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排序方式: 共有3925条查询结果,搜索用时 31 毫秒
31.
Inge Van de Walle Karen Silence Kevin Budding Liesbeth Van de Ven Kim Dijkxhoorn Elisabeth de Zeeuw Cafer Yildiz Sofie Gabriels Jean-Michel Percier Johanna Wildemann Jan Meeldijk Peter J. Simons Louis Boon Linda Cox Rob Holgate Rolf Urbanus Henny G. Otten Jeanette H.W. Leusen Peter Boross 《The Journal of allergy and clinical immunology》2021,147(4):1420-1429.e7
32.
Inge Lues Richard Vinke Hans-Joachim Schümann 《Naunyn-Schmiedeberg's archives of pharmacology》1984,326(3):273-277
Summary The interaction between rauwolscine and angiotensin II was investigated in the isolated mesenteric artery of the rabbit. Rauwolscine, known as an antagonist at 2-adrenoceptors, did not induce contraction itself but interacted with angiotensin to produce a facilitated response of the vascular tissue. In the presence of rauwolscine, the contractile response of the tissue to angiotensin was markedly enhanced. The degree of facilitation appeared to be dependent on the rauwolscine concentration used rather than that of angiotensin. Moreover, rauwolscine induced a concentration-dependent increase in tension (pD2=6.8) in the presence of even subcontractile concentrations of angiotensin (10–10 mol/l). This effect was not attributable to an indirect action involving presynaptic catecholamines, as revealed by the use of tissue strips from animals pretreated with reserpine or after chemical sympathectomy. Furthermore, an interaction via the prostaglandin system was excluded by negative results obtained with indomethacin. The agonistic effect of rauwolscine was significantly attenuated by phentolamine (1/2) but not by prazosin (1) or phenoxybenzamine when applied for only a short time. The 2-antagonist BDF 6143 behaved like rauwolscine whereas the 1-antagonist corynanthine, a stereoisomer of rauwolscine, did not. The results indicate that the rauwolscine effect is mediated by a receptor with 2-characteristics. In general, angiotensin appears to interfere with some process which determines the expression of a drug's intrinsic effect.This study was supported by a grant of the Deutsche Forschungsgemeinschaft 相似文献
33.
34.
Grad Roland Leger Daniel Kaczorowski Janusz Schuster Tibor Adler Samara Aman Marya Archibald Douglas Beaulieu Marie-Claude Chmelicek John Cornelissen Evelyn Delleman Bethany Hadj-Mimoune Sonia Horvey Samantha Macaluso Steven Mintsioulis Stephen Murdoch Stuart Ng Brian Papineau Alain Rangwala Sohil Rousseau Mathieu Rudkin Teresa Schabort Inge Schultz Karen Snow Pamela Wong Eric Wu Pearson Brailovsky Carlos 《Advances in health sciences education : theory and practice》2021,26(3):771-783
Advances in Health Sciences Education - Spaced education is a learning strategy to improve knowledge acquisition and retention. To date, no robust evidence exists to support the utility of spaced... 相似文献
35.
Inge Melchior Anouk van der Heijden Esther Stoffers Frits Suntjens Albine Moser 《Health expectations》2021,24(2):456
BackgroundCultural values are crucial to the practice and impact of patient and public involvement (PPI) in research.ObjectiveTo understand different PPI cultures among research teams and the impacts of PPI associated with each culture type.DesignA participatory action research design.Setting and participantsThe setting was 10 palliative care research projects. Seventeen patients and members of the public and 31 researchers participated.InterventionA programme consisting of four components: (1) training and coaching of patients and the public to prepare them for participation in research, (2) tailored coaching of the 10 research teams over 12‐18 months, (3) a community of practice, and (4) a qualitative evaluation.ResultsWe identified three cultures types: relationship cultures, task cultures, and control cultures. We identified four areas of impact: the project aim became more relevant to the target audience, methodological reliability increased, the research products were better able to reach the public, and the awareness increased, associated with behavioural changes, among researchers regarding PPI.DiscussionA relationship culture appears to be long‐lasting due to impacting the behaviours of the researchers during future projects. Different cultural types require different types of patients and researcher participants, assigned to different tasks.ConclusionsFurther research remains necessary to investigate the support required by researchers to enable relationship‐ and task‐oriented PPI cultures.Patient or public contributionPatient advocates and representatives contributed to our research team throughout the entire research process, as well as within the 10 implementation projects. 相似文献
36.
Schmitz Timo Meisinger Christa Kirchberger Inge Thilo Christian Amann Ute Baumeister Sebastian E. Linseisen Jakob 《European journal of epidemiology》2021,36(6):619-627
European Journal of Epidemiology - The aim of this study was to evaluate the impact of the COVID-19 pandemic lockdown on acute myocardial infarction (AMI) care, and to identify underlying stressors... 相似文献
37.
