全文获取类型
收费全文 | 295486篇 |
免费 | 8491篇 |
国内免费 | 1088篇 |
专业分类
耳鼻咽喉 | 3024篇 |
儿科学 | 8413篇 |
妇产科学 | 4823篇 |
基础医学 | 36031篇 |
口腔科学 | 4584篇 |
临床医学 | 23684篇 |
内科学 | 52319篇 |
皮肤病学 | 4586篇 |
神经病学 | 26292篇 |
特种医学 | 15743篇 |
外科学 | 44524篇 |
综合类 | 2813篇 |
现状与发展 | 3篇 |
一般理论 | 27篇 |
预防医学 | 24357篇 |
眼科学 | 5791篇 |
药学 | 19942篇 |
中国医学 | 2076篇 |
肿瘤学 | 26033篇 |
出版年
2023年 | 663篇 |
2022年 | 2037篇 |
2021年 | 4392篇 |
2020年 | 2106篇 |
2019年 | 2953篇 |
2018年 | 25043篇 |
2017年 | 19886篇 |
2016年 | 22829篇 |
2015年 | 6259篇 |
2014年 | 7181篇 |
2013年 | 8194篇 |
2012年 | 17895篇 |
2011年 | 31160篇 |
2010年 | 24451篇 |
2009年 | 16405篇 |
2008年 | 26487篇 |
2007年 | 28295篇 |
2006年 | 6907篇 |
2005年 | 8040篇 |
2004年 | 8469篇 |
2003年 | 8741篇 |
2002年 | 6292篇 |
2001年 | 3280篇 |
2000年 | 3177篇 |
1999年 | 2285篇 |
1998年 | 1093篇 |
1997年 | 861篇 |
1996年 | 589篇 |
1995年 | 544篇 |
1994年 | 480篇 |
1993年 | 386篇 |
1992年 | 780篇 |
1991年 | 776篇 |
1990年 | 758篇 |
1989年 | 628篇 |
1988年 | 514篇 |
1987年 | 503篇 |
1986年 | 353篇 |
1985年 | 396篇 |
1984年 | 279篇 |
1983年 | 211篇 |
1982年 | 156篇 |
1981年 | 168篇 |
1980年 | 167篇 |
1979年 | 224篇 |
1978年 | 170篇 |
1976年 | 140篇 |
1975年 | 125篇 |
1974年 | 158篇 |
1973年 | 120篇 |
排序方式: 共有10000条查询结果,搜索用时 375 毫秒
981.
Antonio Fea Andrea Grosso Marilena Rabbione Federico Grignolo 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(2):315-317
Background Optic disc anomalies are frequently associated with Alagille syndrome. We report here the first case of a patient with Alagille
syndrome combined with optic pit and serous macular detachment.
Methods A male patient with Alagille syndrome was referred from the pediatric hepatology department for investigation of visual loss
in the right eye. Anterior segment examination showed evidence of posterior embryotoxon, confirmed by gonioscopic evaluation.
Dilated fundus examination revealed serous macular detachment and optic pit.
Results OCT 3 scans confirmed the clinical findings.
Conclusions Optic pit is uncommon and should prompt a search for genetic disorders or development abnormalities. The association between
the two syndromes in this patient might be due to failure of correct neuroectodermal development, for which a common genetic
pathway is likely. 相似文献
982.
Background
January 1, 2002, copayment for outpatient female sterilization in Norwegian public hospitals increased from 33 euros to 750 euros after a revision of the health care system. The aim of the present study was to investigate the effect of the new copayment system on female sterilization epidemiology. 相似文献983.
Peter Christian Ruokonen Thomas Schwenteck Jörg Draeger 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(9):1259-1265
BACKGROUND: Two new tonometers have been introduced that are based on the impedance principle. Both the TGDc-01 (transpalpebral measurement) and the iCare (corneal measurement) do not require corneal anaesthesia. The present work presents an evaluation of both devices. METHODS: Comparative measurements using one of the new tonometers and applanation tonometry were performed by one investigator according to the international standard for ocular tonometer (ISO 8612). Measurements were performed on 445 eyes without corneal pathology from 243 patients. Six measurements were performed for iCare and 3 for TGDc, immediately followed by 3 applanation tonometry measurements. RESULTS: The correlation coefficient with respect to applanation tonometry was 0.81 for TGDc and 0.95 for iCare. TGDc-01 measurements showed an average deviation of 3.1 +/- 2.6 mmHg to those of Perkins applanation tonometry. The maximum difference was 28.7 mmHg below and 9.8 mmHg above the results of applanation tonometry. iCare showed an average deviation of 2.5 +/- 1.1 mmHg to Goldmann tonometry. The maximum difference was 14.5 mmHg below and 9.8 mmHg above. CONCLUSIONS: The results of both new tonometers showed a good correlation with the reference applanation tonometric methods, but the strict requirements of ISO 8612 are not fulfilled by either tonometer at present. Additionally, transpalpebral measurements with the TGDc-01 showed unacceptably high variability. 相似文献
984.
