全文获取类型
收费全文 | 4207篇 |
免费 | 289篇 |
国内免费 | 79篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 236篇 |
妇产科学 | 87篇 |
基础医学 | 519篇 |
口腔科学 | 83篇 |
临床医学 | 482篇 |
内科学 | 965篇 |
皮肤病学 | 90篇 |
神经病学 | 211篇 |
特种医学 | 574篇 |
外国民族医学 | 26篇 |
外科学 | 396篇 |
综合类 | 72篇 |
一般理论 | 1篇 |
预防医学 | 224篇 |
眼科学 | 64篇 |
药学 | 220篇 |
2篇 | |
中国医学 | 1篇 |
肿瘤学 | 285篇 |
出版年
2022年 | 26篇 |
2021年 | 49篇 |
2020年 | 36篇 |
2019年 | 64篇 |
2018年 | 97篇 |
2017年 | 69篇 |
2016年 | 67篇 |
2015年 | 84篇 |
2014年 | 119篇 |
2013年 | 152篇 |
2012年 | 163篇 |
2011年 | 159篇 |
2010年 | 173篇 |
2009年 | 155篇 |
2008年 | 158篇 |
2007年 | 197篇 |
2006年 | 147篇 |
2005年 | 147篇 |
2004年 | 127篇 |
2003年 | 101篇 |
2002年 | 102篇 |
2001年 | 106篇 |
2000年 | 102篇 |
1999年 | 92篇 |
1998年 | 150篇 |
1997年 | 172篇 |
1996年 | 148篇 |
1995年 | 127篇 |
1994年 | 129篇 |
1993年 | 117篇 |
1992年 | 80篇 |
1991年 | 75篇 |
1990年 | 68篇 |
1989年 | 100篇 |
1988年 | 66篇 |
1987年 | 82篇 |
1986年 | 93篇 |
1985年 | 68篇 |
1984年 | 45篇 |
1983年 | 30篇 |
1982年 | 32篇 |
1981年 | 38篇 |
1980年 | 31篇 |
1979年 | 18篇 |
1978年 | 14篇 |
1977年 | 23篇 |
1976年 | 29篇 |
1975年 | 26篇 |
1974年 | 18篇 |
1972年 | 14篇 |
排序方式: 共有4575条查询结果,搜索用时 10 毫秒
131.
Molecular heterogeneity in acute leukemia lineage switch 总被引:1,自引:0,他引:1
Gagnon GA; Childs CC; LeMaistre A; Keating M; Cork A; Trujillo JM; Nellis K; Freireich E; Stass SA 《Blood》1989,74(6):2088-2095
Six cases of acute leukemia that underwent lineage switch from acute lymphocytic leukemia to acute myelogenous leukemia are reported. The mean age of the patients was 24 years, time to conversion was 36 months, and survival after conversion was only 3 months. Of the three cases which showed abnormal metaphases at both diagnosis and conversion, two (cases 2, 5) showed related cytogenetic abnormalities, and the third showed (case 3) independent chromosomal changes. Molecular analysis for immunoglobulin heavy chain and T-cell receptor beta chain genes showed that five of the six cases had rearrangement of at least one of these lymphoid associated genes at conversion to acute myelogenous leukemia. The single case (case 3) in which there were no lymphoid gene rearrangements at conversion was also the only case in which independent karyotypic abnormalities at diagnosis and conversion were demonstrated. Our findings suggest that lineage switch can represent either relapse of the original clone with heterogeneity at the molecular level or the emergence of a second new leukemic clone without molecular heterogeneity. 相似文献
132.
