全文获取类型
收费全文 | 560篇 |
免费 | 25篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 27篇 |
妇产科学 | 3篇 |
基础医学 | 78篇 |
口腔科学 | 2篇 |
临床医学 | 40篇 |
内科学 | 71篇 |
皮肤病学 | 7篇 |
神经病学 | 7篇 |
特种医学 | 143篇 |
外科学 | 26篇 |
综合类 | 31篇 |
预防医学 | 25篇 |
眼科学 | 2篇 |
药学 | 79篇 |
中国医学 | 3篇 |
肿瘤学 | 48篇 |
出版年
2020年 | 3篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2016年 | 4篇 |
2015年 | 6篇 |
2014年 | 7篇 |
2013年 | 19篇 |
2012年 | 6篇 |
2011年 | 7篇 |
2010年 | 12篇 |
2009年 | 16篇 |
2008年 | 13篇 |
2007年 | 19篇 |
2006年 | 7篇 |
2005年 | 10篇 |
2004年 | 13篇 |
2003年 | 17篇 |
2002年 | 20篇 |
2001年 | 19篇 |
2000年 | 12篇 |
1999年 | 16篇 |
1998年 | 46篇 |
1997年 | 38篇 |
1996年 | 18篇 |
1995年 | 16篇 |
1994年 | 16篇 |
1993年 | 16篇 |
1992年 | 8篇 |
1991年 | 11篇 |
1990年 | 15篇 |
1989年 | 11篇 |
1988年 | 15篇 |
1987年 | 15篇 |
1986年 | 20篇 |
1985年 | 23篇 |
1984年 | 10篇 |
1983年 | 11篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 4篇 |
1975年 | 7篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1940年 | 2篇 |
1933年 | 1篇 |
排序方式: 共有596条查询结果,搜索用时 15 毫秒
71.
72.
73.
74.
75.
Acute renal rejection versus acute tubular necrosis in a canine model: MR evaluation 总被引:1,自引:0,他引:1
Findings of magnetic resonance (MR) imaging in acute renal rejection and acute tubular necrosis (ATN) were studied in dogs. On T1-weighted images, corticomedullary differentiation was absent in kidneys undergoing acute rejection. The loss of corticomedullary differentiation in these kidneys was secondary to a decrease in the relative signal intensity of the cortex, indicating prolongation of the T1 relaxation time of the cortex. In contrast, corticomedullary differentiation was preserved on T1-weighted images of autotransplanted kidneys and kidneys with ATN. MR imaging findings correlated with changes in water content in these three groups of kidneys. Kidneys undergoing acute rejection showed a marked increase in water content compared with kidneys in the other two groups. No change in fat content was found in any group. 相似文献
76.
77.
78.
Granulocyte-macrophage colony-stimulating factor mRNA stabilization enhances transgenic expression in normal cells and tissues 总被引:3,自引:1,他引:2
To increase transgenic production of granulocyte-macrophage colony- stimulating factor (GM-CSF), we mutated the mRNA's 3'-untranslated region, AUUUA instability elements. Expression vectors containing human or murine GM-CSF cDNAs coding for wild-type (GM-AUUUA) or mutant versions with reiterated AUGUA repeats (GM-AUGUA) were transfected into cells in culture or animals using particle-mediated gene-transfer technology. Normal peripheral blood mononuclear cells accumulated 20- fold greater levels of GM-CSF mRNA and secreted comparably greater amounts of cytokine after transfection with hGM-AUGUA expression vectors versus hGM-AUUUA. hGM-AUGUA mRNA was fivefold more stable (t 1/2 = 95 minutes) than hGM-AUUUA mRNA (t 1/2 = 20 minutes), accounting for elevated steady-state levels. Transfection site extracts and serum samples obtained 24 hours after gene transfer of hGM-AUGUA cDNA into mouse skin contained greater than 32 ng/mL and 650 pg/mL of GM-CSF protein, respectively, compared with 0.33 ng/mL and less than 8 pg/mL for hGM-AUUUA cDNA. GM-CSF produced from mGM-AUGUA cDNA transfected into rat abdominal epidermis induced a profound neutrophil infiltrate. These data suggest a novel strategy for enhanced production of biologically active cytokines by normal cells after in vivo gene transfer. 相似文献
79.
JK Kruit 《Clinical genetics》2008,73(3):227-228
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
Schneider et al. (2006)
Cell Metabolism: 4 (5): 377–389 相似文献
Schneider et al. (2006)
Cell Metabolism: 4 (5): 377–389 相似文献
80.
This paper considers certain statistical aspects of the problem of among-strain differences in cancer susceptibilities and how these differences may affect the design of toxicity assays. First, in order to investigate the magnitude of within-study, between-strain differences in tumor induction, the data of Innes et al. (1969) were examined. It was found that although there was a very high overall association between mouse strains with respect to the induction of hepatomas, several compounds showed evidence of strain-to-strain variability. Next, a number of long-term carcinogenicity studies with DDT were considered, and among-strain differences in cancer susceptibility for this compound were noted. Finally, it was shown that if susceptible subgroups do exist and certain simplifying assumptions are made, then in many cases tumor increases can be detected more readily by using several inbred mouse strains for study rather than a single outbread stock. 相似文献