985.
Claudia KY Lai 《BMC nursing》2007,6(1):5
Background
To date, the literature has provided an abundance of evidence on the adverse outcomes of restraint use on patients. Reportedly, nurses are often the personnel who initiate restraint use and attribute its use to ensuring the safety of the restrained and the others. A clinical trial using staff education and administrative input as the key components of a restraint reduction program was conducted in a rehabilitation setting to examine whether there were any significant differences in the prevalence of restraint use pre- and post-intervention. Subsequent to the implementation of the intervention program, focus group interviews were conducted to determine the perspective of the nursing staff on the use of restraints and their opinions of appropriate means to reduce their use. 相似文献986.
987.
988.
989.
Katherine Wiegmann Shylaja Muthyala Duk Hwan Kim Barry G. W. Arnason Ewa Chelmicka-Schorr 《Journal of neuroimmunology》1995,56(2)
Chronic/relapsing experimental allergic encephalomyelitis (CREAE) serves as an animal model for relapsing/remitting multiple sclerosis. Treatment with the β-adrenergic agonist isoproterenol or the β2-adrenergic agonist terbutaline significantly suppressed both the first acute attack and the number of relapses in CREAE Lewis rats. The number of relapses was decreased even when treatment with β-adrenergic agonist was started after the onset of the first acute attack of CREAE. β-adrenergic receptor number was increased significantly on splenocytes from CREAE rats as compared to healthy controls or CFA-injected rats. Terbutaline treatment of CREAE rats lowered the splenocyte receptor number to normal values. 相似文献
990.
D. G. Kim C.-Y. Kim S. H. Paek D. S. Lee J.-K. Chung H.-W. Jung B.-K. Cho 《Acta neurochirurgica》1998,140(7):665-674
Summary
Background To determine its roles in the diagnosis and the systemic evaluation of metastatic brain tumours, whole-body positron emission
tomography (PET) using [18F]FDG was performed in 20 consecutive patients.
Methods
All patients were thought to be suffering or needing to be differentiated from metastatic brain tumours. Nine patients had
multiple brain lesions; six were older and showed a rim-enhancing lesion with surrounding oedema; seven had homogeneously
enhancing periventricular lesion(s) on computed tomography (CT) and/or magnetic resonance (MR) imaging, thought to be central
nervous system lymphomas. Two patients had skull mass(es) and two patients had a solid mass suspected to be, respectively,
a haemorrhagic metastasis and a metastatic malignant melanoma. All of them received whole-body [18F]FDG PET and conventional systemic work-up for metastasis in order to compare the results of the two methods.
Results
Metastatic brain tumours were diagnosed on whole-body [18F]FDG PET in eleven patients who had extracranial and intracranial hypermetabolic lesions. In nine of these, a conventional
work-up also detected primary lesions which on whole-body [18F]FDG PET were seen to be hypermetabolic foci. Systemic lymph node metastases were detected by whole-body [18F]FDG PET only in two patients and histological diagnosis was possible by biopsy of lymph nodes rather than of brain lesions.
In the remaining nine patients who had only intracranial hypermetabolic foci, histological diagnosis was made by craniotomy
or stereotactic biopsy. It was confirmed that seven of nine patients were suffering from a primary brain tumour and two from
metastatic carcinoma. None of the nine showed evidence of systemic cancer on conventional work-up. Histological diagnoses
of the primary brain tumours were four cases of primary central nervous system lymphoma and one each of multifocal glioblastoma,
Ewing's sarcoma, and cavernous angioma.
Patients felt no discomfort during the whole-body [18F]FDG PET procedure and there were no complications. The false negative rate in [18F]FDG PET and in conventional work-up was 15.4% and 30.7% respectively. There were no false positives on either [18F]FDG PET or conventional work-up.
Conclusion
It is suggested that whole-body [18F]FDG PET is a safe, reliable, and convenient method for the diagnosis and systemic evaluation of patients thought to be suffering
or needing to be differentiated from a metastatic brain tumour. 相似文献