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排序方式: 共有628条查询结果,搜索用时 15 毫秒
61.
MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes 总被引:1,自引:1,他引:1 下载免费PDF全文
Vogl T Ludwig S Goebeler M Strey A Thorey IS Reichelt R Foell D Gerke V Manitz MP Nacken W Werner S Sorg C Roth J 《Blood》2004,104(13):4260-4268
MRP14 (S100A9) is the major calcium-binding protein of neutrophils and monocytes. Targeted gene disruption reveals an essential role of this S100 protein for transendothelial migration of phagocytes. The underlying molecular mechanism comprises major alterations of cytoskeletal metabolism. MRP14, in complex with its binding partner MRP8 (S100A8), promotes polymerization of microtubules. MRP14 is specifically phosphorylated by p38 mitogen-activated protein kinase (MAPK). This phosphorylation inhibits MRP8/MRP14-induced tubulin polymerization. Phosphorylation of MRP14 is antagonistically regulated by binding of MRP8 and calcium. The biologic relevance of these findings is confirmed by the fact that MAPK p38 fails to stimulate migration of MRP14(-/-) granulocytes in vitro and MRP14(-/-) mice show a diminished recruitment of granulocytes into the granulation tissue during wound healing in vivo. MRP14(-/-) granulocytes contain significantly less polymerized tubulin, which subsequently results in minor activation of Rac1 and Cdc42 after stimulation of p38 MAPK. Thus, the complex of MRP8/MRP14 is the first characterized molecular target integrating MAPK- and calcium-dependent signals during migration of phagocytes. 相似文献
62.
Irmgard Ziegler 《Monatsschrift für Kinderheilkunde》1965,56(1):1-66
Ohne Zusammenfassung
Mit 5 Abbildungen 相似文献
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64.
Irmgard Hoffmann Ludwig Lendle 《Naunyn-Schmiedeberg's archives of pharmacology》1948,205(2-3):223-242
Ohne ZusammenfassungHerrn Professor Dr. Wolfgang Heubner zum 70. Geburtstag gewidmet. 相似文献
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66.
Irmgard Schmidt 《Virchows Archiv : an international journal of pathology》1933,291(1-2):491-506
Ohne ZusammenfassungMit 9 Abbildungen im Text. 相似文献
67.
Hauser-Gerspach I Vadaszan J Deronjic I Gass C Meyer J Dard M Waltimo T Stübinger S Mauth C 《Clinical oral investigations》2012,16(4):1049-1059
Dental implants are prone to bacterial colonization which may result in bone destruction and implant loss. Treatments of peri-implant disease aim to reduce bacterial adherence while leaving the implant surface intact for attachment of bone-regenerating host cells. The aims of this study were to investigate the antimicrobial efficacy of gaseous ozone on bacteria adhered to various titanium and zirconia surfaces and to evaluate adhesion of osteoblast-like MG-63 cells to ozone-treated surfaces. Saliva-coated titanium (SLA and polished) and zirconia (acid etched and polished) disks served as substrates for the adherence of Streptococcus sanguinis DSM20068 and Porphyromonas gingivalis ATCC33277. The test specimens were treated with gaseous ozone (140 ppm; 33 mL/s) for 6 and 24 s. Bacteria were resuspended using ultrasonication, serially diluted and cultured. MG-63 cell adhesion was analyzed with reference to cell attachment, morphology, spreading, and proliferation. Surface topography as well as cell morphology of the test specimens were inspected by SEM. The highest bacterial adherence was found on titanium SLA whereas the other surfaces revealed 50-75% less adherent bacteria. P. gingivalis was eliminated by ozone from all surfaces within 24 s to below the detection limit (≥99.94% reduction). S. sanguinis was more resistant and showed the highest reduction on zirconia substrates (>90% reduction). Ozone treatment did not affect the surface structures of the test specimens and did not influence osteoblastic cell adhesion and proliferation negatively. Titanium (polished) and zirconia (acid etched and polished) had a lower colonization potential and may be suitable material for implant abutments. Gaseous ozone showed selective efficacy to reduce adherent bacteria on titanium and zirconia without affecting adhesion and proliferation of osteoblastic cells. This in vitro study may provide a solid basis for clinical studies on gaseous ozone treatment of peri-implantitis and revealed an essential base for sufficient tissue regeneration. 相似文献
68.
Binding of outer membrane (OM) preparations of the thermophilic Campylobacter species C. jejuni to epithelial cell membranes and extracellular matrix proteins were studied in an in vitro model system using enzyme-linked immunosorbent assay. The OM preparations exhibited significant binding to INT 407 intestinal cell membranes. The process of adhesion was modulated by enzymatic, chemical or immunological pretreatment of the bacteria. Following oxidation of the lipopolysaccharide (LPS) with sodium meta-periodate, the OM preparations essentially retained their binding properties. After pretreatment with proteinase K, the OM preparations lost their binding capacity and the apparent molecular mass of the major OM protein shifted from 42 to 24 kDa. Preincubation of C. jejuni bacteria with C. jejuni-specific antiserum reduced adhesion significantly; preincubation with LPS-specific monoclonal antibodies only to a minimal extent. The OM preparations also bound significantly to the extracellular matrix proteins collagen and fibronectin; however, they bound virtually no bovine serum albumin or horse serum. 相似文献
69.
Irmgard Bauer MN 《Journal of advanced nursing》1993,18(6):932-937
Morning shifts in Germany usually start at 6 00 a in Apart from the well-known effects of shiftwork on health and family/social life, the early rising tune poses additional problems Part of a study on the first hour of the morning shift is described in this paper Thirteen nurses on a female surgical and on a male medical ward were interviewed using a serru-structured interview guide The findings were obtained through phenomenological analysis Seven themes emerged from the results (a) the impact of rising early on the individual, (b) the detrimental effect of alternating shifts on well-being, (c) disturbances to personal life, (d) the rationale for early start, (e) consequences for patients, (f) suggestions for change, and (g) increased risk of leaving the job The findings suggest that the early start puts nurses under considerable stress Tradition rules the time-oriented and ritualized way of organizing work Further extensive research is recommended 相似文献
70.