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61.
62.
Rami Madanat Tatu J M?kinen Hannu T Aro Charles Bragdon Henrik Malchau 《Acta orthopaedica》2014,85(5):447-455
Background and purpose
Guidelines for standardization of radiostereometry (RSA) of implants were published in 2005 to facilitate comparison of outcomes between various research groups. In this systematic review, we determined how well studies have adhered to these guidelines.Methods
We carried out a literature search to identify all articles published between January 2000 and December 2011 that used RSA in the evaluation of hip or knee prosthesis migration. 2 investigators independently evaluated each of the studies for adherence to the 13 individual guideline items. Since some of the 13 points included more than 1 criterion, studies were assessed on whether each point was fully met, partially met, or not met.Results
153 studies that met our inclusion criteria were identified. 61 of these were published before the guidelines were introduced (2000–2005) and 92 after the guidelines were introduced (2006–2011). The methodological quality of RSA studies clearly improved from 2000 to 2011. None of the studies fully met all 13 guidelines. Nearly half (43) of the studies published after the guidelines demonstrated a high methodological quality and adhered at least partially to 10 of the 13 guidelines, whereas less than one-fifth (11) of the studies published before the guidelines had the same methodological quality. Commonly unaddressed guideline items were related to imaging methodology, determination of precision from double examinations, and also mean error of rigid-body fitting and condition number cutoff levels.Interpretation
The guidelines have improved methodological reporting in RSA studies, but adherence to these guidelines is still relatively low. There is a need to update and clarify the guidelines for clinical hip and knee arthroplasty RSA studies.Since the introduction of radiostereometry (RSA) in 1974, the method has continuously proven to be a valuable tool in the assessment of migration following hip and knee arthroplasty. Although the importance of a stepwise introduction of new orthopedic implants was presented in 1995 (Malchau 1995), only recently has it been fully acknowledged that deletion of some of these crucial steps can have catastrophic consequences (Kärrholm 2012). The phased or stepwise introduction process is based on the hypothesis that a more precise and careful evaluation of new implants will reduce the number of patients at risk of unexpected failures. There are 4 suggested steps to this process (Malchau 1995). The initial step involves preclinical implant testing. After this, the first clinical step consists of prospective randomized studies that use RSA. The second clinical step involves multicenter studies and the final step is composed of registry studies.The detection of early migration or accelerated wear using RSA are ways of predicting early implant failure, and are therefore important components of this stepwise introduction process (Kärrholm 2012). Although RSA would probably not have been able to forecast some of the problems related to the metal-on-metal articulation, it could have prevented the premature introduction of Boneloc cement. When Boneloc was introduced, the Norwegian Arthroplasty Register needed more than 1,000 patients before it could be proven to be an inferior cement based on a higher revision rate compared to regular bone cement (Havelin et al. 1995). Using RSA only, 30 patients were included in a study that—already after 6 months—showed that Boneloc-cemented implants were clearly less stable than those with conventional bone cement (Thanner et al. 1995). If Boneloc had been studied with RSA prior to being released onto the market, thousands of patients would have been spared from early revision. There are several other examples of poor orthopedic implants or materials that should have been tested with RSA prior to widespread release (Muirhead-Allwood 1998, Norton et al. 2002). In the past, many serious problems initially manifested as low-incidence events but only later proved to be the tip of the iceberg (Malchau et al. 2011). Despite the fact that the algorithm for introduction of new implant designs was established more than 15 years ago, many new and untested implants still appear on the market. The orthopedic community has acknowledged that the fast spread of undocumented new implants is no longer acceptable (Kärrholm 2012).With the increasing importance of RSA, it has also been recognized that reporting of RSA outcomes should be standardized. The guidelines for standardization of radiostereometry of implants were published in August 2005, to facilitate comparison of RSA outcomes reported from different centers (Valstar et al. 2005). In that paper, an appendix of 13 main items that should be used to account for the results of a clinical RSA study is outlined. Furthermore, since RSA is a highly technical method, the reliability and reproducibility of a study can only be assessed when all standardized output items have been adequately addressed.We investigated whether the RSA guidelines have resulted in improved methodological reporting in clinical RSA studies of hip and knee arthroplasty. We also assessed the overall level of adherence to each of the individual guidelines following their introduction. 相似文献63.
