全文获取类型
收费全文 | 527篇 |
免费 | 35篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 23篇 |
妇产科学 | 10篇 |
基础医学 | 73篇 |
口腔科学 | 2篇 |
临床医学 | 33篇 |
内科学 | 200篇 |
皮肤病学 | 7篇 |
神经病学 | 15篇 |
特种医学 | 4篇 |
外科学 | 49篇 |
预防医学 | 30篇 |
眼科学 | 1篇 |
药学 | 58篇 |
中国医学 | 1篇 |
肿瘤学 | 63篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 20篇 |
2021年 | 12篇 |
2020年 | 10篇 |
2019年 | 17篇 |
2018年 | 12篇 |
2017年 | 7篇 |
2016年 | 15篇 |
2015年 | 22篇 |
2014年 | 22篇 |
2013年 | 29篇 |
2012年 | 62篇 |
2011年 | 38篇 |
2010年 | 23篇 |
2009年 | 17篇 |
2008年 | 29篇 |
2007年 | 20篇 |
2006年 | 34篇 |
2005年 | 26篇 |
2004年 | 22篇 |
2003年 | 17篇 |
2002年 | 19篇 |
2001年 | 4篇 |
2000年 | 8篇 |
1999年 | 2篇 |
1998年 | 5篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 7篇 |
1990年 | 8篇 |
1989年 | 3篇 |
1988年 | 9篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1982年 | 3篇 |
1980年 | 1篇 |
1979年 | 9篇 |
1978年 | 9篇 |
1977年 | 1篇 |
1976年 | 3篇 |
排序方式: 共有571条查询结果,搜索用时 15 毫秒
21.
22.
Endocrine function and bone disease during long‐term chelation therapy with deferasirox in patients with β‐thalassemia major
下载免费PDF全文
![点击此处可从《American journal of hematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Maddalena Casale Serena Citarella Aldo Filosa Elisa De Michele Francesco Palmieri Alfonso Ragozzino Giovanni Amendola Umberto Pugliese Immacolata Tartaglione Filomena Della Rocca Patrizia Cinque Bruno Nobili Silverio Perrotta 《American journal of hematology》2014,89(12):1102-1106
Iron overload in β‐thalassemia major (TM) typically results in iron‐induced cardiomyopathy, liver disease, and endocrine complications. We examined the incidence and progression of endocrine disorders (hypothyroidism, diabetes, hypoparathyroidism, hypogonadism), growth and pubertal delay, and bone metabolism disease during long‐term deferasirox chelation therapy in a real clinical practice setting. We report a multicenter retrospective cohort study of 86 transfusion‐dependent patients with TM treated with once daily deferasirox for a median duration of 6.5 years, up to 10 years. No deaths or new cases of hypothyroidism or diabetes occurred. The incidence of new endocrine complications was 7% (P = 0.338, for change of prevalence from baseline to end of study) and included hypogonadism (n = 5) and hypoparathyroidism (n = 1). Among patients with hypothyroidism or diabetes at baseline, no significant change in thyroid parameters or insulin requirements were observed, respectively. Mean lumbar spine bone mineral density increased significantly (P < 0.001) and the number of patients with lumbar spine osteoporosis significantly decreased (P = 0.022) irrespective of bisphosphonate therapy, hormonal replacement therapy, and calcium or vitamin D supplementation. There were no significant differences in the number of pediatric patients below the 5th centile for height between baseline and study completion. Six pregnancies occurred successfully, and four of them were spontaneous without ovarian stimulation. This is the first study evaluating endocrine function during the newest oral chelation therapy with deferasirox. A low rate of new endocrine disorders and a stabilization of those pre‐exisisting was observed in a real clinical practice setting. Am. J. Hematol. 89:1102–1106, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
23.
Simone Lanini Paola Scognamiglio Raffaella Pisapia Claudia Minosse Alessandro Agresta Giuseppe Ippolito 《International journal of antimicrobial agents》2019,53(5):559-563
Chronic hepatitis C (CHC) is a complex disease that can affect different metabolic processes, including glucose and lipid metabolic pathways, with a significant impact on the development of heart disease and stroke. Recent therapy with direct-acting antivirals (DAAs), beyond its high efficacy on CHC eradication, showed a beneficial impact on glucose and lipid metabolism. This review aimed to describe current evidence regarding the association between hepatitis C virus (HCV) infection and impairment of glucose and lipid metabolism and also discusses potential public-health implications in light of the new DAA therapies and their availability at a global level. The excellent safety profile and efficacy of DAAs offer an exceptional opportunity to control the HCV pandemic at a global level and represent an opportunity for developing an operational research framework aimed at investigating the complex dynamics between host, pathogen and therapy that lead to metabolic damage in subjects with infectious diseases. 相似文献
24.
25.
