Efficacy and safety of heat-sensitive moxibustion in the treatment of neurogenic bladder after spinal cord injury: A protocol for systematic review and meta-analysis

Background:Spinal cord injury (SCI) is one of the most disabling and destructive neurological diseases. Neurogenic bladder dysfunction (NBD) is one of the serious complications after SCI, 80% of patients after SCI will have neurogenic bladder symptoms. NBD after SCI may lead to urinary retention, urinary incontinence, and urinary tract infection. In severe cases, it can lead to renal failure or even death. NBD after SCI not only seriously affects the patient''s quality of life but also physical and mental health. NBD after SCI is a social and medical problem. In recent years, more and more clinical studies prove that heat-sensitive can improve the clinical symptoms of NBD after SCI. Therefore, this article conducts a systematic evaluation and meta-analysis on the efficacy and safety of heat-sensitive moxibustion in treating NBD after SCI.Methods:Search 8 electronic databases including PubMed, Embase, Web of Science, The Cochrane Library, Clinical Trials, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and China Biomedical Literature Database. We will search above electronic databases from the inception to May 2021, without any language restriction. Clinical randomized controlled trials containing heat-sensitive moxibustion for NBD after SCI and eligible interventions(s) and outcome(s) were included, with no limitation of language and publication status. Two researchers will independently conduct literature search, screening, information extraction, quality assessment, and data analysis. Review Manager 5.3 software will be used for statistical analysis.Results:The findings will be submitted to a peer-reviewed publication.Conclusion:This systematic review and meta-analysis will provide a standard clinical decision-making guideline for heat-sensitive moxibustion treatment of NBD after SCI.INPLASY registration number:INPLASY202150071.     

上颌中切牙种植进入鼻腭管的研究进展

上颌中切牙缺失后常伴随唇侧骨壁吸收,造成唇腭向牙槽嵴宽度减少,出于前牙区美学修复的考量,种植位点常偏腭侧。鼻腭管(nasopalatine canal, NPC)在解剖位置上紧邻上颌中切牙种植位点,造成术中植体可能进入NPC,伴随腭部感觉异常和（或）种植体非骨结合,甚至发生种植体脱落。NPC穿孔作为上颌中切牙种植手术的并发症之一,不仅降低种植术成功率,还引起患者负面心理情绪。故本文就上颌美学区种植NPC穿孔的发生率、影响NPC穿孔相关因素、临床检查及诊断、预防措施及临床治疗方法等作一综述,为美学区种植避免NPC穿孔提供理论参考。     

儿童严重脓毒症免疫功能的变化

目的 探讨儿童严重脓毒症体液免疫、淋巴细胞亚群和NK细胞水平变化,与病情严重程度及预后的关系.方法 2013年3月至2017年2月,上海交通大学附属儿童医院重症医学科收治严重脓毒症患儿共224例,其中82例于入PICU 24h内和治疗7d后至少2次进行体液免疫(IgG、IgM、IgA)、细胞免疫[淋巴细胞亚群CD3+、CD4+、CD8+、CD19+]和NK细胞(CD16+56+)测定,比较存活组(59例)与死亡组(23例)、不同器官功能状态患儿(累及出现器官功能障碍个数>3个共36例,2~3个共30例,1个共16例)的免疫功能变化.同期体检儿童15例作为正常对照组.结果 (1)严重脓毒症患儿入PICU时血NK细胞明显低于正常,治疗7 d后存活组NK细胞数量升高[(3.7±1.9)% 比(11.5±1.9)%,P<0.05];严重脓毒症组与正常对照组IgG、IgM、IgA比较差异无统计学意义(均P>0.05),而淋巴细胞亚群中CD3+、CD4+、CD8+细胞比较差异有统计学意义[(62.8±8.5)% 比(70.9±2.3)%、(33.3±7.0)% 比(39.8±1.8)%、(22.6±2.8)% 比(34.8±15.6)%,均P<0.05].(2)淋巴细胞亚群CD3+、CD4+及NK细胞比例随患儿儿童危重病例评分降低、第三代儿童死亡危险评分增高及器官功能障碍数目增多,呈明显下降趋势,差异有统计学意义(P<0.05),血清IgG、IgM、IgA及CD19+细胞变化差异无统计学意义(P>0.05).(3)死亡组患儿在入院24h内NK细胞及CD3+、CD4+细胞水平明显低于存活组[(1.5±0.5)% 比(4.7±1.4)%,(55.1±5.0)%比(66.4±7.4)%,(29.7±5.2)%比(35.0±7.2),均P<0.05].结论 未发现免疫球蛋白水平与严重脓毒症患儿病情严重程度有相关性;NK细胞及CD3+、CD4+淋巴细胞降低是脓毒症病情加重的标志,可作为评估严重脓毒症患儿预后的参考指标.     

