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91.
Multiclefted nuclei. A helpful feature for identification of intermediate trophoblastic cells in uterine curetting specimens. 总被引:1,自引:0,他引:1
Intermediate trophoblast is a distinct form of trophoblast, the presence of which in uterine curettings is considered a reliable indicator of intrauterine pregnancy even in the absence of chorionic villi. However, the appearance of intermediate trophoblastic cells have not been described in sufficiently specific terms to permit their reliable identification, and distinction from decidual cells can be difficult. We have noticed for some time that the intermediate trophoblastic cells often show multiple deep clefts in the nuclei, and the present study was performed to address the issue of whether this nuclear feature is reliable for their identification. We reviewed 242 uterine curettings of intrauterine pregnancy, documented by the presence of chorionic villi, and were able to find a distinct population of cells with large, hyperchromatic, multiclefted nuclei scattered in the decidua in 88% of the cases. In most instances, these cells produced a characteristic variegated pattern that was readily recognizable at low magnification. Positive immunostaining for cytokeratin (CAM 5.2) in these isolated cells within the decidua confirmed their trophoblastic nature. In contrast, multiclefted nuclei were absent in the 51 negative control cases, which included decidualized endocervical polyps (40 cases), uterine curettings from patients with tubal pregnancy (10 cases), and endometriosis with decidual change (one case). We conclude that intermediate trophoblastic cells can usually be reliably identified in curettings of intrauterine pregnancy by their characteristic nuclear multiclefting. 相似文献
92.
The serum apolipoprotein A- I (apo A-I) Concentrations in 39 patients with posthepatitis cirrhosis were reported to be 0.87±0.27 g/L lower than that of controls 1.15±0.14 g/L P<0.01. The, decrease of apo. A-I was correlated with the severityof impaired liver function. Apo A- I concentrations in serum correlated positively with decrease of serum albumin (r=0.503 P< 0.01) and negatively with serum bilirubin increase (r=- 0.508 P <0.01) . The data indicate that decreasing of apo A- I concentration may be regarded as one of the reliable indices reflecting the degree of liver function impairment. 相似文献
93.
本文报道用550型全自动生化分析仪,以速率法测定尿NAG活性及本室尿NAG活性的正常参考范围;并对可能影响尿NAG活性的尿PH,尿素浓度等进行了干扰试验及分析。 相似文献
94.
本文在国内首次报告了念珠状链杆菌在清洁级C57BL/6J小鼠群中的自然感染,并从临床、病理解剖、病原学及流行病学方面进行了较为详细的观察,在受检的14例发病动物中,颈部淋巴结肿大、化脓占71.4%,皮下、肺门淋巴结脓肿分别占50.0%和21.4%,多发性关节炎(包括趾、跗关节)占21.4%,子宫积脓占7.1%,从所有病灶及部分动物的血液、脾、肝、肺、肾均分离到了单一的细菌。该菌在小鼠成功地进行了急性感染实验,受感染动物出现了典型的念珠状链杆菌病的临床及病理特征,即败血症、关节炎、淤血、水肿、紫绀、结膜炎等。所分离的致病菌在病原学上也完全符合念珠状链杆菌的病原学特征。在饲养环境上与发病鼠群有密切关系的其它4个品系小鼠群,即615、BALB/c、CBA、KM,均未波感染,证明在对该菌的易感性方面存在品系差异。 相似文献
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97.
作者曾经体外实验证明,均聚寡脱氧胞嘧啶核苷酸片段(dC14)有抗病毒活性,现继续研究其在体内的作用。不给dC14的对照组小鼠,接种腹水瘤细胞后:100%发病和死亡,潜伏期为6d,存活期11d;给每只小鼠dC14 1.3~3.2 mg,发病率和死亡率降低至20%,疾病潜伏期和存活期推迟。在未经dC14处理的种瘤细胞和淋巴组织与经处理的淋巴组织中,多聚酶链反应(PCR)法都检测到病毒核酸,而正常小鼠中则无此种病毒核酸顺序。研究结果提示,dC14对小鼠SRS腹水瘤的发病和生长有抑制作用。此种抑制作用可能是通过抑制病毒基因的表达来实现的。 相似文献
98.
Twenty-seven in-patients with obstetric DIC in our hospital from Jan. 1971 to Dec. 1990 were analysed retrospectively. The incidence was 0.12% in the first decade and 0.02%, in the second, showing a difference of significance between them. The most common predisposing factors included amniotic fluid embolism, abruptio placenta and hemorrhagic shock. Bleeding from multi-organs in various extent and coagulation disorders occurred in all those 27 cases. [Besides anti-shock treatment, heparin was employed together with fibrinogen in 4 postpartum and 1 antepartum DIC patients, fibrinogen alone in 8 cases, and hysterectomy in 11 cases. 17 patients were saved and 9 died. It is important that early diagnosis and much attention paid to clinical characteristics together with serial laboratory tests. Key management should include prompt treatment and eradication of predisposing factors. Quick decision spite of to terminate the pregnancy and even hysterectomy should be done in some risks. 相似文献
99.
100.
单用达那唑(DNZ)治疗19例慢性再生障碍性贫血(CAA)病人。结果表明,基本治愈1例,缓解5例,明显进步7例,有效者共13例,总有效率为68.4%,初治者5/7例有效,有效率为71.4%;复治者8/12例有效,有效率为66.7%。治疗后与治疗前比较,血红蛋白、白细胞、血小板和网织红细胞均明显升高(P<0.001);骨髓红系、粒系及巨核细胞明显增高(P<0.05);T辅助细胞(CD4)明显增加、T抑制细胞(CD8)明显降低,CD4/CD8比值明显升高(P<0.05)。并结合文献对DNZ的作用原理进行讨论。 相似文献