全文获取类型
收费全文 | 308篇 |
免费 | 13篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 12篇 |
妇产科学 | 2篇 |
基础医学 | 24篇 |
口腔科学 | 11篇 |
临床医学 | 25篇 |
内科学 | 49篇 |
皮肤病学 | 5篇 |
神经病学 | 9篇 |
特种医学 | 155篇 |
外科学 | 6篇 |
综合类 | 3篇 |
预防医学 | 5篇 |
眼科学 | 1篇 |
药学 | 27篇 |
肿瘤学 | 6篇 |
出版年
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 4篇 |
2017年 | 1篇 |
2016年 | 9篇 |
2015年 | 12篇 |
2014年 | 9篇 |
2013年 | 4篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2010年 | 8篇 |
2009年 | 14篇 |
2008年 | 19篇 |
2007年 | 29篇 |
2006年 | 10篇 |
2005年 | 12篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 12篇 |
2001年 | 14篇 |
2000年 | 8篇 |
1999年 | 12篇 |
1998年 | 25篇 |
1997年 | 15篇 |
1996年 | 6篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 1篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 4篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 4篇 |
排序方式: 共有341条查询结果,搜索用时 0 毫秒
121.
KA Kaphingst FM Facio M‐R Cheng S Brooks H Eidem A Linn BB Biesecker LG Biesecker 《Clinical genetics》2012,82(5):408-415
Kaphingst KA, Facio FM, Cheng M‐R, Brooks S, Eidem H, Linn A, Biesecker BB, Biesecker LG. Effects of informed consent for individual genome sequencing on relevant knowledge. Increasing availability of individual genomic information suggests that patients will need knowledge about genome sequencing to make informed decisions, but prior research is limited. In this study, we examined genome sequencing knowledge before and after informed consent among 311 participants enrolled in the ClinSeq? sequencing study. An exploratory factor analysis of knowledge items yielded two factors (sequencing limitations knowledge; sequencing benefits knowledge). In multivariable analysis, high pre‐consent sequencing limitations knowledge scores were significantly related to education [odds ratio (OR): 8.7, 95% confidence interval (CI): 2.45–31.10 for post‐graduate education, and OR: 3.9; 95% CI: 1.05, 14.61 for college degree compared with less than college degree] and race/ethnicity (OR: 2.4, 95% CI: 1.09, 5.38 for non‐Hispanic Whites compared with other racial/ethnic groups). Mean values increased significantly between pre‐ and post‐consent for the sequencing limitations knowledge subscale (6.9–7.7, p < 0.0001) and sequencing benefits knowledge subscale (7.0–7.5, p < 0.0001); increase in knowledge did not differ by sociodemographic characteristics. This study highlights gaps in genome sequencing knowledge and underscores the need to target educational efforts toward participants with less education or from minority racial/ethnic groups. The informed consent process improved genome sequencing knowledge. Future studies could examine how genome sequencing knowledge influences informed decision making. 相似文献
122.
AF Finzi † LG Mantovani ‡ A Belisari‡ Italian Association for Studies on Psoriasis 《Journal of the European Academy of Dermatology and Venereology》2001,15(4):320-324
The objective of this study was to assess the cost of caring for patients with psoriasis in Italy according to the AISP study (Associazione Italiana Studi Psoriasi or Italian Association for Studies on Psoriasis), involving 104 university and hospital centres and 7992 patients in 1994. The mean yearly cost of care for a single patient was calculated at 905 Euros. Hospitalization accounted for more than four-fifths of the costs, therapy for about one-eighth (systemic therapies were the most expensive) and office visits and day hospitals for the remainder. In our study series less than 20% of patients accounted for more than 90% of the total costs. 相似文献
123.
124.
Breast metastases from extramammary malignancies 总被引:2,自引:0,他引:2
125.
鲜罗汉果中黄酮甙的分离及结构测定 总被引:12,自引:0,他引:12
A new flavonol glycoside named grosvenorine and a known compoundwere isolated from the fresh fruits of Siraitia grosvenori( swingle)C. By means of UV,FAB-MS,1H-1H COSY,13C-1H COSY and NOE difference ,spectra,the structure of grosvenorinewas established as kaempferol-3-O-α-L-rhafmnopyranoside-7-O[β-D-glucopyranosyl-(1-2)-α-L-rhamnopyranoside].The known compound was identified as kaempferol-3,7-α-L-dirhamnopyra-noside. 相似文献
126.
Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI 总被引:1,自引:0,他引:1
Chang S; Rosenberg MJ; Morton H; Francomano CA; Biesecker LG 《Human molecular genetics》1998,7(5):865-870
Glycogen storage disease type VI (GSD6) defines a group of disorders that
cause hepatomegaly and hypoglycemia with reduced liver phosphorylase
activity. The course of these disorders is generally mild, but definitive
diagnosis requires invasive procedures. We analyzed a Mennonite kindred
with an autosomal recessive form of GSD6 to determine the molecular defect
and develop a non-invasive diagnostic test. Linkage analysis was performed
using genetic markers flanking the liver glycogen phosphorylase gene ( PYGL
), which was suspected to be the cause of the disorder on biochemical
grounds. Mennonite GSD6 was linked to the PYGL locus with a multipoint LOD
score of 4.7. The PYGL gene was analyzed for mutations by sequencing
genomic DNA. Sequencing of genomic DNA revealed a splice site abnormality
of the intron 13 splice donor. Confirmation of the genomic mutation was
performed by sequencing RT-PCR products, which showed heterogeneous PYGL
mRNA lacking all or part of exon 13 in affected persons. This study is the
first to demonstrate that a mutation in the PYGL gene can cause GSD6. This
mutation is estimated to be present on 3% of Mennonite chromosomes and the
disease affects 0.1% of that population. Determination of this mutation
provides a basis for the development of a simple and non- invasive
diagnostic test for the disease and the carrier state in this population
and confirms biochemical data showing the importance of this gene in
glucose homeostasis.
相似文献
127.
128.
辽吉冰凉花总甙对心功能影响的实验研究 总被引:4,自引:0,他引:4
辽吉冰凉花总甙(APAW)1.0mg/kg iv,能使麻醉家兔正常心脏的P-dP/dt环体面积(LO),LV-dP/dt_(max),Vpm及LVSP比药前增大,HR减慢。APAW和冰凉花(AAR)及毒毛旋花子甙K(SK)一样,能明显改善衰竭兔心的心功能。静脉恒速输入0.5 mg/ml APAW,25min后,心衰家兔的LVSP,LV—dP/dt max,LO均明显回升,LVEDP降低,t-dP/dt max缩短。三种强心甙的最大强心效力无显著性差异。但APAW的治疗宽度和治疗指数均较AAR和SK为大,而AAR和SK间则无显著性差异。 相似文献
129.
Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis 总被引:10,自引:1,他引:9
Ohmen JD; Yang HY; Yamamoto KK; Zhao HY; Ma Y; Bentley LG; Huang Z; Gerwehr S; Pressman S; McElree C; Targan S; Rotter JI; Fischel-Ghodsian N 《Human molecular genetics》1996,5(10):1679-1683
In the Western world, chronic inflammatory bowel disease (IBD) presents as
two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC)
[Targan, S.R. and Shanahan, F. (1994). In Retford, D.C (ed.), Inflammatory
Bowel Disease: From Bench to Bedside. Williams and Wilkins, Baltimore].
Genetic epidemiological studies, the occurrence of rare syndromes
associated with IBD, and animal models suggest that inherited factors play
significant roles in the susceptibility to both forms of IBD [Yang, H.-Y.
and Rotter, J.I. (1995) In Kirsner, J.B. and Shorter, R.G. (eds). Genetic
Aspects of Idiopathic Inflammatory Bowel Disease. Williams and Wilkins,
Baltimore, pp.301-331]. Recently, a genome-wide search on European families
with multiple affected members with CD identified a putative susceptibility
locus in the centromeric region of chromosome 16 [Hugot, J.-P. et al.
(1996) Nature, 379, 821- 823]. We have now tested this region in an
independent set of US families, confirmed that this region is likely to
contain a gene predisposing to CD, and further refined the chromosomal
location of this gene. Most importantly with respect to this locus, our
data also seem to indicate that there is heterogeneity both within the CD
group, and between the CD and UC groups with respect to this locus. The
susceptibility locus appears to be involved only in non-Jewish CD sibpairs
and not in our Ashkenazi Jewish CD sibpairs. Additionally, we have tested
sibpairs having either only UC or both UC and CD for involvement of this
locus, and have found no evidence that this region predisposes to IBD in
these patients.
相似文献
130.
Avascular necrosis of the vertebral body: MR imaging 总被引:14,自引:0,他引:14
Five patients with plain radiographic evidence of a compressed vertebra containing an intravertebral vacuum cleft indicative of avascular necrosis underwent magnetic resonance (MR) imaging. In these patients, the T2-weighted images revealed a distinct appearance consisting of marked and discrete hyperintensity at the location of the intravertebral cleft. T1-weighted images were hypointense in this region. Recognition of this pattern is important in the MR imaging evaluation of compression fractures of the vertebral body so that confusion with malignancy or infection may be avoided, thereby obviating additional diagnostic studies. 相似文献