儿童原发性膀胱毛细血管扩张症1 例报告并文献复习

目的分析原发性膀胱毛细血管扩张症的诊断思路。方法回顾1例原发性膀胱毛细血管扩张症患儿的临床资料。结果患儿,女,9岁。近3岁时无明显诱因出现肉眼血尿,以后多次呼吸道感染后诱发的间断肉眼血尿,血凝块,持续性镜下血尿,曾伴失血性休克1次。尿常规蛋白+~++,红细胞满视野;24 h尿蛋白定量0.96 g;腹部、泌尿系超声、泌尿系增强CT扫描未见异常;肾动脉造影未见动静脉畸形或瘘;膀胱镜检查提示毛细血管扩张症。患儿无相关家族史,无其他部位毛细血管扩张。遗传性毛细血管扩张症和共济失调-毛细血管扩张症相关基因突变分析未见异常。结论儿童原发性膀胱毛细血管扩张症临床较为罕见,对于表现为早发、长期、间断肉眼血尿伴血凝块,特别有失血性休克者,应首先考虑血管因素病变可能,常规行泌尿系统各种影像学,包括血管造影检查,必要时膀胱镜检查。     

止痛消肿散对兔膝骨关节模型血清中IL-1β、TNF-α含量的影响

目的:观察外治方止痛消肿散对兔膝骨关节炎模型血清中IL-1β、TNF-α含量的影响,明确药物改善兔膝骨关节炎功能障碍的作用机制。方法:将36只兔随机分为6组,除正常对照组外,其余各组均采用膝关节制动法建立兔膝骨关节炎的动物模型,以止痛消肿散外洗兔膝关节2周,处死动物,取血液分离血清,应用酶联免疫吸附技术(ELSIA)检测各组动物血清中IL-1β、TNF-α含量。结果:与模型组比较,正常对照组IL-1β、TNF-α含量具有显著性差异(P<0.01);与正常对照组比较,各药物组无差异(P>0.05);模型组与其他各治疗组IL-1β、TNF-α水平有不同程度的下降(P<0.05);止痛消肿散低、中、高组与骨友灵搽剂组比较,无差异(P>0.05);止痛消肿散低、中、高组之间比较,其中IL-1β含量无差异(P>0.05),TNF-α含量有显著性差异(P<0.05)。结论:止痛消肿散能够降低兔膝骨关节模型兔血清中IL-1β、TNF-α的含量,表明药物具有减轻骨关节炎炎性细胞因子的作用,为临床进一步推广应用及药物研发提供了客观依据。     

188Re-β射线诱导肝癌细胞凋亡与细胞周期阻断

目的：探讨放射性素^188Re-β射线内照射对人肝癌细胞HCC的细胞周期阻断及诱导凋亡的作用,方法：通过MTT实验,形态学观察,琼脂糖凝胶电泳和流式细胞术对核素诱导的HCC细胞进行了检测和观察,结果：^188Re导致的HCC细胞死亡具有典型的细胞凋亡形态学和生化特征,流式细胞术定量显示各期细胞数发生改变,且凋亡率和剂量呈依赖性,结论：^188Re-β射线低剂量和高剂量对HCC细胞周期的影响不同,低剂量主要使C0／G1期阻滞,较高剂量则导致G1阻滞减轻,S期和G2／M期细胞数增多。     

