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31.
Abdullah M. Alotaibi Katelyn A. Craig Taghreed M. Alshareef Elham S. AlQathmi Sarah M. Aman Hesham M. Aldhalaan Cheryl L. Oandasan 《Saudi medical journal》2021,42(8):878
Objectives:To assess how clinical services are accessed and utilized by young children with suspected autism spectrum disorder (ASD) and identifying factors that prevent the early identification of developmental concerns and diagnosis.Methods:This retrospective study examined the sociodemographic and clinical characteristics of a convenience sample of children diagnosed with ASD at the Center for Autism Research, Riyadh, Saudi Arabia between 2016 and 2018. The characteristics of ASD assessment and intervention service use were examined. Additionally, we examined the association between sociodemographic, clinical, and service use variables with the child’s age at the time of the parent’s initial concern and first ASD diagnosis, and the time from first concern to diagnosis.Results:Out of 127 cases, 67 were diagnosed with ASD (mean: 46.88 months, SD: 18.88, median: 42.00, range, 19-93). Most ASD cases had one previous assessment (n=28, 41.8%). Higher sibling numbers were associated with a later age of first concern (p=0.0278). Applied behavior analysis service utilization was associated with later age of first ASD diagnosis (p=0.0336) and longer time to ASD diagnosis (p=0.0301).Conclusion:Larger sample size is needed to further investigate whether these findings are representative of the national experience. Community-based intervention outcome studies should assess the quality of services being provided. 相似文献
32.
Growing concerns about the possible toxicity of silver to aquatic organisms, bacteria, and humans have led to newly issued regulations by the United States Environmental Protection Agency (US EPA) and the Food and Drug Administration (FDA) regarding the use of silver. However, the increase in bacterial resistance to antibiotics has led to a resurgence in the use of silver as a biocidal agent in applications ranging from washing machine additives to the drinking water treatment system on the International Space Station (ISS). For Ag+ ion detection, a highly sensitive and reversible optical sensor has been established. The optode relies on a novel Schiff base, namely 2-[(benzo[d]thiazol-2-ylimino)methyl]phenol (BTMP) immobilized within PVC film and also incorporated with tris(2-ethylhexyl)phosphate (TEHP) and Aliquat 336 as an ion carrier. Under optimum conditions (i.e. pH 8.5), the proposed sensor displayed a linear response to Ag+ over 4.8 × 10−9 to 1.0 × 10−5 M (0.8494–1698.7 μg L−1) with limits of detection and quantification of 1.5 × 10−9 and 4.8 × 10−9 M (0.2548 and 0.8494 μg L−1), respectively. The sensor''s response time was found to be 8.0 min. The sensor was applied successfully to determine Ag+ ion in some real samples, including food, biological, water, and environmental samples.Growing concerns about the possible toxicity of silver to aquatic organisms, bacteria and humans have led to newly issued regulations by the United States Environmental Protection Agency and the Food and Drug Administration regarding the use of silver. 相似文献
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El-Awady MK Mostafa L Tabll AA Abdelhafez TH Bader El Din NG Zayed N Shenawy RE El Abd Y Hasan RM Zaghlol H El Khayat H Abdel Aziz AO 《Hepatitis monthly》2012,12(4):271-277
Background
IL28B single nucleotide polymorphisms (SNPs) play important roles in the management of hepatitis C virus (HCV) infections and are strongly associated with spontaneous and treatment-induced HCV clearance.Objectives
In the present study, the association between IL28B variants and the progression of HCV infection in Egyptian patients infected with type 4a virus will be examined.Patients and Methods
Frequencies of the protective genotype C/C of SNP, rs12979860 were determined in healthy subjects, spontaneous resolvers, and chronic HCV type 4 patients with low F scores and in patients with end stage liver disease (ESLD). This study included a total of 404 subjects. Patients infected with HCV type 4a (n = 304) were divided into; chronic hepatitis C (CHC) with low F scores (CHC, n = 110), end stage liver disease (n = 110), liver cirrhosis (LC) (n = 35) and hepatocellular carcinoma (HCC) patients (n = 75), spontaneous resolvers of HCV infection (n = 84) were also included. A healthy group representing the Egyptian population (n = 100) was also included in the genotyping of IL28B. The later was typed via a polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP) assay analysis on purified genomic DNA extracted from all individuals.Results
A significant increase (P < 0.0005) was observed in frequencies of IL-28B rs12979860 C/C genotypes in the healthy population, than in the CHC, LC and HCC groups (C/C = 48%, 13%, 0%.and 0% respectively). On the other hand the C/C genotype was significantly higher (P < 0.0005) in spontaneous resolvers than in healthy subjects. A comparable significant increase in the frequency of C/T allele accompanied by mild elevation of T/T allele frequency, were detected along the progression towards ESLD.Conclusions
Genotype C/C is associated with viral clearance during acute infection. The sharp decline in the C/C genotype from healthy to CHC subjects and the total absence of the C/C genotype in ESLD suggests a central role of this genotype against HCV disease progression. 相似文献36.
