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41.
42.
Pregnancy augments nitric oxide-dependent dilator response to acetylcholine in the human uterine artery 总被引:4,自引:1,他引:3
Nelson SH; Steinsland OS; Suresh MS; Lee NM 《Human reproduction (Oxford, England)》1998,13(5):1361-1367
The influence of pregnancy on the dilator effects of acetylcholine in the
isolated human uterine artery was investigated. Acetylcholine (0.1 nM to
0.1 microM) produced concentration- and endothelium-dependent relaxation of
norepinephrine (3 microM)-induced contraction. The relaxation was greater
in arteries from pregnant patients (P arteries) than from non-pregnant
patients (NP arteries). The maximal relaxation was 53.5+/-3.4% (n=21) in P
arteries and 23.5+/-2.5% (n=35) in NP arteries. In both P and NP arteries
the cholinergic relaxation was increased in the presence of superoxide
dismutase and greatly reduced in the presence of the nitric oxide synthase
inhibitors, NG-mono-methyl L-arginine (L-NMMA) and
L-nitro-arginine-methylester (L-NAME). The effect of these nitric oxide
synthase inhibitors was reversed by L- arginine. We conclude that pregnancy
enhances acetylcholine-induced nitric oxide synthesis and release in the
human uterine artery.
相似文献
43.
Atypical haemolytic uraemic syndrome treated with the complement inhibitor eculizumab: the experience of the Australian compassionate access cohort 下载免费PDF全文
44.
Dengue is a mosquito transmitted flaviviral infection which can give rise to severe haemorrhage (dengue haemorrhagic fever) and with capillary leakage induces hypovolaemic shock (dengue shock syndrome). Although dengue symptoms and complications have been known for many decades, there has only been one documented case of osteonecrosis of the maxilla which was treated by excision of the necrotic bone. In this case of dengue infection, extensive maxillary osteonecrosis and minimal root resorption appeared to follow factitious injury with a toothpick but resolved with non‐surgical management. 相似文献
45.
Katherine A. Barraclough Christine E. Staatz David W. Johnson Katie J. Lee Brett C. McWhinney Jacobus PJ. Ungerer Carmel M. Hawley Scott B. Campbell Diana R. Leary Nicole M. Isbel 《Transplant international》2012,25(11):1182-1193
This study analysed associations between tacrolimus, mycophenolic acid (MPA) and prednisolone exposures on day 4 and month 1 post kidney transplant and clinical outcomes. Area under the concentration‐time curve (AUC) for each drug was estimated using validated multiple regression‐derived limited sampling strategies. Multivariate logistic regression was used to associate drug exposure with clinical outcomes. One hundred and twenty subjects were studied. Between‐subject variability in dose‐adjusted exposure to each medication was high. Both day 4 tacrolimus and MPA exposures were independently predictive of delayed graft function (2.6 change in odds for a standard deviation (SD) increase in tacrolimus AUC0–12, P = 0.02; 0.23 change in odds for a SD increase in MPA AUC0–12, P = 0.02). Both day 4 MPA and total prednisolone exposures were independently predictive of rejection (0.20 change in odds for a SD increase in MPA AUC0–12, P = 0.04; 0.40 change in odds for a SD increase in total prednisolone AUC0–6, P = 0.03). Lowest tertile exposure to all three immunosuppressant medications imposed significantly higher odds of rejection [adjusted odds ratio 34.2 (95% CI 4.1, 284.4), P = 0.001]. This study highlights the importance of achieving early target exposure and suggests a potential role for individualized initial dosing or early therapeutic monitoring of all three immunosuppressive agents. 相似文献
46.
以正交设计筛选处方,研制了安心酮注射剂,考察了制剂的稳定性,有效期为2.85年。采用酸性染料比色法测定注射剂中安心酮的含量,平均回收率为98.7%(RSD=0.44%)。本品对离体灌流豚鼠心脏的作用与原药相似。 相似文献
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Alicia Lagarto Addis Bellma Juana Tillán Tatiana Gabilondo Isbel Guerra Zuleira Ocanto Micaela Couret Ricardo González 《Experimental and toxicologic pathology》2008,60(6):499-504
The potential of oral exposure to dolomite, a natural product that contains calcium and magnesium, to initiate teratogenesis was analyzed in Wistar rats. Animals received dolomite oral dosages of 500 and 1500mg/kg during the period of gestation from day 6-15 post conceptionem (p.c.). Maternal, embryo and fetal toxicity were evaluated. Dolomite exposure did not produce maternal toxicity assessed by clinical observations, body weight gain, hematology parameters and relative organs weight. Signs of embryo-fetal toxicity were not observed. Skeletal malformations and visceral variations were similar in control and dolomite-treated groups. On the other hand, slight increase was observed in fetal body weight in the dolomite-treated group. Treatment with dolomite resulted in significantly decreased incidences of unossified xiphisternum, incomplete ossification of xiphisternum and sternebrae. These effects could be caused by a beneficial influence of calcium and magnesium salts present in dolomite on ossification process. In conclusion, in this study we found that the oral exposure to rats of up to 1500mg/kg of dolomite during organogenesis did not induce significant maternal and embryo-fetal toxicity. 相似文献
50.
Penny F Whiting Marie E Weswood Anne WS Rutjes Johannes B Reitsma Patrick NM Bossuyt Jos Kleijnen 《BMC medical research methodology》2006,6(1):1-8