NSE与视频脑电图在儿童热性惊厥的相关性研究

Objective: To evaluate the diagnostic value of serum neuron specific enolase and Video EEG inFebrile Convulsion of childen. Method:Serum NSE was detected by RIA on the first day and the seventh day afterseizure in 40 children with simple febrile convulsion and 18 with complex febrile convulsion. Video EEG was per-formed at 1st, 7th and 30th day in all the patients. Results: There were significant differences between NSE levels at24th hour and on 7th day after convulsion (P<0.01). NSE concentrations in patients with SFC and CFC were also     

结肠灌洗法对直肠癌患者术后排便功能的影响

Background:Defecation of patients with rectal carcinoma after operation cannot be controlled freely,which brings patients many mental burdens.Cocolyster operation can improve obviously the symptom.     

哈尔滨市社区卫生服务需求、利用及影响因素分析

目的：为了了解哈尔滨市居民对社区卫生服务的需求、利用情况以及影响因素。方法：采用分层整群抽样，对哈尔滨市2000名居民进行了入户调查。结果：被调查居民的两周患病率为34．3％，两周就诊率为27．7％，其未就诊率为30．0％。影响人们对卫生服务利用的因素有收入、患病次数、健康状况等因素。结论：社区卫生服务应不断加强和完善，从而真正成为实现卫生目标的有效途径。     

230例打鼾患者多导睡眠图分析

目的　探讨多导睡眠图 (PSG)对睡眠呼吸暂停综合征 (SAS)的诊断价值及睡眠呼吸暂停综合征 (SAS)对睡眠结构、血氧、心血管系统的影响。方法　对 2 30例打鼾患者进行多导睡眠图监测。结果　 2 30例诊断SAS10 8例 (46 9% ) ,单纯鼾症 (SS) 12 2例 ,SAS与SS组两组相比在睡眠结构、呼吸紊乱、血氧、心血管系统变化等差异有显著性。结论　PSG是诊断SAS、判定病情程度、指导治疗的一种良好方法     

A novel DRB1*09 allelic sequence in the Jing ethnic minority of China.

A new DRB1 allele, DRB1*0902, has been identified in an individual of the Jing ethnic minority. Its sequence was confirmed by sequencing of PCR products and clones. This allele differed by three nucleotides from DRB1*09012 at positions 157, 161 and 166, and resulted in amino acid motif substitution from VAES to DAEY.     

黑质内注射FeCl3对大鼠纹状体多巴胺释放量及含量的影响

①目的探讨黑质(SN)内注射不同剂量的FeCl3对大鼠纹状体(CPu)多巴胺(DA)释放量和含量的影响.②方法实验用SD大鼠32只,分成4组6只大鼠为正常对照组;9只大鼠左侧SN内注射 FeCl3溶液10 μg(Ⅰ组);8只大鼠左侧SN内注射FeCl3溶液20 μg(Ⅱ组);9只大鼠左侧SN内注射FeCl3溶液40 μg(Ⅲ组),3周后采用快速周期伏安法(FCV)监测纹状体D A的释放量,高效液相色谱法(HPLC)检测纹状体DA含量.③结果在FeCl3单侧损毁大鼠中,损毁侧CPu DA释放量的减少和DA含量的降低与注射FeCl3剂量之间有明显剂量依赖关系(F=93.78,164.51,q=3.50～29.79,P<0.05).Ⅲ组损毁侧CP u DA的更新率[以(DOPAC+HVA)/DA表示]明显加快,与其他组比较差异有显著性(F=13 6.22,q=22.32～22.72,P<0.05);而Ⅰ,Ⅱ组变化较小,与正常大鼠相比差别无统计学意义 (q=0.25,2.04,P>0.05).④结论黑质内Fe3+含量升高可使CPu内DA释放量和含量均降低,铁含量高可能参与帕金森病的病理改变.     

善宁治疗顽固性大咯血疗效观察

目的 评价善宁对顽固性大咯血的疗效。方法 将55例传统药物抢救无效或有禁忌的大咯血分为治疗组（善宁）与对照组（立止血组），观察24—72h的止血效果。结果 治疗组总有效率为92％，对照组为70％，两组比较有显著差异p〈0．05（x^2=4．125）。结论 善宁治疗大咯血疗效显著，使用安全，不良反应少，值得临床推广应用。     

In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats

The in vivo action of insulin-like growth factor-I on bone metabolism has been studied using a new model. Insulin-like growth factor-I (IGF-I) was continuously infused into the arterial supply of the right hindlimb of ambulatory rats for up to 14 days and the effects on cortical and trabecular bone formation and the number of osteoclasts were determined by histomorphometric techniques. The contralateral limb acted as an internal control. IGF-I infusion significantly increased cortical bone formation (p less than 0.01). Trabecular bone was increased 22% (p = 0.07), but the infusion was only for seven days. These effects of IGF-I were age dependent, being absent in young, rapidly growing animals, but present at least until one year of age. IGF-I appears to be a purely anabolic hormone for bone formation, since it significantly stimulates osteoblasts and decreases the number of osteoclasts. Thus, although IGF-I mediates the growth-promoting effect of growth hormone, it does not mediate growth hormone's action on bone resorption.     

高效液相色谱法测定右旋儿茶素血浆浓度及药代动力学参数

本文建立了体液中右旋儿茶素的RP-HPLC测定方法。采用C_(18)键合相硅胶为填料的固相提取柱进行样品预处理,右旋儿茶素的提取回收率为79.8%.应用二极管阵列检测器对色谱峰纯度进行鉴定。该法精密度好,方法回收率近100%,日内、日间的变异系数为2.4～5.6%,血浓69.6～1160 ng/ml范围内呈线性关系,r=0.9993。家兔静注右旋儿茶素18mg/kg,其药代动力学过程符合二室模型,分布相半衰期为0.129 h,消除相半衰期为1.19h。