37.
Al-Mekhlafi MS Atiya AS Lim YA Mahdy AK Ariffin WA Abdullah HC Surin J 《The Southeast Asian journal of tropical medicine and public health》2007,38(6):998-1007
Despite great development in socioeconomic status throughout 50 years of independence, Malaysia is still plagued with soil-transmitted helminthiases (STH). STH continue to have a significant impact on public health particularly in rural communities. In order to determine the prevalence of STH among rural Orang Asli children and to investigate the possible risk factors affecting the pattern of this prevalence, fecal samples were collected from 292 Orang Asli primary schoolchildren (145 males and 147 females) age 7-12 years, from Pos Betau, Kuala Lipis, Pahang. The samples were examined by Kato-Katz and Harada Mori techniques. Socioeconomic data were collected using pre-tested questionnaires. The overall prevalence of ascariasis, trichuriasis, and hookworm infections were 67.8, 95.5 and 13.4%, respectively. Twenty-nine point eight percent of the children had heavy trichuriasis, while 22.3% had heavy ascariasis. Sixty-seven point seven percent of the children had mixed infections. Age > 10 years (p = 0.016), no toilet in the house (p = 0.012), working mother (p = 0.040), low household income (p = 0.033), and large family size (p = 0.028) were identified as risk factors for ascariasis. Logistic regression confirmed low income, no toilet in the house and working mother as significant risk factors for ascariasis. The prevalence of STH is still very high in rural Malaysian communities. STH may also contribute to other health problems such as micronutrient deficiencies, protein-energy malnutrition and poor educational achievement. Public health personnel need to reassess current control measures and identify innovative and integrated ways in order to reduce STH significantly in rural communities. 相似文献
38.
Ezzeldeen S. El Denshary Mohammad A. Al-Gahazali Fathia A. Mannaa Hesham A. Salem Nabila S. Hassan Mosaad A. Abdel-Wahhab 《Experimental and toxicologic pathology》2012,64(7-8):753-760
Liver diseases are amongst the most serious health problems in the world today and hepatocellular carcinoma is one of the world's deadliest cancers. The aim of the current study was to evaluate the protective effect of sider honey and/or Korean ginseng extract (KGE) against carbon tetrachloride (CCl4)-induced hepato-nephrotoxicity in rat. Eighty male Sprague-Dawley (SD) rats were allocated into different groups and over a 4-week period, they orally received honey and/or KGE or were treated either with CCl4 alone (100 mg/kg b.w) or with CCl4 after a pretreatment period with honey, KGE or a combination of both. Clinical, clinico-pathological and histopathological evaluations were done and CCl4-treated groups were compared with rats receiving no treatment and with rats given honey, KGE or a combination of these substances. The results indicated that oral administration of CCl4 induced severe hepatic and kidney injury associated with oxidative stress. The combined treatment with CCl4 plus honey and/or KGE resulted in a significant improvement in all evaluated parameters. This improvement was prominent in the group receiving CCl4 after combined pretreatment with honey and KGE. Animals receiving honey and/or KGE (without CCl4-treatment) were comparable to the control untreated group. It could be concluded that honey and KGE protect SD rats against the severe CCl4-induced hepatic and renal toxic effects. Our results suggest that the protective activity of honey and KGE may have been related to their antioxidant properties. 相似文献
39.
This study included 86 women presented with asymmetric breast densities, seen on either routine screening or diagnostic mammogram. 相似文献
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