全文获取类型
| 收费全文 | 4844494篇 |
| 免费 | 392673篇 |
| 国内免费 | 15769篇 |
专业分类
| 耳鼻咽喉 | 69317篇 |
| 儿科学 | 152994篇 |
| 妇产科学 | 129398篇 |
| 基础医学 | 729726篇 |
| 口腔科学 | 137300篇 |
| 临床医学 | 446804篇 |
| 内科学 | 881284篇 |
| 皮肤病学 | 114202篇 |
| 神经病学 | 409180篇 |
| 特种医学 | 191569篇 |
| 外国民族医学 | 1127篇 |
| 外科学 | 728981篇 |
| 综合类 | 139960篇 |
| 现状与发展 | 24篇 |
| 一般理论 | 2860篇 |
| 预防医学 | 412266篇 |
| 眼科学 | 115378篇 |
| 药学 | 344119篇 |
| 25篇 | |
| 中国医学 | 12394篇 |
| 肿瘤学 | 234028篇 |
出版年
| 2021年 | 56188篇 |
| 2019年 | 58916篇 |
| 2018年 | 74921篇 |
| 2017年 | 57019篇 |
| 2016年 | 63371篇 |
| 2015年 | 76125篇 |
| 2014年 | 110975篇 |
| 2013年 | 176403篇 |
| 2012年 | 135313篇 |
| 2011年 | 142153篇 |
| 2010年 | 128451篇 |
| 2009年 | 129496篇 |
| 2008年 | 128838篇 |
| 2007年 | 138230篇 |
| 2006年 | 145720篇 |
| 2005年 | 141050篇 |
| 2004年 | 141308篇 |
| 2003年 | 131459篇 |
| 2002年 | 121822篇 |
| 2001年 | 180986篇 |
| 2000年 | 178028篇 |
| 1999年 | 161795篇 |
| 1998年 | 74385篇 |
| 1997年 | 69867篇 |
| 1996年 | 67998篇 |
| 1995年 | 63648篇 |
| 1994年 | 57857篇 |
| 1993年 | 53628篇 |
| 1992年 | 121836篇 |
| 1991年 | 117474篇 |
| 1990年 | 112430篇 |
| 1989年 | 109306篇 |
| 1988年 | 101761篇 |
| 1987年 | 99903篇 |
| 1986年 | 95050篇 |
| 1985年 | 92521篇 |
| 1984年 | 76336篇 |
| 1983年 | 67786篇 |
| 1982年 | 51715篇 |
| 1981年 | 48009篇 |
| 1980年 | 45132篇 |
| 1979年 | 68845篇 |
| 1978年 | 54433篇 |
| 1977年 | 47539篇 |
| 1976年 | 44322篇 |
| 1975年 | 44654篇 |
| 1974年 | 51148篇 |
| 1973年 | 49323篇 |
| 1972年 | 46531篇 |
| 1971年 | 42948篇 |
排序方式： 共有10000条查询结果，搜索用时 929 毫秒
171.
172.
173.
174.
175.
Whitney S. Brandt Wanpu Yan Jian Zhou Kay See Tan Joseph Montecalvo Bernard J. Park Prasad S. Adusumilli James Huang Matthew J. Bott Valerie W. Rusch Daniela Molena William D. Travis Mark G. Kris Jamie E. Chaft David R. Jones 《The Journal of thoracic and cardiovascular surgery》2019,157(2):743-753.e3
Objective
Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non–small cell lung cancer has not been extensively studied.Methods
Patients with cT2-4N0-1M0 non–small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan–Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching.Results
In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response.Conclusions
Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non–small cell lung cancer who undergo complete surgical resection. 相似文献176.
177.
178.
179.
Metabolism describes the series of chemical reactions that are concerned with the provision of energy to biological systems. They may be divided into reactions involved in energy yield (catabolism: demand exceeds supply), and energy storage (anabolism: supply exceeds demand). Regulation of these pathways is critical for homeostasis, and derangements in metabolism are seen in a wide variety of pathological processes. Understanding metabolism is key to the treatment of many diseases, notably diabetes, as well as underpinning clinical nutritional support. 相似文献
180.