全文获取类型
收费全文 | 2865761篇 |
免费 | 223522篇 |
国内免费 | 5239篇 |
专业分类
耳鼻咽喉 | 41062篇 |
儿科学 | 89640篇 |
妇产科学 | 74981篇 |
基础医学 | 413250篇 |
口腔科学 | 81982篇 |
临床医学 | 261605篇 |
内科学 | 554815篇 |
皮肤病学 | 59418篇 |
神经病学 | 232980篇 |
特种医学 | 113021篇 |
外国民族医学 | 946篇 |
外科学 | 431971篇 |
综合类 | 66945篇 |
现状与发展 | 3篇 |
一般理论 | 1096篇 |
预防医学 | 227895篇 |
眼科学 | 67540篇 |
药学 | 216116篇 |
7篇 | |
中国医学 | 6181篇 |
肿瘤学 | 153068篇 |
出版年
2018年 | 29418篇 |
2017年 | 22714篇 |
2016年 | 25119篇 |
2015年 | 28315篇 |
2014年 | 40328篇 |
2013年 | 61324篇 |
2012年 | 82469篇 |
2011年 | 87134篇 |
2010年 | 51331篇 |
2009年 | 48917篇 |
2008年 | 82351篇 |
2007年 | 88031篇 |
2006年 | 89012篇 |
2005年 | 86077篇 |
2004年 | 83167篇 |
2003年 | 80008篇 |
2002年 | 78915篇 |
2001年 | 134737篇 |
2000年 | 139037篇 |
1999年 | 117109篇 |
1998年 | 33203篇 |
1997年 | 29902篇 |
1996年 | 29866篇 |
1995年 | 28740篇 |
1994年 | 26941篇 |
1993年 | 25097篇 |
1992年 | 94263篇 |
1991年 | 91592篇 |
1990年 | 88774篇 |
1989年 | 85835篇 |
1988年 | 79574篇 |
1987年 | 78187篇 |
1986年 | 74131篇 |
1985年 | 70484篇 |
1984年 | 53132篇 |
1983年 | 45176篇 |
1982年 | 26993篇 |
1981年 | 24075篇 |
1979年 | 49686篇 |
1978年 | 34972篇 |
1977年 | 29434篇 |
1976年 | 27859篇 |
1975年 | 29578篇 |
1974年 | 36183篇 |
1973年 | 34314篇 |
1972年 | 32232篇 |
1971年 | 29734篇 |
1970年 | 28120篇 |
1969年 | 26128篇 |
1968年 | 23796篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
74.
75.
TG Berger F Kiesewetter C Maczek N Bauer M Lueftl G Schuler M Simon Jr 《Journal of the European Academy of Dermatology and Venereology》2006,20(2):178-183
Vitiligo and psoriasis are both common skin disorders. However, psoriasis strictly confined to pre-existing vitiligo areas is rare and suggests a causal relationship. We report here on two patients with a strict anatomical colocalization of vitiligo and psoriasis. The histopathological examinations showed typical changes for both diseases together with a dense infiltrate of CD4+ and CD8+ T cells. By immunohistochemistry, intracytoplasmatic granzyme B and tumour necrosis factor alpha (TNF-alpha) were detected within the T-cell population, suggesting the functional activity of these cells and the creation of a local T helper 1 (Th1)-cytokine milieu. Additionally, in one patient we could identify anti-melanocytic T cells by tetramer staining and enzyme-linked immunospot (ELISPOT) analysis. These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-alpha and interferon-gamma (IFN-gamma), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis. 相似文献
76.
Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children.
AIM: Cardiovascular risk factors can be present in children and young adults. We previously found abnormal microvascular function in children who had glucose intolerance and insulin resistance. The aim of the present study was to investigate whether they also have abnormalities in left ventricular mass (LVM) and arterial stiffness. METHODS: We measured heart dimensions and LVM using echocardiography, and arterial stiffness using pulse wave analysis in 23 children with good glucose handling (postfeeding glucose: 3.9 to 5 mmol/L) and 21 with poor glucose handling (7.7 to 11.4 mmol/L). RESULTS: The time to pulse reflection was slightly shorter in the poorer glucose handlers (mean+/-SD: 143+/-10 vs 153+/-20 ms, P=0.04), suggestive of increased arterial stiffness. Also in this group, there were significant relationships between intraventricular septal thickness, blood pressure and body mass index, but not in the normal glucose handlers. CONCLUSIONS: We have found that normal children who are in the lowest quintile of glucose tolerance in comparison with their peers are exhibiting the first signs of arterial stiffening. In addition, we have seen the beginnings of a relationship between blood pressure, body mass index and left ventricular enlargement in this group. While these changes may not yet be clinically significant, their emergence might be further evidence of early predisposition to cardiovascular disease. 相似文献
77.
78.
79.
80.
D J Adam S Raptis R A Fitridge 《European journal of vascular and endovascular surgery》2006,31(2):151-156
BACKGROUND: This study examines trends in the presentation and surgical management of acute diabetic foot problems in a single institution. METHOD: Prospective audit of all diabetic patients who had a primary procedure for critical lower limb ischaemia (CLI) and/or foot sepsis between 1st January 1990 and 31st December 2002. Primary and secondary intervention, mortality and limb salvage rate within 6 weeks of the index procedure were recorded. RESULTS: There were 661 patients (417 men and 244 women of median age 69, range 31-99, years) with 799 affected limbs. CLI alone was present in 625 (78%) limbs, combined CLI and foot sepsis in 53 (7%) and foot sepsis alone in 121 (15%). The primary intervention was minor amputation in 323 (40%) limbs, revascularisation in 288 (36%), major amputation in 185 (23%) and sympathectomy in three limbs. Within 6 weeks, 125 (16%) limbs required secondary intervention, the peri-procedural mortality rate was 38 of 924 (4%), and the limb salvage rates for patients with CLI, combined CLI and sepsis and sepsis alone were 66, 66 and 80%, respectively. There was a significant decline in the proportion of patients presenting with CLI alone and a significant increase in the proportion presenting with combined CLI and sepsis and sepsis alone. In patients with CLI alone, there was a significant increase in the primary major amputation rate and a significant decline in the minor amputation rate with no significant change in the revascularisation rate. CONCLUSION: There has been a progressive decline in the proportion of patients presenting with CLI alone and a greater proportion of patients presenting with an element of foot sepsis. In patients with CLI alone, the primary major amputation rate has increased at the expense of a decline in minor amputation rate. 相似文献