要疾病。在中国,随着经济和社会的发展,心血管疾病的发病率已经排在各种疾病之首。有研究者预测,到2020年,全球范围内由于心血管疾病造成的死     

Relevance of immunophenotypes to prognostic subgroups of age,WBC, platelet count,and cytogenetics in de novo acute myeloid leukemia

Li X, Li J, Du W, Zhang J, Liu W, Chen X, Li H, Huang S, Li X. Relevance of immunophenotypes to prognostic subgroups of age, WBC, platelet count, and cytogenetics in de novo acute myeloid leukemia. APMIS 2010. Immunophenotyping is one of the independent prognostic factors in acute myeloid leukemia (AML). Relevance of immunophenotypes to prognostic subgroups of age, white blood cells (WBC), platelet count, and cytogenetics in de novo AML was comprehensively investigated in this study for the first time. Human leukocyte antigen (HLA)‐DR and CD14 expression associated with the elderly, highest WBC count, and unfavorable‐risk cytogenetics; CD4, CD7, and CD11b expression correlated with highest WBC count and unfavorable‐risk cytogenetics; CD64 expression was associated with higher WBC count while that of CD13 was associated with lower platelet count; CD22, CD34, CD123, and terminal deoxynucleotidyl transferase (TdT) expression correlated with unfavorable‐risk cytogenetics; CD5 expression was associated with normal platelet count while that of CD19 was associated with children and favorable‐risk cytogenetics; CD117 expression was associated with low WBC and lower platelet counts; myeloperoxidase (MPO) expression correlated with lower platelet count; and MPO and glycophorin A (Gly‐A) expression was associated with lower WBC count and favorable‐risk cytogenetics. The results of the relevance analysis revealed the distribution characteristics of antigen expression in different AML prognostic subgroups. The majority of antigens associated with good or poor prognostic subgroups were in accordance with the previous reports of correlation of expression of these antigens with prognosis. Antigens associated with good (or poor) prognostic subgroups were defined as good (or poor)‐risk antigens.     

High sensitivity cardiac troponin T and interleukin‐6 predict adverse cardiovascular events and mortality in anticoagulated patients with atrial fibrillation: a reply to a rebuttal

See also Roldán V, Marfn F, Díaz J, Gallego P, Jover E, Romera M, Manzano‐Fernández S, Casas T, Valdés M, Vicente V, Lip GYH. High sensitivity cardiac troponin T and interleukin‐6 predict adverse cardiovascular events and mortality in anticoagulated patients with atrial fibrillation. J Thromb Haemost 2012; 10: 1500–7; Providência R. High sensitivity cardiac troponin T and interleukin‐6 predict adverse cardiovascular events and mortality in anticoagulated patients with atrial fibrillation: a rebuttal. This issue, pp 2413.