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41.
Harvesting sufficient progenitor cells from bone marrow (BM) for pediatric patients is a challenging process, especially from
smaller donors. Growth factor administration to donors prior to harvest results in an enrichment of the graft and leads to
early engraftment. A total of 41 patients received a human leukocyte antigen-identical sibling transplantation using granulocyte
colony-stimulating factor (G-CSF)-primed BM. All donors received G-CSF 10 μg/kg/day for 2 days prior to harvest. The median
weight difference between donor and recipient was 3.9 kg (range, −29.8 to 32 kg), and the median number of CD34+ cells harvested was 4.16 × 106/kg (range, 1.17–31.9 × 106/kg). The median time to neutrophil engraftment was 12 days (range, 10–27 days), and the time for platelet engraftment was
20 days (range, 12–64 days). The cumulative incidence of acute grade 2 to 3 graft-versus-host disease (GVHD) and chronic GVHD
was 4.9% and 5.1%, respectively. An analysis according to the weight difference between donor and recipient showed there was
no significant difference in harvested CD34+ cell dose and in time required for engraftment between smaller and heavier donor recipients. G-CSF-primed BM allows successful
engraftment and provides a valuable alternative to unstimulated BM and peripheral blood stem cells with good engraftment and
tolerable GVHD even in patients with smaller donors. 相似文献
42.
Eun Jin Bae In Hwan HongSung Pyo Park Hyoung Kyun KimKyung Wha Lee Jae Ryong Han 《Burns : journal of the International Society for Burn Injuries》2013
Background
Ocular complications from electrical burns are uncommon. Thus far, there has been no systematic review on ocular electrical trauma with emphasis on patients’ ophthalmic complications and visual symptoms. Herein, we retrospectively analyzed records of patients with electrical injuries to summarize the ophthalmic characteristics and explore their relationships with visual symptoms.Methods
We collected the medical records of 102 patients who consulted from 557 electrical burn patients between 2004 and 2010. Ophthalmic, systemic and demographic factors associated with electrical burns were identified in the patient who underwent the ophthalmic consultations. Two sets of comparisons were used to determine the demographic and systemic factors that were related to ophthalmic complications and the subjective outcome of visual impairment.Results
There were 53 eyes (29 patients) with ophthalmic complication were identified. Corneal epithelial erosion was the most common ocular electrical injury and the primary reason for subjective visual symptoms. Electrical burns affecting the head and neck were significantly related to subjective symptoms of visual disturbances.Conclusion
Present study indicates that earlier involvement of ophthalmologists in the case of any patient who has suffered a facial burn is advisable. Appropriate management would be helpful to prevent future complications and alleviate visual symptoms. 相似文献43.
Sung Rak Lee Hyoung Won Jang Dhong Won Lee Sang Wook Nam Jeong Ku Ha Jin Goo Kim 《Clinics in Orthopedic Surgery》2013,5(3):188-194
Background
The purpose of this study is to report a modified transtibial technique to approach the center of anatomical femoral footprint in anterior cruciate ligament (ACL) reconstruction and to investigate the accurate femoral tunnel position with 3-dimensional computed tomography (3D-CT) and radiography after reconstruction.Methods
From December 2010 to October 2011, we evaluated 98 patients who underwent primary ACL reconstruction using a modified transtibial technique to approach the center of anatomical femoral footprint in single bundle ACL reconstruction with hamstring autograft. Their femoral tunnel positions were investigated with 3D-CT and radiography postoperatively. Femoral tunnel angle was measured on the postoperative anteroposterior (AP) radiograph and the center of the femoral tunnel aperture on the lateral femoral condyle was assessed with 3D-CT according to the quadrant method by two orthopedic surgeons.Results
According to the quadrant method with 3D-CT, the femoral tunnel was measured at a mean of 32.94% ± 5.16% from the proximal condylar surface (parallel to the Blumensaat line) and 41.89% ± 5.58% from the notch roof (perpendicular to the Blumensaat line) with good interobserver (intraclass correlation coefficients [ICC], 0.766 and 0.793, respectively) and intraobserver reliability (ICC, 0.875 and 0.893, respectively). According to the radiographic measurement on the AP view, the femoral tunnel angles averaged 50.43° ± 7.04° (ICC, 0.783 and 0.911, respectively).Conclusions
Our modified transtibial technique is anticipated to provide more anatomical placement of the femoral tunnel during ACL reconstruction than the former traditional transtibial techniques. 相似文献44.
45.
Geena Kim Gil Ho Ban Hyoung Doo Lee Si Chan Sung Hyungtae Kim Kwang Ho Choi 《Pediatrics international》2016,58(7):648-651
Pseudoaneurysm in the left ventricular outflow tract is a rare complication occurring after cardiac surgery. We report on the successful percutaneous device closure of a pseudoaneurysm in the left ventricular outflow tract, which developed in a 23‐month‐old girl after resection of a subaortic ridge. The pseudoaneurysm was closed using an Amplatzer Vascular Plug II. 相似文献
46.