聚合物／金属复合物合成超导化合物的研究

使用聚合物/金属复合物(简称PMC)前体这一新型工艺,制备出单相态的超导化合物Y_1Ba_Cu_3O_x其工艺的累积时间比同类无机盐溶液法缩短60%,温度降低50℃～100℃,所得样品起始转变温度T_(c,始)=93.63K,零电阻温度T_(c零)=90.09K,转变宽度ΔT=0.5K。     

吞咽功能训练对食管癌术后吞咽功能障碍患者吞咽功能及生活质量的影响

目的 探究吞咽功能训练对食管癌术后吞咽功能障碍患者吞咽功能及生活质量的影响.方法 将100例食管癌患者按干预方式不同分为观察组及对照组,每组50例.对照组接受常规干预,观察组接受常规干预+吞咽功能训练.比较两组患者干预前(术后第1天)、干预后(出院前1天)的标准吞咽功能评定量表(SSA)评分,术前、术后3天、术后7天时体重、血清白蛋白(ALB)和血红蛋白(Hb)水平以及欧洲癌症治疗研究组织生命质量测定量表(EORTC QLQ-C30)评分.结果 干预前,两组患者SSA评分,体重、ALB、Hb水平,QLQ-C30评分比较,差异均无统计学意义(P﹥0.05).干预后,两组患者SSA评分均明显降低,且观察组SSA评分明显低于对照组,差异均有统计学意义(P﹤0.01).术后3天,观察组患者ALB、Hb水平均高于对照组,差异均有统计学意义(P﹤0.05);术后7天,观察组患者体重、ALB、Hb水平均高于对照组,差异均有统计学意义(P﹤0.05).干预后,两组患者QLQ-C30评分中躯体功能、认知功能、角色功能、情绪功能、社会功能评分及总分均升高,且观察组均高于对照组,差异均有统计学意义(P﹤0.05).结论 吞咽功能训练可有效帮助食管癌术后吞咽功能障碍患者吞咽功能恢复,改善营养状况,提高其生活质量.     

Enhanced detection of toxicity in wastewater using a 2D smooth anode based microbial fuel cell toxicity sensor

As the biological recognition element of microbial fuel cell (MFC) toxicity “shock” sensors, the electrode biofilm is perceived to be the crucial issue that determines the sensing performance. A carbon felt and indium tin oxide (ITO) film anode were utilized to examine the effects of anodic biofilm microstructure on MFC toxicity sensor performance, with Pb²⁺ as the target toxicant. The carbon felt anode based MFC (CF-MFC) established a linear relationship of Pb²⁺ concentration (C_Pb²⁺) vs. voltage inhibition ratio (IR_2h) at a C_Pb²⁺ range of 0.1 mg L⁻¹ to 1.2 mg L⁻¹. The highest IR_2h was only 38% for CF-MFC. An ITO anode based MFC (ITO-MFC) also revealed a linear relationship between C_Pb²⁺ and IR_2h at C_Pb²⁺ of 0.1 mg L⁻¹ to 1.5 mg L⁻¹ but better sensing sensitivity compared with the CF-MFC. The IR_2h of ITO-MFC gradually approached 100% as C_Pb²⁺ further increased. The enhanced sensing sensitivity for the ITO anode possibly originated from the thin biofilm that resulted in the efficient exposure of exoelectrogens to Pb²⁺. The employment of 2D conductive metal oxide with a smooth surface as the anode was able to increase the MFC sensing reliability in real wastewater.

The thin biofilm on the anode surface is more conducive to the diffusion of toxins thus has better sensing performance.