全文获取类型
收费全文 | 8549篇 |
免费 | 441篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 139篇 |
儿科学 | 418篇 |
妇产科学 | 241篇 |
基础医学 | 859篇 |
口腔科学 | 212篇 |
临床医学 | 712篇 |
内科学 | 2039篇 |
皮肤病学 | 146篇 |
神经病学 | 593篇 |
特种医学 | 281篇 |
外科学 | 1681篇 |
综合类 | 174篇 |
一般理论 | 2篇 |
预防医学 | 366篇 |
眼科学 | 197篇 |
药学 | 497篇 |
中国医学 | 33篇 |
肿瘤学 | 439篇 |
出版年
2023年 | 78篇 |
2022年 | 225篇 |
2021年 | 342篇 |
2020年 | 218篇 |
2019年 | 249篇 |
2018年 | 290篇 |
2017年 | 187篇 |
2016年 | 242篇 |
2015年 | 262篇 |
2014年 | 379篇 |
2013年 | 512篇 |
2012年 | 678篇 |
2011年 | 678篇 |
2010年 | 380篇 |
2009年 | 322篇 |
2008年 | 500篇 |
2007年 | 537篇 |
2006年 | 516篇 |
2005年 | 458篇 |
2004年 | 426篇 |
2003年 | 370篇 |
2002年 | 302篇 |
2001年 | 104篇 |
2000年 | 83篇 |
1999年 | 70篇 |
1998年 | 38篇 |
1997年 | 22篇 |
1996年 | 33篇 |
1995年 | 38篇 |
1994年 | 30篇 |
1993年 | 29篇 |
1992年 | 44篇 |
1991年 | 51篇 |
1990年 | 28篇 |
1989年 | 43篇 |
1988年 | 29篇 |
1987年 | 21篇 |
1986年 | 24篇 |
1985年 | 20篇 |
1984年 | 18篇 |
1983年 | 15篇 |
1982年 | 8篇 |
1981年 | 21篇 |
1980年 | 14篇 |
1979年 | 10篇 |
1978年 | 9篇 |
1977年 | 10篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1967年 | 12篇 |
排序方式: 共有9029条查询结果,搜索用时 15 毫秒
11.
Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment. 总被引:1,自引:0,他引:1
Murat Eren Ozen Mehmet Yumru Haluk A Savas Neslihan Cansel Hasan Herken 《The world journal of biological psychiatry》2007,8(1):42-44
Neuroleptic malignant syndrome (NMS) is the rarest and most serious of the neuroleptic-induced movement disorders. We describe a case of neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone. Although conventional neuroleptics are more frequently associated with NMS, atypical antipsychotic drugs like ziprasidone may also be a cause. The patient is a 24-year-old male with a history of schizophrenia who developed signs and symptoms of NMS after 2 days of treatment with an 80-mg/day dose of orally administrated ziprasidone. This case is the earliest (second day of treatment) NMS due to ziprasidone reported in the literature. 相似文献
12.
Dr. Hasan Horoz MD Dr. Hansan H. Erbil MD Varol Sen MD Esma Duru MD Dr. Hale Aral MD 《Annals of Ophthalmology》2005,37(4):267-271
We investigated the effects of activated protein C resistance (APCR), Factor V Leiden (FVL) mutation, and high lipoprotein
(a) levels in 32 young patients with branch retinal vein occlusion (BRVO) vs 30 controls. No difference between patients with
BRVO and controls was found with regard to APCR, FVL mutation, or lipoprotein (a) levels. These factors do not seem important
in the etiology of BRVO.
The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer
or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes
unlabeled, unapproved, or investigative products or devices. 相似文献
13.