PURPOSE: This study aimed to evaluate the cancer detection rate in a Korean population with prostate-specific antigen (PSA) levels greater than or equal to 20.0 ng/mL. MATERIALS AND METHODS: A total of 174 men 50 to 79 years old (median 69) included in the study. The median prostate volume of the patients was 44.8 mL (range 14.1 to 210.0) and their serum PSA ranged from 20.0 to 9725.0 ng/mL (median 44.8). RESULTS: Of 174 men 141 (81.0%) were diagnosed with prostate cancer on initial biopsy. In the total number of patients, the positive predictive value (PPV) was 62.9% for PSA 20 to 29.9, 72.7% for PSA 30 to 39.9 and 100% for PSA 40 to 49.9 ng/mL. In patients with an abnormal digital rectal examination (DRE), the values for these PSA ranges increased to 89.5%, 91.7% and 100%, respectively. The PPV was 81.0% for PSA cutoff of 20, 89.2% for a cutoff of 30, 95.4% for a cutoff of 40, and 94.7% for a cutoff of 50 ng/mL. In conjunction with an abnormal DRE, the values for these PSA cutoffs increased to 95.9%, 98.1%, 100%, and 100%, respectively. CONCLUSION: Our data suggest the ability to predict the presence of prostate cancer reliably on initial biopsy when PSA threshold is greater than or equal to 50 ng/mL. This PSA threshold may be lowered to 40 ng/mL in the presence of an abnormal DRE. In Korean men with high PSA, the detection rate of prostate cancer on biopsy appears to be comparable to that for American men. 相似文献
47.
48.
Jung-Hoon Park MS Ho-Young Song MD Soo Hwan Kim BS Ji Hoon Shin MD Jin Hyoung Kim MD Byung Sik Kim MD Jeong Hwan Yook MD 《Annals of surgical oncology》2014,21(6):2036-2043
Purpose
The purpose of this study was to assess the technical feasibility and clinical effectiveness of expandable metallic stent placement in 196 patients with recurrent malignant obstruction in their surgically altered stomach.Methods
The 196 patients were treated using five different types of gastric surgery performed for gastric cancer: total gastrectomy (type 1) in 73 patients; distal gastrectomy with gastroduodenostomy (type 2) in 39 patients; distal gastrectomy with a Roux-en-Y gastrojejunostomy (type 3) in 21 patients; distal gastrectomy with a gastrojejunostomy (type 4) in 49 patients; and palliative gastrojejunostomy for unresectable gastric cancer (type 5) in 14 patients. The technical and clinical success rates, complications, dysphagia score, and influence of chemotherapy were evaluated and the complications compared between the two stent types. The overall survival and stent patency were calculated using the Kaplan–Meier method.Results
Stent placement was technically successful in 192 of 196 patients (97.9 %), with 184 of the 192 patients (95.8 %) showing symptomatic improvement. The mean dysphagia score improved from 3.24 ± 0.64 to 1.48 ± 0.82 (p < 0.001). The complication rate was 25 %. The incidence of stent migration was significantly higher in fully covered stents and in patients who underwent chemotherapy (p < 0.001 and p = 0.005, respectively). Chemotherapy was significantly associated with an increase of survival (p < 0.001). The median survival and stent patency were 131 and 90 days, respectively.Conclusion
Placement of expandable metallic stents in patients with recurrent cancer after a surgically altered stomach is technically feasible and clinically effective. Chemotherapy was associated with increased stent migration and prolonged survival. 相似文献49.
Hyoung Eun Chang Mi Youn Park Haena Jang Shinae Ahn Hyo-Jeong Yoon 《Nursing outlook》2019,67(5):567-577
BackgroundIn order to improve organizational culture and job outcomes, it is important to characterize and better understand the relationship between aggression and verbal abuse among nurses.PurposeTo examine the relationships among demands at work, aggression, and verbal abuse among nurses.MethodsA cross-sectional study was conducted using survey data from three tertiary hospitals located in South Korea. Sixteen nursing units were selected and 378 nurses’ data were used as the final sample. The relationships were examined by multiple linear or logistic regression analyses.FindingsMore than 70% of the nurses had experienced at least 1 type of verbal abuse. Higher physical aggression and hostility were significantly related to greater verbal abuse experience.ConclusionTo prevent the vicious cycle of victims becoming perpetrators, it is necessary to develop and implement concrete strategies to manage verbal abuse and aggression among nurse colleagues. 相似文献
50.
Usefulness of Frequency Domain Optical Coherence Tomography Compared with Intravascular Ultrasound as a Guidance for Percutaneous Coronary Intervention
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In‐Cheol Kim M.D. Ph.D. Hyuck‐Jun Yoon M.D. Ph.D. Eun‐Seok Shin M.D Ph.D. Min‐Seok Kim Jincheol Park Ph.D. Yun‐Kyeong Cho M.D. Ph.D. Hyoung‐Seob Park M.D. Hyungseop Kim M.D. Ph.D. Chang‐Wook Nam M.D. Ph.D. Seong‐Wook Han M.D. Ph.D. Yoon‐Nyun Kim M.D. Ph.D. Kwon‐Bae Kim M.D. Ph.D. Seung‐Ho Hur M.D. Ph.D. 《Journal of interventional cardiology》2016,29(2):216-224