The value of tumor microenvironment of metastasis in gastric cancer

目的 研究胃癌中是否存在肿瘤微环境转移(tumor microenvironment of metastasis,TMEM)及其与胃癌血道转移的相关性.方法 采用免疫组化双染法同时标记巨噬细胞和内皮细胞,计数26例远处转移及其配对26例无远处转移胃癌组织中TMEM密度.结果 (1)TMEM存在于胃癌组织中;(2)TMEM与分化程度、临床分期明显相关(P<0.001,P=0.006),与肿瘤大小、Lauren分型、淋巴结转移等其他临床病理特点无关(P均＞0.05);(3)TMEM与有无远处转移呈正相关(P<0.001).结论 证实胃癌中存在TMEM,TMEM密度可以预测胃癌血道转移,有望成为评估胃癌血道转移危险性的新预测指标.     

Sublobectomy Versus Lobectomy for Stage I Non-Small-Cell Lung Cancer,A Meta-Analysis of Published Studies

Background  

The selection of surgeries for patients with stage I NSCLC remains controversial. We evaluated the effectiveness of different surgeries for stage I NSCLC through a meta-analysis of studies that compared sublobectomy with lobectomy.     

Quantitative Evaluation of Translational Medicine Based on Scientometric Analysis and Information Extraction

Designed to advance the two‐way translational process between basic research and clinical practice, translational medicine has become one of the most important areas in biomedicine. The quantitative evaluation of translational medicine is valuable for the decision making of global translational medical research and funding. Using the scientometric analysis and information extraction techniques, this study quantitatively analyzed the scientific articles on translational medicine. The results showed that translational medicine had significant scientific output and impact, specific core field and institute, and outstanding academic status and benefit. While it is not considered in this study, the patent data are another important indicators that should be integrated in the relevant research in the future.     

局部麻醉下经腹膜前无张力疝修补术20例的疗效

目的:探讨局麻下腹膜前腹股沟疝修补术的技术要点和临床疗效。方法:对20例局部麻醉下行腹膜前腹股沟疝修补术患者的资料进行回顾性分析。结果:20例患者术后恢复快,随访时间6～14个月,无复发。结论:局麻下腹膜前腹股沟疝修补术是一种操作较简便,术后复发率低的一种疝修补术,尤其适合于合并多种慢性疾病的老年患者,为腹股沟疝患者提供了一种理想的治疗方法。     

Circumstances preceding the suicide of Asian Pacific Islander Americans and White Americans

This study examined the circumstances preceding suicide among Asian and Pacific Islander Americans (APIAs) and White American decedents using data from the National Violent Death Reporting System in the United States. After controlling for gender and age, APIAs had lower rates of recent disclosure of suicide ideation, recent mental health treatment, recent mental health problems, and intimate partner problems, but higher rates of school problems than White Americans. There were also significant Race?×?Age moderation effects for recent mental health, financial, and school problems and a significant Race?×?Gender moderation effect for intimate partner problems.     

Expression of RRM1 and RRM2 as a novel prognostic marker in advanced non-small cell lung cancer receiving chemotherapy

The aim of this study was to examine the prognostic value of BRCA1, RRM1, and RRM2 in patients with non-small cell lung cancer (NSCLC) who received adjuvant chemotherapy. A total of 418 patients who underwent curative pulmonary resection were obtained between January 2007 and November 2009. The relative cDNA quantification for BRCA1, RRM1, and RRM2 was conducted using a fluorescence-based, real-time detection method, and β-actin was used as a reference gene. The low expression of RRM1 and RRM2 significantly increased the platinum-based chemotherapy response (For RRM1: odds ratio (OR)?=?2.09, 95 % confidence interval (CI)?=?1.38–3.18; For RRM2: OR?=?1.64, 95 % CI?=?1.09–2.48). The univariate analysis indicated that low expression of RRM1 attained a longer time to progression and overall survival time, with HR (95 % CI) of 0.50 (0.33–0.77) and 0.60 (0.39–0.92), respectively. Similarly, low expression of RRM2 had a longer time to progression and overall survival, with HR (95 % CI) of 0.57 (0.38–0.86) and 0.47 (0.31–0.71), respectively. In conclusion, low expression of RRM1 and RRM2 could be used to predict the treatment response to platinum-based chemotherapy and survival in NSCLC. The RRM1 and RRM2 could substantially contribute to the future design of individualized cancer treatment in NSCLC patients.