S. F. Hashmi S. A. Hasan M. Aslam A. Shakoor 《Indian journal of otolaryngology and head and neck surgery》1995,47(2):119-121
100 cases of either sex 96 males and 4 females in their mean age group of 45 year ± 14.51 standard deviation were selected for this study to analyse the Hearing Acuity in the post spinal analgesia period during a period of eight months in the E.N.T department of the J.N. Medical College A.M.U. Aligarh. The size of the needle used for spinal analgesia was 22G and the equipment for Audiometry was the pure tone Audiometer. Pure tone Audiometry was done pre-operatively and then on the 1st, 3rd, 5th and 12th subsequent post-operative days and then after six months. It was found that 12% of the patients showed incidence of mild hearing loss. However, the loss was transient, reversible, within low frequency range (250, 500, 1000 Hz), and no patient suffered from any permanent hearing loss. 相似文献
14.
We describe a highly efficient stable gene transfection procedure for Chinese hamster ovary (CHO) cells using a modification of the calcium phosphate-DNA coprecipitation method. We have found that treatment of CHO cells with chloroquine increases the efficiency of gene transfer by up to 20-fold (from approx. 0.01% to approx. 0.2%) when transfection is done using the pSV2-neo plasmid. The optimized transfection procedure requires that CHO cells to be incubated with calcium phosphate-DNA coprecipitate and chloroquine (100 µM) for a total of 16 h. By using high-molecular-weight human genomic DNA as a DNA source for transfection, we show that this procedure is equally efficient for stably transferring a much larger gene, such as the 49-kb human hypoxanthine phosphoribosyltransferase gene. 相似文献
15.
16.
Zafer Sinik Turgut Alkibay Oumür Ataoglu Hasan Biri Sinan Sözen Nuri de Niz Uustünol Karaoglan Ibrahim Bozkirli 《International journal of urology》1997,4(6):546-551
Background :
The aim of this study was to examine nuclear p53 overexpression in transitional cell carcinoma of the bladder, adenocarcinoma of the prostate, and renal cell carcinoma.
Methods :
Forty-four pathologic specimens from 39 bladder cancer patients, 41 prostatic adenocarcinoma, and 39 renal cell carcinoma specimens were analyzed immunohistochemically with D07 monoclonal antibody to detect the expression of the mutant p53 gene. Overexpression was said to occur when the number of positively-stained tumor nuclei were≥ 10% in each specimen. p53 overexpression was correlated with the clinical and histopathological features of these cancers.
Results :
Nuclear p53 overexpression occurred in 18.2% of transitional cell bladder cancer specimens, 12.2% of prostate cancer specimens, and 17.9% of renal cell cancer specimens. Statistical analyses showed that grade, vascular invasion, and necrosis in bladder cancer, a high Gleason score in prostate cancer, and the 1-year mortality rate in renal cancer were significantly related with p53 nuclear overexpression (P<0.05).
Conclusion :
Using the D07 monoclonal antibody, nuclear p53 overexpression is relatively uncommon in urologic malignancies, and moderately correlates with several histopathological and clinical features of urologic malignancies. 相似文献
The aim of this study was to examine nuclear p53 overexpression in transitional cell carcinoma of the bladder, adenocarcinoma of the prostate, and renal cell carcinoma.
Methods :
Forty-four pathologic specimens from 39 bladder cancer patients, 41 prostatic adenocarcinoma, and 39 renal cell carcinoma specimens were analyzed immunohistochemically with D07 monoclonal antibody to detect the expression of the mutant p53 gene. Overexpression was said to occur when the number of positively-stained tumor nuclei were≥ 10% in each specimen. p53 overexpression was correlated with the clinical and histopathological features of these cancers.
Results :
Nuclear p53 overexpression occurred in 18.2% of transitional cell bladder cancer specimens, 12.2% of prostate cancer specimens, and 17.9% of renal cell cancer specimens. Statistical analyses showed that grade, vascular invasion, and necrosis in bladder cancer, a high Gleason score in prostate cancer, and the 1-year mortality rate in renal cancer were significantly related with p53 nuclear overexpression (P<0.05).
Conclusion :
Using the D07 monoclonal antibody, nuclear p53 overexpression is relatively uncommon in urologic malignancies, and moderately correlates with several histopathological and clinical features of urologic malignancies. 相似文献
17.