Alexandre Rousseau Julie Fradette Geneviève Bernard Robert Gauvin Véronique Laterreur Stéphane Bolduc 《Journal of tissue engineering and regenerative medicine》2015,9(11):E135-E143
Despite a wide panel of tissue‐engineering models available for vesical reconstruction, the lack of a differentiated urothelium remains their main common limitation. For the first time to our knowledge, an entirely human vesical equivalent, free of exogenous matrix, has been reconstructed using the self‐assembly method. Moreover, we tested the contribution of adipose‐derived stromal cells, an easily available source of mesenchymal cells featuring many potential advantages, by reconstructing three types of equivalent, named fibroblast vesical equivalent, adipose‐derived stromal cell vesical equivalent and hybrid vesical equivalent – the latter containing both adipose‐derived stromal cells and fibroblasts. The new substitutes have been compared and characterized for matrix composition and organization, functionality and mechanical behaviour. Although all three vesical equivalents displayed adequate collagen type I and III expression, only two of them, fibroblast vesical equivalent and hybrid vesical equivalent, sustained the development of a differentiated and functional urothelium. The presence of uroplakins Ib, II and III and the tight junction marker ZO‐1 was detected and correlated with impermeability. The mechanical resistance of these tissues was sufficient for use by surgeons. We present here in vitro tissue‐engineered vesical equivalents, built without the use of any exogenous matrix, able to sustain mechanical stress and to support the formation of a functional urothelium, i.e. able to display a barrier function similar to that of native tissue. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
133.
Paul Rousseau MD 《Journal of the American Geriatrics Society》2015,63(8):1695-1696
134.
135.
136.
137.
138.
Octavio Cosin Hervé Rousseau Phillipe Otal Christoff Cron Valérie Chabbert Francis Joffre 《Journal of endovascular therapy》2006,13(5):676-680
PURPOSE: To describe a case involving perforation of a previously placed aortic Dacron graft by the uncovered proximal stent of a thoracic stent-graft. CASE REPORT: A 76-year-old man with a surgically treated type A dissection presented with residual type B dissection. Thoracic stent-grafting of the entry site was performed successfully. After 2 years, the patient was admitted for evaluation of a non-pulsating parasternal mass. Computed tomography showed a large, hypodense liquid-like mass affecting the mediastinum up to the subcutaneous tissue. A false aneurysm at the proximal end of the stent-graft was observed arising from an aortic perforation by the uncovered stent. One week later, the mass had almost completely resolved, and the patient has been scheduled for close surveillance. CONCLUSION: This case illustrated the importance of thoroughly examining the long-term durability and compatibility of prosthetic materials. 相似文献
139.
Rousseau K Atcha Z Denton J Cagampang FR Ennos AR Freemont AJ Loudon AS 《The Journal of endocrinology》2005,186(3):475-479
Recent studies have suggested that the adipocyte-derived hormone, leptin, plays a role in the regulation of metabolism. Here, we tested this hypothesis in the seasonally breeding Siberian hamster, as this species exhibits profound seasonal changes in adiposity and circulating leptin concentrations driven by the annual photoperiodic cycle. Male hamsters were kept in either long (LD) or short (SD) photoperiods. Following exposure to short photoperiods for 8 weeks animals exhibited a significant weight-loss and a 16-fold reduction of serum leptin concentrations. At Week 9, animals in both photoperiods were infused with leptin or PBS via osmotic mini-pump for 14 days. Chronic leptin infusion mimicked LD-like concentrations in SD-housed animals and caused a further decline in body weight and adipose tissue. In LD-housed animals, leptin infusion resulted in a significant elevation of serum concentrations above natural LD-like levels, but had no discernable effect on body weight or overall adiposity. Both bending and compression characteristics and histomorphometric measurements of trabecular bone mass were unaltered by leptin treatment or photoperiod. Our data therefore show that despite a high natural amplitude cycle of leptin, this hormone has no apparent role in the regulation of bone metabolism, and therefore do not support recent propositions that this hormone is an important component in the metabolism of bone tissue. 相似文献
140.
Hmem M Elbaz M Filali T Rousseau H Hoang V Maupas E Puel J Carrié D 《Archives des maladies du coeur et des vaisseaux》2005,98(10):1022-1025
Latrogenic fistula between the aorta and coronary vein is a rare complication of coronary bypass surgery due to accidental venous or arterial graft onto a coronary vein. The authors report a case of a patient admitted to hospital 2 months after coronary bypass surgery for cardiac failure due to a iatrogenic fistula by implantation of the left internal mammary artery on the great coronary vein. This presentation led to the choice of percutaneous embolisation of the fistula by the release of 6 coils. Based on a review of the literature, this clinical case illustrates the feasibility and value of percutaneous embolisation of iatrogenic fistulae. 相似文献