Characteristics of different isolates of Schistosoma japonicum from China in the final hosts

The present paper deals with the susceptibility of common laboratory animals, such as mouse, rat, hamster, jird, rabbit and rhesus monkey, to infection with different isolates of Schistosoma japonicum in the mainland of China under laboratory conditions. With the exception of the rat, all the animals under study were permissive hosts for different isolates though their worm recovery rates varied. The mean body length of pair-worms of the Yunnan isolate was considerably smaller than that of the Anhui, Hubei, Guangxi and Sichuan isolates, and the percentage of male specimens with 7 testes in the Yunnan isolate was also significantly less than that in the other 4 isolates. Judging from the egg index (width/length x 100), the eggs of the Sichuan isolate were broad and short in shape, giving a high index; those of Guangxi and Hubei isolates were oblong, giving the lowest index; the other two isolates from Yunnan and Anhui, lay between these two extremes. The mean prepatent periods were longer in mice, hamsters and rhesus monkeys infected with Yunnan and Guangxi isolates, than those with Sichuan isolate. A dendrogram of the 5 isolates of S. japonicum was constructed on the basis of similarity coefficients by means of fuzzy cluster analysis on the biological characters mentioned above. Our results provide evidence of the existence of different strains of S. japonicum in the mainland of China as shown by comparative studies of their characteristics in the final hosts.     

绥芬河公路口岸附近地区鼠类EHF IgG抗体调查报告

目的 了解绥芬河公路口岸附近EHF亚在鼠类中的流行动态。方法 对鼠类进行EHF IgG抗体监测。结果 检测142只、5种鼠类的血样，检出EHF IgG抗体阳性29例，阳性率为20．42％。其中黑线姬鼠的移抗体IgG抗体阳性率较高，为30．95％。结论 EHF宿主是属于多源性动物宿主，而黑线姬鼠是主要贮存宿主和传染源，提示我们要注意防鼠、灭鼠。     

高血压病人药物治疗期间动态血压变化

目的评价高血压病人药物治疗期间２４ｈ动态血压变化。方法２６例住院的高血压病人经药物治疗４周连续３ｄ随测血压，血压正常后进入本研究。治疗前后进行２４ｈ动态血压监测。结果患者随测血压（８～９ＡＭ，３～４ＰＭ）血压恢复到正常水平，但动态血压显示在一段时间内（６～８ＡＭ，６～１１ＰＭ）平均收缩和舒张压仍明显高于正常人平均水平（Ｐ＜０．０１），而该时间段易被临床医生忽视。结论随测血压不能实际全面反映高血压病人药物治疗的疗效，２４ｈ动态血压的监测可以正确评价高血压病人药物治疗的效果并根据高血压分布的时间来调整降压药的种类和剂量。     

肺炎性假瘤(附52例报告)

目的：分析肺炎性假瘤的临床病理特点，并探讨其诊断问题，方法：回顾性分析52例肺炎性假瘤的临床病理资料。结果：男女发病比为2．25：1，平均年龄50．6岁，平均病程10．8个月，临床主要表现为咳嗽或咳痰，痰中带血或咯血，胸痛或背痛；影像检查见肿块位于肺周边部，单发，圆形或类圆形，病理检查肿块最大平均直径为3．9cm，见于各肺多于左肺，双上肺多于双下肺，44．2％同侧肺门淋巴结因反应性增生而肿大；经系统抗炎，抗结核治疗，肺肿块影均无改变，手术切除可治愈，结论：肺炎性假瘤有其特点，可与肺癌、肺结核、肺炎相区别；确诊仍需病理活检；CT或超声引导经皮活检值得推广，并应重视电视胸腔腔镜在诊治中的作用。     

高压氧治疗尺桡神经损伤疗效观察

应用高压氧治疗尺桡神经损伤修复术后１１例，与同期单纯手术修复１４例相比，优良率明显提高，二组间有显著差异。Ｐ＜０．０５，提示高压氧对尺桡神经损伤的修复有促进作用     

Rapid hypertensinogenic effect of lead: studies in the spontaneously hypertensive rat.

