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991.
F Maloisel P Dufour J P Bergerat J P Bellocq B Duclos A Boilletot R Herbrecht P Dellenbach R Renaud P Ritter 《Bulletin du cancer》1989,76(10):1083-1093
One hundred and six patients with stage Ic to IV ovarian carcinoma were treated by a protocol consisting of optimal debulking surgery followed by 9 cycles of CHAP chemotherapy. Clinical response was confirmed by a second-look procedure. Sixty-nine patients (65%) responded with 54 histological complete remissions (50.8%). Nineteen patients did not receive any complementary treatment due to a negative reaction, or prolonged neutropenia. Seven patients received maintenance chemotherapy, 10 an abdominal radiotherapy, 22 intraperitoneal chemotherapy and 11 autologous bone marrow transplantation. The 5-year survival rate was 32.5% and disease-free survival rate was 39.7%. Prognostic-factor analysis showed that age, initial staging, residual disease and cytological grading were significant. The authors propose a classification based on the risk of relapse, and different therapeutic indications for improving response rate and patient survival. 相似文献
992.
M A Ritter 《Clinical orthopaedics and related research》1984,(190):11-13
People are the major source of bacterial contamination in the hospital environment, and to control environmental bacteria, the shedding potential of people must be controlled. In a conventional operating room, the more complete the surgical attire worn by everyone in the room, the better the control; i.e., body exhaust equipment for the anesthesiologist and the scrub nurse is essential. The laminar airflow filter system and ultraviolet light are effective environmental controls for preventing wound contamination. 相似文献
993.
994.
995.
Intraoperative ultrasound examination of the brain 总被引:5,自引:0,他引:5
In a preliminary demonstration of cranial intraoperative real-time ultrasound, both supratentorial and posterior fossa scans displayed the pertinent anatomy. A grade III astrocytoma was visualized on the supratentorial scan as well. Ultrasound may be valuable for surgical planning and biopsy procedures because of its reliable depiction of intracranial anatomy and ease of use. 相似文献
996.
The hemodynamic response to traction on the abdominal mesentery 总被引:2,自引:0,他引:2
997.
R?FoyEmail author MP?Eccles G?Jamtvedt J?Young JM?Grimshaw R?Baker 《BMC health services research》2005,5(1):50
Background
Improving the quality of health care requires a range of evidence-based activities. Audit and feedback is commonly used as a quality improvement tool in the UK National Health Service [NHS]. We set out to assess whether current guidance and systematic review evidence can sufficiently inform practical decisions about how to use audit and feedback to improve quality of care. 相似文献998.
Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement
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Thiele H Sakano M Kitagawa H Sugahara K Rajab A Höhne W Ritter H Leschik G Nürnberg P Mundlos S 《Proceedings of the National Academy of Sciences of the United States of America》2004,101(27):10155-10160
We studied two large consanguineous families from Oman with a distinct form of spondyloepiphyseal dysplasia (SED Omani type). By using a genome-wide linkage approach, we were able to map the underlying gene to a 4.5-centimorgan interval on chromosome 10q23. We sequenced candidate genes from the region and identified a missense mutation in the chondroitin 6-O-sulfotransferase (C6ST-1) gene (CHST3) changing an arginine into a glutamine (R304Q) in the well conserved 3'-phosphoadenosine 5'-phosphosulfate binding site. C6ST-1 catalyzes the modifying step of chondroitin sulfate (CS) synthesis by transferring sulfate to the C-6 position of the N-acetylgalactosamine of chondroitin. From the crystal structures of other sulfotransferases, it could be inferred that Arg-304 is essential for the structure of the cosubstrate binding site. We used recombinant C6ST-1 to show that the identified missense mutation completely abolishes C6ST-1 activity. Disaccharide composition analysis of CS chains by anion-exchange HPLC shows that both Delta HexA-GalNAc(6S) and Delta HexA(2S)-GalNAc(6S) were significantly reduced in the patient's cells and that Delta HexA-GalNAc(4S,6S), undetectable in controls, was elevated. Analysis of the patient's urine shows marked undersulfation of CS, in particular reduction in 6-O-sulfated disaccharide and an increase in the nonsulfated unit. Our results indicate that the mutation in CHST3 described here causes a specific but generalized defect of CS chain sulfation resulting in chondrodysplasia with major involvement of the spine. 相似文献
999.
Postow MA Callahan MK Barker CA Yamada Y Yuan J Kitano S Mu Z Rasalan T Adamow M Ritter E Sedrak C Jungbluth AA Chua R Yang AS Roman RA Rosner S Benson B Allison JP Lesokhin AM Gnjatic S Wolchok JD 《The New England journal of medicine》2012,366(10):925-931
The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.). 相似文献
1000.
Cyr AE Novack D Trinkaus K Margenthaler JA Gillanders WE Eberlein TJ Ritter J Aft RL 《Annals of surgical oncology》2011,18(4):946-951