Effects of Hypothermia on Blood Endogenous Endotoxin Levels During Cardiopulmonary Bypass 总被引:1,自引:0,他引:1
Hakan Gerçekoglu M.D. Ozhan Tarim M.D. † Ismail Agar M.D. †† Ahmet Korukçu M.D. Hasan Karabulut M.D. Hüseyin Soydemir M.D. Onur Sokullu M.D. Hüseyin Toklu M.D. Candan B. Johansson Ph.D. † Besim Yigiter M.D. Ercüment Kopman M.D. †† 《Journal of cardiac surgery》1997,12(4):223-227
A bstract Endotoxin activates white blood cells and complement and produces a spectrum of clinical syndromes ranging from fever to septic shock. Although production of endogenous endotoxemia during cardiopulmonary bypass (CPB) has recently been reported, the role of hypothermia on endotoxemia is not clear. In this study, we evaluated the effects of moderate (24–28°C) and mild (32–34°C) hypothermia on blood endotoxin levels. The study population consisted of 20 patients who underwent coronary artery bypass grafting (CABG) with CPB. Moderate systemic hypothermia was applied during aortic cross-clamping in ten patients (group 1) and mild hypothermia in the remaining ten patients (group 2). The mean rectal temperatures were 26.8 ± 1.2°C in group 1 and 33.8 ± 0.8°C in group 2. The blood samples for endotoxin level measurements were obtained before CPB, during aortic cross-clamping, immediately after the release of the cross-clamp, 20 minutes after the release of the cross-clamp, after CPB, and 2 hours postoperatively. There were no endotoxins in any of the samples before CPB, but it was detected after CPB in both groups. The endotoxin levels were significantly higher in group 1 than in group 2. The present study suggests that when hypothermia is the technique of choice, the deleterious effects of endotoxemia on patients with comorbidity must be considered. 相似文献
18.
Kevin Brooks Hanem Hasan Sridhar Samineni Venu Gangur Wilfried Karmaus 《Pediatric allergy and immunology》2007,18(7):621-624
Placental p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) concentration and cord blood atopic markers were determined in 19 neonates. Increased placental p,p'-DDE was associated with a statistically significant increase in cord plasma interleukin (IL)-13. Furthermore, both cord plasma IL-4/interferon (IFN)-gamma and IL-13/IFN-gamma ratios were significantly positively associated with placental p,p'-DDE concentration. 相似文献
19.
Brian A. McGovern M.D. Hasan Garan M.D. Jeremy N. Buskin M.D. 《Current problems in cardiology》1988,13(12):790-859
Within the past 20 years, our knowledge concerning the epidemiology, natural history, and treatment of VT has expanded greatly. A variety of effective pharmacologic, surgical and electrical therapies for VT are now available to the clinician. Patients who present with ventricular, tachyarrhythmias should undergo a comprehensive medical evaluation directed at identifying and treating such factors as ischemia, congestive heart failure, valvular heart disease, sensitivity to cardioactive drugs, and metabolic derangements. Many patients who present with asymptomatic ventricular arrhythmias do not require specific antiarrhythmic drug therapy. However, certain patients who have already suffered a life-threatening arrhythmia or who are at high risk for such arrhythmia should be vigorously treated with specific antiarrhythmic therapy guided for that individual patient. The efficacy of any antiarrhythmic treatment should be assessed by ECG monitoring, exercise testing, and/or electrophysiologic study. In the near future, potentially revolutionary new electrical therapies for ventricular tachyarrhythmias will be evaluated. It is to be hoped that these devices used in combination with pharmacologic and surgical therapies may dramatically reduce the incidence of sudden cardiac death in high-risk patients. 相似文献
20.
Gall bladder hydatid cyst is a rare entity. Concurrent occurrence of gall blader hydatid cysts along with liver cysts, especially with the biliary channels clear of cysts, is very rare. We report a 27-year-old man with a gall bladder hydatid cyst that was diagnosed only after opening the resected specimen of the gall bladder. 相似文献