Chronic lead exposure may cause hypertension in normotensive rats. This hypertensinogenic effect has been attributed to perturbations in the renin-angiotensin axis, the contractile response of the vascular smooth muscle, or the intracellular Ca2+ homeostasis as a consequence of the inhibition of Na(+)-K(+)-ATPase activity. In this study we examined the short-term effect of lead exposure on blood pressure, plasma renin activity, vascular contractility, and renal Na(+)-K(+)-ATPase activity and abundance in the spontaneously hypertensive rat. Our data indicate that modest lead exposure caused blood pressure elevation within two weeks in this rat strain that is genetically susceptible to the development of hypertension. This rapid blood pressure-elevating effect did not appear to depend on the mechanisms described in hypertension associated with more chronic lead exposure listed above. This acute model provides an additional approach to the study of lead-induced hypertension.     

锰超氧化物岐化酶模型配合物的研究

为探索天然超氧化物岐化酶（ＳＯＤ）岐化超氧离子的机理，及用于临床的可能性，我们合成了乳酸、柠檬酸和酒石酸的锰（Ⅱ）配合物作为Ｍｎ－ＳＯＤ的模拟物，用光照法测定了它们的活性，得到了有意义的结果：锰配合物作为Ｍｎ－ＳＯＤ的模拟物，有肯定的活性，其中以乳酸锰配合物活性最高。     

The clinical significance of red cell immune adherence function in patients with pulmonary tuberculosis and silicotuberculosis]

In our study, we observed that (1) High RCIA were discovered in these two groups. (2) In the group of pulmonary tuberculosis, the C3b receptor activities remained no change after antituberculous therapy, but the amounts of immune complexes bearing on RBC decreased. In the patients with the high RCIA, CIC was discharged rapidly and the lesions of tissue produced by CIC were prevented. In the patients with silicotuberculosis, both silica and tuberculous bacilli may act as immune adjuvant and enhance the hypersensitivity. So the C3b receptor activities were higher in silicotuberculosis patients.     

Comparative Study on the Immunogenicity between Recombinant MS-Sj26GST Vaccine and Recombinant BCG-Sj26GST Vaccine in Schistosoma japonicum

TuberculosisandSchistosomiasisarethemajorcontagiousdiseaseswhicharethemostdangeroustothepeople’shealth Inordertogetridofthem ,wemustlookforamoreusefulvaccine Bythetech niquesofmolecularbiology ,2 6 0 0 0DaGlutathionStransferase (GST) genewasclonedintotheE coli MycobacteriumtransferringandexpressionvectorpBCG 2 0 0 0totransformittoMycobacteriumsmeg matismc2 15 5 (MS)andBCGseparatelyinordertoconstructrMS Sj2 6GSTvaccineandrBCG Sj2 6GSTvaccine Inthisstudy ,theBALB/cmicewereimmu niz…     

不同浓度的金属硫蛋白对离体豚鼠乳头肌缺氧、复氧电生理特性的影响

为探讨金属硫蛋白（MT）对豚鼠乳头肌缺血再灌注损伤所致心律失常的影响，利用标准玻璃微电极技术，采用缺氧及复氧豚鼠乳头肌模型，模拟体内缺血再灌注损伤，观察不同浓度MT对豚鼠乳头肌电生理特性的影响。结果显示低浓度的MT（0．002mmol／L）对正常及缺氧和复氧豚鼠乳头肌的动作电位（AP）有关参数及自律性均无影响；中等浓度的MT（0．02mmol／L）仅使正常乳头肌的AP复极达50％时程（APD50）缩短24％（P＜0．05），但使缺氧乳头肌的AP复极达20％时程（APD20）、APD50和AP复极达90％时程（APD90）分别缩短68％、56％和43％（P均＜0．01），并使静息电位（RP）、AP幅值（APA）和0相最大上升速率（Vmax）分别增加30％、30％和45％（P均＜0．01）；高浓度的MT（0．1mmol／L）使正常豚鼠乳头肌的APD20、APD50和APD90分别缩短57％、54％和50％（P均＜0．01），并且RP、APA及Vmax分别下降22％（P＜0．05）、28％（P＜0．01）和29％（P＜0．05），而使缺氧豚鼠乳头肌的APD20、APD50和APD90分别延长92％、78％和50％（P均＜0．01），对RP、APA及Vmax无明显影响。在复氧期间，0．02mmol／L的MT可使自律性的发生率从77．8％降至55．6％（P＜0．05）；而0．1mmol／L的MT则使自律性的发生率从77.8％降至22．2％（P