接种抗HPV-16癌基因蛋白疫苗治疗外阴上皮内瘤样变

背景及目的：最近，关于叶酸的安全性引起了广泛的关注，尤其是其与肿瘤风险的关系。本研究是通过两项随机对照试验评价叶酸和维生素B治疗对肿瘤发生率和全因死亡率的影响。     

Streptococcus dysgalactiae Bloodstream Infections,Norway, 1999–2021

Streptococcus dysgalactiae increasingly is recognized as a pathogen of concern for human health. However, longitudinal surveillance data describing temporal trends of S. dysgalactiae are scarce. We retrospectively identified all β-hemolytic streptococcal bloodstream infections reported in Bergen, in western Norway, during 1999–2021. To explore S. dysgalactiae disease burden in a broader context, we mapped the incidence of all microbial species causing bloodstream infections during 2012–2021. We found S. dysgalactiae incidence rates substantially increased during the study period; by 2021, S. dysgalactiae was the fifth most common pathogen causing bloodstream infections in our region. We noted genotypic shifts and found that the rising trend was related in part to the introduction and expansion of the stG62647 emm-type. S. dysgalactiae is among the most common causes of bloodstream infections in western Norway, and increased surveillance and unambiguous species identification are needed to monitor the disease burden attributable to this pathogen.     

Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands

Despite many efforts, the nature of thymic immigrants that give rise to T cells has remained obscure, especially since it became known that extrathymic lineage-negative, Sca-1-positive, c-kit high progenitor cells differ from intrathymic early T cell progenitors (ETPs) by functional potential and dependence on Notch signaling. After our observation that intrathymic T cell precursors expressing a human CD25 reporter under control of pre-TCRalpha regulatory elements almost exclusively have the ETP phenotype, we have analyzed the phenotypic changes of reporter-expressing common lymphoid progenitor (CLP) cells in the bone marrow when cultured on Delta-like 1-expressing stromal cells. We note that these quickly adopt the phenotype of double negative (DN)2 thymocytes with little display of the ETP phenotype. Our data suggest that common lymphoid progenitor (CLP) cells could be responsible for the rapid reconstitution of thymus function after bone marrow transplantation since CLP cells in the blood have the capacity to rapidly enter the thymus and become DN2 thymocytes.     

The collagen content of skin and gingival tissues in ascorbic acid-deficient monkeys

Five green monkeys were used in this study. Three animals were fed a scorbutigenic diet and the remaining two served as controls. Biopsies were dissected from the vestivular gingiva and dorsal skin and polyvinyl sponges were implanted subcutaneously during 4 week periods throughout the experimental period. The animals were sacrificed after 12 weeks and the periodontal ligament was removed. Collagen extracts were prepared from the gingival and granulation tissues and treated with bacterial collagenase. Following acid hydrolysis the total amount of proline and hydroxyproline was determined in various tissue preparations. In the tissues examined, the content of hydroxyproline decreased in the scorbutic animals throughout the experimental period. The decrease in the hydroxyproline content of the gingiva started within the first 4 weeks and was faster than that of the skin, indicating that the extent of decrease is dependent of the turnover rate of the collagen in the tissues. The synthesis of hydroxyproline was almost totally impaired in the granulation tissue formed in the sponges implanted after the 8th week of experimentation. Collagenase treatment of collagen extracts resulted in a release of proline and hydroxyproline in a higher ratio in extracts from the experimental animals than in extracts from the controls. It is concluded that ascorbic acid is a prerequisite for the maintenance of the collagen pool in the tissues and that lack of this vitamin results in the formation of a collagenase degradable protein fraction with a low hydroxyproline content.     

Vergiftungen durch Trinitrotoluol und durch Tetranitromethylanilin

Ohne Zusammenfassung     

Literaturübersicht

Ohne Zusammenfassung     

Experimentelle Allergie

Research in Experimental Medicine - Es stand zur Untersuchung, welche Aufgaben einerseits den Organen und andererseits dem Blut allergischer Tiere im Ablauf der Antikörper-Antigenreaktion...