Annamaria Perna Immacolata Intaglietta Amalia Simonetti Emilio Gambacorta 《Bulletin of environmental contamination and toxicology》2014,92(3):253-258
The aim of the study was to quantify the cadmium (Cd), lead (Pb), chromium (Cr) and arsenic (As) contents in ninety honey samples from nine areas of southern Italy. Results showed that As content was below the detection limit, while Cd, Pb, and Cr contents were below the recommended maximum acceptable levels. Mean Cd, Pb, and Cr contents were 0.013, 0.289 and 0.707 mg kg?1, respectively. The metal contents in honey varied greatly depending on considered area. Correlations between the metals were statistically significant (p < 0.05), suggesting that polluting sources involve the simultaneous presence of metals in honey. 相似文献
26.
Antonio Cicione Francesco Cantiello Giuseppe Ucciero Andrea Salonia Immacolata Madeo Ilaria Bava Antonio Aliberti Rocco Damiano 《International journal of urology》2014,21(8):763-768
Restoring the bladder glycosaminoglycans layer has recently been introduced as prophylactic treatment for recurrent urinary tract infections. Herein, we analyze the latest main clinical and experimental studies to support this therapeutic option. An electronic research was carried out in the most common databases in order to identify any published studies. Retrieved studies were categorized as experimental or clinical according to their setting. For the clinical studies, the evidence level was assigned. A total of 13 laboratory studies showed how bladder glycosaminoglycans instillations act: attenuation of the inflammation process, reduction of bladder contraction amplitude and frequency, reduction of epithelium damage, and lower bacterial growth in urine and tissue samples. Likewise, two randomized clinical trials with grade 2 evidence level and two case series with grade 4 evidence level reported glycosaminoglycans as an alternative to reduce episodes and to prolong recurrence time in patients with recurrent urinary tract infections. At least 12 months of follow up was completed. No serious adverse events were reported. Compared with a placebo, in one randomized study a significantly higher maximum cystometric capacity was obtained, whereas in the other study a significant increase in quality of life scores was reported too. An improvement in the urinary symptoms score was reported by the two randomized trials. Although the clinical use of glycosaminoglycans replacement therapy for recurrent urinary tract infections is supported by a small number of clinical studies with different evidence levels, the laboratory studies show that glycosaminoglycans could have a protective role against inflammatory factors, supporting the idea “to restore the glycosaminoglycans bladder layer to prevent chronic disease course”. 相似文献
27.
28.
Valentina De Cosmi Alessandra Mazzocchi Veronica DOria Alessandro Re Giulia Carla Immacolata Spolidoro Gregorio P. Milani Cristiana Berti Silvia Scaglioni Claudia Giavoli Silvia Bergamaschi Giulia Rodari Eriselda Profka Roberto Colombo Carlo Agostoni 《Nutrients》2022,14(7)
Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels. 相似文献
29.
Domenico Angelucci Nicola Tinari Antonino Grassadonia Ettore Cianchetti Giampiero Ausili-Cefaro Laura Iezzi Marinella Zilli Simona Grossi Lucia Anna Ursini Maria Teresa Scognamiglio Graziella Castrilli Michele De Tursi Paolo Noccioli Pasquale Cioffi Stefano Iacobelli Clara Natoli 《Journal of cancer research and clinical oncology》2013,139(2):269-280
Purpose
The aim of this study is to evaluate the long-term outcome of patients with locally advanced breast cancer treated with neoadjuvant systemic chemotherapy (NST) in routine clinical practice.Methods
Four hundred and nine patients were identified between January 1999 and December 2011. All patients received NST followed by surgery, adjuvant treatments and radiotherapy, as appropriate.Results
At Kaplan–Meier analysis, patients with surgical stage III disease were more likely to develop distant metastasis and die from breast cancer (p < 0.001). Luminal A and luminal B/HER2-negative patients had better prognosis; moreover, patients with hormone receptor (HR)-positive tumors had a significantly longer DRFS (p < 0.0049) and OS (p < 0.0001) compared with patients with HR-negative tumors as well as patients who underwent breast-conserving surgery (DRFS and OS: p < 0.001). In multivariate analysis, HR negativity (p < 0.001 for both DRFS and OS), mastectomy (DRFS: p = 0.009; OS: p = 0.05) and stage III disease (DRFS: p < 0.001; OS: p = 0.003) were associated with shorter DRFS and OS.Conclusions
HR negativity, mastectomy and pathological stage III disease are the variables independently associated with a worse outcome in our cohort of patients. These data are of high interest since they derive from a very heterogeneous group of patients, treated with different neoadjuvant/adjuvant regimens outside of clinical trials and with a long follow-up period. 相似文献30.
The unusual echocardiographic findings are described in a case of congenital interventricular septal aneurysm. The aneurysm involved the middle part of the interventricular septum and was associated with a cleft of the mitral valve and an atrial septal defect but with no evidence of an atrioventricular septal defect. There was extensive fibroelastosis of the right ventricle. The patient presented with brief runs of ventricular tachycardia. 相似文献