Recent experimental studies on the crystallization of calcium salts at different nephron levels support the theory that the
initial formation of calcium concrements starts with an intratubular crystallization of calcium phosphate (CaP) and calcium
oxalate (CaOx). CaP seems to be the initial crystallization product in pure CaP and mixed calcium phosphate–calcium oxalate
(CaPCaOx) concrements, with the formation of CaP crystals at a nephron level above the collecting duct. Urinary macromolecules
and cellular degradation products most probably promote this process. During the passage through the collecting duct, CaP
might partly or completely dissolve at the lower pH encountered there. This might result in an increased concentration of
calcium and hence an increased supersaturation with CaOx, which in turn can bring about a heterogeneous nucleation of CaOx
on or around preformed CaP crystals or crystal aggregates. The final result will be mixed CaOxCaP or pure CaOx concrements.
Pure CaOx concrements might also be the result of an initial CaOx crystallization at nephron levels above or in the collecting
duct under conditions with a high urinary excretion of oxalate. Whether intratubular crystallization of calcium salts results
in the formation of small harmless crystals excreted with urine or calcium stones appears to be determined by a complex process,
involving kinetic factors that influence crystal growth and crystal aggregation and crystal retention.
Received: 24 December 1998 / Accepted: 11 March 1999 相似文献
38.
To examine the effect of hydroxyapatite (HAP) seed crystals and urinary macromolecules on the crystallization under conditions
similar to those in the collecting duct, we evaporated 100 ml samples of salt solutions with an ion composition assumed to
correspond to that in the collecting duct without and with HAP seed crystals. The crystallization in seeded solutions was
assessed both with and without dialysed urine (dU). After evaporation the number and volume of crystals were recorded in a
Coulter Multisizer and the crystal morphology examined with scanning electron microscopy (SEM) and X-ray crystallography.
Addition of HAP crystals was apparently followed by an approximately 15–20% increase in heterogeneous nucleation of calcium
oxalate (CaOx). In these experiments SEM and X-ray crystallography showed a high percentage of CaOx in the precipitate. In
samples reduced to 40–69 ml, addition of dU to the collecting duct solution containing HAP seed resulted in a greater mean
(SD) number of crystals; 3895 (1841) in samples with dU and 1785 (583) in samples without. This was mainly explained by an
increased mean (SD) number of small crystals. The mean crystal volume was 17.8 (1.1) and 34.3 (9.1) in samples reduced to
40–69 ml with and without dU, respectively. This might reflect the inhibitory effect of dU on the growth and/or aggregation
of the CaOx-CaP precipitate or a promoted nucleation resulting in a large number of small crystals. It is concluded that calcium
phosphate formed above the collecting duct might induce heterogeneous nucleation of CaOx at lower levels of the renal collecting
system, and that urinary macromolecules are powerful modifiers of these processes.
Received: 8 July 1998 / Accepted: 12 March 1999 相似文献
39.
Heinz Helmers Heiner von Boetticher Inge Schmitz-Feuerhake 《European journal of nuclear medicine and molecular imaging》1982,7(7):324-326
A 3D-scanner for direct three-dimensional imaging using a --coincidence technique is presented. The characteristics of the system were demonstrated by isoresponse curves and modulation transfer functions. A phantom study showed the possibility of detecting cold nodes when they are invisible in normal scans in large subjects because of masking by overlying activity. 相似文献
40.
Heiervang E Hugdahl K Steinmetz H Inge Smievoll A Stevenson J Lund A Ersland L Lundervold A 《Neuropsychologia》2000,38(13):211-1713
A reduction or reversal of the normal leftward asymmetry of the planum temporale (PT) has been claimed to be typical of dyslexia, although some recent studies have challenged this view. In a population-based study of 20 right-handed dyslexic boys and 20 matched controls, we have measured the PT and the adjacent planum parietale (PP) region in sagittal magnetic resonance images. For the PT, mean left and right areas and asymmetry coefficients were compared. Since a PP area often could not be identified in one or both hemispheres, a qualitative comparison was used for this region. The total planar area (sum of PT and PP) was also compared between the two groups. A dichotic listening (DL) test with consonant–vowel syllables was administered to assess functional asymmetry of language. The results showed a mean leftward PT asymmetry in both the dyslexic and the control group, with no significant difference for the degree of PT asymmetry. Planned comparisons revealed however, a trend towards smaller left PT in the dyslexic group. In control children, but not in the dyslexic children, a significant correlation between PT asymmetry and reading was observed. A mean leftward asymmetry was also found for the total planar area, with no difference between the groups for the degree of asymmetry. Significantly fewer dyslexic children than control children showed a rightward asymmetry for the PP region. Both groups showed a normal right ear advantage on the DL task, with no significant difference for DL asymmetry. No significant correlation was observed between PT asymmetry and DL asymmetry. The present population-based study adds to recent reports of normal PT asymmetry in dyslexia, but indicates that subtle morphological abnormalities in the left planar area may be present in this condition. 相似文献