硫脲、硅酸盐对碳钢钝化作用的影响

本文利用化学方法,通过碳钢在含有ZnSO4,Na2HPO4与（NH2）2CS或Na2SiO3三者复配得4mol/L的（NH4）2CO3溶液中的阳极极化曲线的测定,分析得出：在特定的环境中,ZnSO4,Na2HPO4与9NH2）2CS或Na2SiO3三者复配物对碳钢都有较理想的钝化使用。     

NMDA受体与NOS在大鼠脊髓中间外侧柱的定位和生后发育

目的 探讨N-甲基-天冬氨酸受体（NMDAR1和NMDAR2A/B亚基）、一氧化氮合酶（NOS）及还原型辅酶Ⅱ硫辛酰胺脱氢酶（NADPH-d）活性在大鼠脊髓中间外侧柱（IML）的定位与生后发育特征。方法 在甲醛固定的脊髓切片上,进行ABC法免疫染色和NADPH-d组织化学反应与半定量分析。结果 MMDAR1,NMDAR2A/B,NOS I和NADPH-d反应产物丰富地分布于IML,主要定位于神经元胞体、树突和轴突样纤维终末。在生后早期发育中它们具有明显的动态变化,生后7d(P7）有微弱或中等的表达,随后逐渐上调,P21或P28达到高峰,然后保持于此水平于成体动物。结论 NMDA受体-NO通路可能是脊髓交感节前神经元一条重要的细胞内信号途径,并参与神经元生后发育成熟的调控过程。     

卵巢癌患者手术前后IL-2,sIL-2R及mIL-2R水平改变的临床意义

探讨卵巢癌患的细胞状态以及ＩＬ－２血清游离白细胞介素－２受体,外周血单个核细胞膜结构型白细胞介素－２受体与临床的关系。方法＾３Ｈ－ＴｄＲ参入法测３１例卵巢癌患ＩＬ－２产生水平,ＥＬＩＳＡ法检测血清ｓＩＬ－２Ｒ水平,ＡＰＡＡＰ免疫组化检测外周血单个核细胞膜结合型ＩＬ－２Ｒ表达细胞。     

Estrogen replacement therapy among elderly women: results from the 1995 medicare current beneficiary survey

Research Objectives: To develop population-based estimates of estrogen replacement therapy use rates in 1995 among women over age 65 living in the community; to estimate the impact of socioeconomic and health characteristics on estrogen use. Method: Estimates are based on a large, nationally representative sample of Medicare beneficiaries; detailed self-report data were merged with Medicare claims. Results: Overall, 13.1% of women reported use of estrogen replacement therapy in 1995. Estrogen users were more likely to be white, age 65–74, with private insurance, high income, history of osteoporosis and heart problems, no history of breast cancer, and a patient of gynecologists. Conclusions: Estrogen use was substantially lower among the socioeconomically disadvantaged, controlling for medical history variables, suggesting considerable inequity in access to estrogen replacement therapy treatment.     

轻、中度缺氧对事件相关电位的影响及不同刺激模式的比较

目的 观察轻、中度缺氧对脑事件相关电位（ＥＲＰ）的影响,比较不同刺激模式发的ＥＲＰ对缺氧的敏感性,方法１２名受试者在地面、２５００ｍ和４３００ｍ匠心同度（吸放低氧混合气）分别进行视觉Ｏｃｄｄｂａｌｌ、Ｓｔｅｒｎｂｅｒｇ记忆量（ＭＳＥＴ）为１ 和ＭＳＥＴ为３的任务测试,记录ＥＲＰ的Ｐ３潜伏期、波幅和反应时（ＲＴ）及反应错误率（ＥＲ）。结果 ４３００ｍ高度缺氧时Ｐ３潜伏期显著延长,任务难度较大时ＥＲ增     

Growth of human tumor cells in macroporous microcarriers results in p53-independent, decreased cisplatin sensitivity relative to monolayers

