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101.
Spear HJ 《Public health nursing (Boston, Mass.)》2004,21(4):338-346
Results not discussed in a previously published qualitative study (Spear, 2001) are presented in this article. Analysis of the personal narratives of eight pregnant adolescents who attended an alternative school for pregnant teens yielded the following categories: decision making, contraceptive behavior and sexual attitudes, and future expectations. The findings revealed that decisions regarding pregnancy were made with little deliberation and some participants implied that pregnancy was planned. Although knowledgeable about how to prevent pregnancy, participants did not consistently practice contraception and their sexual experiences were marked by indifference and lacked intimacy. Future expectations consistently included support from the fathers of their unborn children. Implications for nursing practice and further research are discussed. 相似文献
102.
Autonomy and adolescence: a concept analysis 总被引:3,自引:0,他引:3
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Spear HJ 《Nursing forum》2004,39(4):34-35
Nursing is multidimensional, interactive, interdisciplinary, and complex. Almost anything that can be said about nursing can be said another way. Some things worth being said and heard will not follow the norms of journal presentation. A forum accommodates the emerging voice, the new format, the innovative approach. Nursing Forum , in an effort to honor the independent voice in nursing, presents here the voice who elects to enter the dialogue, but who does so "in another way." 相似文献
106.
Nevo I Sagi-Assif O Meshel T Geminder H Goldberg-Bittman L Ben-Menachem S Shalmon B Goldberg I Ben-Baruch A Witz IP 《Immunology letters》2004,92(1-2):163-169
In previous studies, we demonstrated that human neuroblastoma cells are equipped with the machinery to direct their homing to bone marrow. These tumor cells express the CXCR4 receptor for the bone marrow stroma-derived chemokine CXCL12 (SDF-1) and secrete the CXCL12 ligand. The present study was undertaken to explore possible differences in gene-expression patterns between neuroblastoma variants that over-express CXCR4 (designated STH cells) and those which express very little of this receptor (STL cells). The results of the study clearly indicate that these variants show a differential gene-expression profile. They differ in expression of some integrins such as VLA2, VLA3 and VLA6, of neuroendocrine-markers such as CD56 and synaptophysin, in the expression of c-kit and in the secretion of certain cytokines and growth factors such as TNFalpha, SDF-1, VEGF, IL-8, GM-CSF and IP-10. We hypothesize that these differences are due to an autocrine SDF-1alpha-CXCR4 axis. 相似文献
107.
Vermian epidermoid cyst developing in the fourth ventricle is very rare. We report a case observed in a 24-year-old man, who presented severe headache, dizziness and a blurred vision following head injury. Examination revealed a discrete gait disturbance. Cerebral CT-scan showed a large hypodense lesion of the posterior fossa without contrast enhancement. MRI demonstrated the vermian location of this lesion which displaced the roof of the fourth ventricle upward and the brainstem forward. A suboccipital approach allowed total removal of a well-encapsulated epidermoid cyst, non adherent to the floor of the fourth ventricle. The postoperative course was uneventful. 相似文献
108.
Possible direct cytoxicity effects of cyclophosphamide on cultured human follicles: an electron microscopy study 总被引:2,自引:0,他引:2
Raz A Fisch B Okon E Feldberg D Nitke S Raanani H Abir R 《Journal of assisted reproduction and genetics》2002,19(10):500-506
Purpose
: To evaluate the direct effect of cyclophosphamide on cultured human ovarian follicles.
Methods
: Human ovarian cortical slices from premenopausal women were incubated with medium containing cyclophosphamide (0.0005–0.5 mg/mL) for 2–48 h and assessed by transmission electron microscopy. Noncultured specimens and samples cultured without cyclophosphamide were used as controls.
Results
: There were significantly more damaged granulosa cell nuclei after incubation with 0.5 mg/mL cyclophosphamide for at least 4 h. There were also more changes in the basement membrane after incubation with cyclophosphamide at concentrations of 0.05 and 0.5 mg/mL.
Conclusions
: Although the cyclophosphamide dose that caused damage to the granulosa cell nuclei was above the pharmacological level, our results suggest that cyclophosphamide, and not only its active metabolite phospharamide mustard, might have a destructive effect on human follicles, as it remains in the circulation longer. This effect could be mediated by damage to the granulosa cells and perhaps the basement membrane. 相似文献
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Nudel Itay Pokhojaev Ariel Hausman Bryan S. Bitterman Yoli Shpack Nir May Hila Sarig Rachel 《International journal of legal medicine》2020,134(5):1853-1860
International Journal of Legal Medicine - Unlike bones, teeth are remarkably resilient and can withstand severe trauma, making age assessment based on the dentition essential for forensic analysis.... 相似文献