Päivi E. Korhonen Tellervo Seppälä Salme Järvenpää Hannu Kautiainen 《Quality of life research》2014,23(1):67-74
Purpose
Obesity is known to be associated with a range of chronic medical comorbidities, but little is known about the impact of overweight and obesity on health-related quality of life (HRQoL) in persons without chronic diseases. The aim of this study was to assess HRQoL, body mass index (BMI) and health behavior patterns in a community sample of subjects who had no long-lasting medical comorbiditiesMethods
We assessed HRQoL in 1,187 apparently healthy individuals (mean age 57 ± 7 years), of whom 24 % were classified as normal weight, 49 % as overweight, 20 % as obese and 7 % as very obese. Two different instruments of HRQoL were used: the generic Short-Form Health Survey (SF-36) questionnaire and the preference-based instrument EuroQol (EQ-5D).Results
All physical components of the SF-36 decreased linearly according to BMI categories in women. In men, only poorer physical functioning scale showed linearity with rising BMI. Scores on the mental components of the SF-36 did not differ by BMI categories in either gender. The EQ-5D index and EuroQol visual analogue scale scores decreased linearly with rising BMI only in women.Conclusions
In apparently healthy middle-aged subjects, physical HRQoL decreases with increasing level of BMI and more so in women than in men. Mental components of HRQoL do not differ between the categories of BMI in either gender. 相似文献64.
Acute stress can affect cognitive processing and decrease performance in demanding, stressful situations. Here, we recorded the cardiac indices of stress, that is, the heart rate and heart rate variability together with the physical activity of nuclear power plant operators, and examined their association with crew performance, while the operator crews were managing simulated incident and accident situations. Crew performance was evaluated both by the operator instructor and as the time taken to resolve the situation. In total, 64% of the variance in the information-seeking performance (adj-R2 = .64, p < .01), and 41% of variation in the performance time (adj-R2 = .41, p < .01) were explained by the psychophysiology. The cardiac measures indicated that increased stress was associated with poorer information-seeking performance and longer performance time. Increased physical activity was associated with poorer information seeking only. Otherwise, crew performance was robust, as the diagnosis and corrective actions, use of emergency operations procedures, and collaboration, were only weakly associated with the stress physiology. The association between information-seeking performance and stress might be explained by the larger requirement for cognitive processing at the information-gathering phase of the task. The results of the study show that psychophysiological measurements of stress and activity can provide valuable information on stress and its association with cognitive performance at work. 相似文献
65.
Anne Roivainen MSc Jari Jalava MSc Laura Pirilä MD Tuomas Yli-Jama MD Hannu Tiusanen MD Paavo Toivanen MD 《Arthritis \u0026amp; Rheumatology》1997,40(9):1636-1643
Objective. To examine mutational activation of ras proto-oncogenes in synovial tissue from patients with rheumatoid arthritis (RA) compared with synovial specimens from patients with osteoarthritis (OA) or other arthropathies. Synovial samples from cadavers, without any signs of joint disease, were used as control material. Methods. Using a combination of polymerase chain reaction (PCR) and automated sequencing of the amplified PCR product, regions around codons 12, 13, and 61 of the H-, K-, and N-ras proto-oncogenes were analyzed. Confirmation of mutations was based on restriction fragment length polymorphism analysis and/or oligonucleotide hybridization. Results. Four (6%) of 72 patients with RA, 2 (13%) of 16 with OA, and 1 (8%) of 12 with other arthropathies harbored mutant H-ras proto-oncogenes, and were heterozygous at codon 13 for the GGT→GAT (Gly→Asp) change. An unexpected mutation was found in the H-ras gene, in which a heterozygous GTG→ATG (Val→Met) mutation was observed over codon 14. The incidence for this mutation was 39% (28 of 72) in RA patients, 94% (15 of 16) in OA patients, and 42% (5 of 12) in patients with other arthropathies. All samples carrying the codon 13 mutation of H-ras were also codon 14-mutated, i.e., double mutations existed. Identical point mutations were also detected in a few synovial specimens obtained from cadavers (n = 8), including a single case of double mutation. All specimens showed normal K- and N-ras loci. Conclusion. Activation of proto-oncogene H-ras by point mutation in codons 13 and 14 occurred in the synovial tissue of patients with RA, OA, or other arthropathies, as well as, to some extent, in the control synovia, indicating that the phenomenon is not specific for RA. In codon 14, incidence of the H-ras point mutation was highest in OA tissue. The possible significance of this codon 14-mutated H-ras gene needs to be clarified. 相似文献
66.