Multicellular contact has been shown to influence the in vitro sensitivity of cells to drug treatment. We investigated the use of macroporous gelatin microcarriers, CultiSpher-G, as a convenient laboratory system for the molecular analysis of this "contact effect". We determined that human A549 cells can be grown in CultiSphers with growth and cell cycle parameters similar to those of monolayers. In addition, cells in CultiSphers express less p27/kip1, an indicator of cell cycle arrest, than equivalent cells in monolayers. When treated with drugs, A549 cells grown in CultiSphers or monolayers accumulate equivalent amounts of platinum-DNA adducts and similar amounts of doxorubicin. Moreover, A549 and KB-3-1 cells in CultiSphers have significantly decreased sensitivity to cis-platinum(II)diammine dichloride (cisplatin), 4-hydroperoxycyclophosphamide, doxorubicin, and paclitaxel (taxol) compared with cells in monolayers when assayed by clonogenic survival. Cisplatin treatment in monolayers or CultiSphers did not result in apoptotic cell death. In contrast, paclitaxel caused a significant amount of sub-G1 DNA, an indicator of apoptosis, which was diminished when cells were grown in CultiSphers compared with monolayers. When grown in CultiSphers, cells with abrogated p53 function (A549/16E6 and NCI-H1299) were less sensitive to cisplatin than the corresponding monolayer cells, indicating that the decrease in sensitivity is p53 independent. Taken together, the data suggest that CultiSpher-G microcarriers are a useful in vitro system to examine the effects of three-dimensional cell contact on drug sensitivity of human tumor cells.     

Back to the future for wound care?

The European Renaissance was a time of enormous change and rapid progress in the arts, sciences, and medicine. A glimpse of wound care in the last phase of the European Renaissance is provided by the analysis of work by Wilhelm Fabry, the "father of German surgery," as provided in his book De Combustionibus ("Burns") which details his range of treatments for the burn wound, as well as his approach to the later problems of scarring and contracture. We describe some of the historic events which may have stimulated Fabry's writings, in particular, the influences passed down from the medical school of Padua which thereby advanced the cause of wound care and surgery. Finally, we briefly explore the potential of such an approach to the works of our medical forefathers.     

Reading, Demographic, Social and Psychological Factors Related to Pre-adolescent Smoking and Non-smoking Behaviors and Attitudes

The purpose of this study was to examine reading, demographic, social and psychological factors related to pre-adolescent smoking and non-smoking behaviors and attitudes. The school-home humanistic education program was implemented in a large, urban public school system. It stressed responsible decision-making, increased self-esteem and the inter-relationships among the acquisition of knowledge of the consequences of smoking, personal feelings, family relationships and behavior. The results showed that family involvement was necessary to affect smoking attitudes and behaviors. Of all the variables studied, reading had a most pervasive relationship. Peer influence and self-esteem also were related to smoking knowledge, smoking attitude, future smoking intentions and the "purchase" of cigarettes. Two of several conclusions drawn from the results are: 1. Family involvement is necessary to affect attitudes and behaviors. 2. Health education research that does not investigate the relationship between program outcomes and reading achievement may be misleading.     

疏肝起萎汤配合夫妻性感集中训练疗法治疗心因性勃起功能障碍147例疗效观察

目的:观察疏肝起萎汤配合夫妻性感集中训练疗法治疗心因性勃起功能障碍的临床疗效。方法:将406例患者随机分为3组,治疗组147例采用疏肝起萎汤(由柴胡、枳壳、白芍、淫羊藿、蜈蚣、川芎、陈皮、炙甘草组成)配合夫妻性感集中训练疗法治疗;对照Ⅰ组132例采用疏肝起萎汤治疗;对照Ⅱ组127例采用家庭性感集中训练疗法治疗。观察3组综合疗效和症状改善情况。结果:治疗组痊愈99例,好转37例,痊愈率67.35％,总有效率92.52％;对照Ⅰ组痊愈49例,好转34例,痊愈率37.12％,总有效率62.88％;对照Ⅱ组痊愈53例,好转36例,痊愈率41.70％,总有效率70.08％。治疗组与对照Ⅰ组、对照Ⅱ组痊愈率、总有效率比较,差异均有显著性意义(P<0.05)。结论:疏肝起萎汤配合夫妻性感集中训练疗法治疗心因性勃起功能障碍,疗效确切。