67.
68.
Human impulsive aggression: a sleep research perspective 总被引:2,自引:0,他引:2
Lindberg N Tani P Appelberg B Naukkarinen H Rimón R Porkka-Heiskanen T Virkkunen M 《Journal of psychiatric research》2003,37(4):313-324
Impulsive aggression is commonly associated with personality disorders, in particular antisocial and borderline personality disorders as well as with conduct disorder and intermittent explosive disorder. The relationship between impulsive aggression and testosterone is well established in many studies. One of the aims of this study was to characterize the relationship between earlier-mentioned different categorical psychiatric diagnosis describing human impulsive aggression and sleep using polysomnography and spectral power analysis. Another aim was to study the relationship between serum testosterone and sleep in persons with severe aggressive behaviour. Subjects for the study were 16 males charged with highly violent offences and ordered for a pretrial forensic psychiatric examination. The antisocials with borderline personality disorder comorbidity had significantly more awakenings and lower sleep efficiency compared with the subjects with only antisocial personality disorder. The subjects with severe conduct disorder in childhood anamnesis had higher amount of S4 sleep and higher relative theta and delta power in this sleep stage compared with males with only mild or moderate conduct disorder. The same kind of sleep architecture was associated with intermittent explosive disorder. In subgroups with higher serum testosterone levels also the amount of S4 sleep and the relative theta and delta power in this sleep stage were increased. The study gives further support to the growing evidence of brain dysfunction predisposing to severe aggressive behaviour and strengthens the view that there are different subpopulations of individuals with antisocial personality varying in impulsiveness. The differences in impulsiveness are reflected in sleep architecture as well. 相似文献
69.
Ghannad F Nica D Fulle MI Grenier D Putnins EE Johnston S Eslami A Koivisto L Jiang G McKee MD Häkkinen L Larjava H 《The American journal of pathology》2008,172(5):1271-1286
Integrin alphavbeta6 is generally not expressed in adult epithelia but is induced in wound healing, cancer, and certain fibrotic disorders. Despite this generalized absence, we observed that alphavbeta6 integrin is constitutively expressed in the healthy junctional epithelium linking the gingiva to tooth enamel. Moreover, expression of alphavbeta6 integrin was down-regulated in human periodontal disease, a common medical condition causing tooth loss and also contributing to the development of cardiovascular diseases by increasing the total systemic inflammatory burden. Remarkably, integrin beta6 knockout mice developed classic signs of spontaneous, chronic periodontal disease with characteristic inflammation, epithelial down-growth, pocket formation, and bone loss around the teeth. Integrin alphavbeta6 acts as a major activator of transforming growth factor-beta1 (TGF-beta1), a key anti-inflammatory regulator in the immune system. Co-expression of TGF-beta1 and alphavbeta6 integrin was observed in the healthy junctional epithelium. Moreover, an antibody that blocks alphavbeta6 integrin-mediated activation of TGF-beta1 initiated inflammatory periodontal disease in a rat model of gingival inflammation. Thus, alphavbeta6 integrin is constitutively expressed in the epithelium sealing the gingiva to the tooth and plays a central role in protection against inflammatory periodontal disease through activation of TGF-beta1. 相似文献