Presence of antibodies reacting specifically with structural proteins of mouse mammary tumor virus (MMTV) among antibodies composing circulating immune complexes in breast cancer patients

All-Union Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Trapeznikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 105, No. 4, pp. 475–477, April, 1988.     

艾氟隆无痛止血海绵用于鼻中隔手术后填塞止血效果观察

鼻腔黏膜神经末梢十分丰富，鼻腔手术后一直采用凡士林纱条作为填塞止血材料，但在填入和撤出过程中常给病人带来难以忍受的痛苦。因此，我院采用艾氟隆无痛止血海绵这一新型的填寒止血材料，安全且耐受性好，减轻了病人的痛苦，提高了治疗效果，得到了病人和医生的一致认可。     

基于工业设计的康复代步器分析及规划探讨

目的：中国永久或暂时性需要代步辅助的人群数量居世界首位，康复代步器对于这些人群的身体恢复、生活质量乃至精神状态都具有非常重要的积极意义。通过深入调研分析，从国内的实际情况出发，探讨了康复代步器领域的发展规划，具有实际指导价值。资料来源：上海市残联、上海轮椅厂提供的最新第一手基础数据资料。同时计算机检索IEL数据库1997-01／2005-05期间的文章，检索词为“Rehabilitation Devices，Wheelchair”，限定文章语言种类为English；检索中国期刊全文数据库、万方数据1997-01／2005-05期间的相关文章，检索词为“康复器械，轮椅”，限定文章语言种类为中文。资料选择：对资料进行初审，选取符合研究要求的有关文章，并开始查找全文。纳入标准：①国内外新型康复代步器械的研究。②有关中国残障需求情况的研究。排除标准：①陈旧的资料。②重复研究。资料提炼：共收集到297篇有关康复器械、轮椅及残障需求分析的文章，其中23篇符合研究要求。资料综合：①国内代步辅助需求调研：由于先天残疾、事故、疾病或者高龄等原因，我国需要轮椅的人数超过1500万，位居全球各国的首位，其中肢体残疾人数为1122万：约占总数的3／4。②国外康复代步器研究：西班牙研制的SIAMO智能轮椅采用呼吸实时驱动；日本革新的能够上下楼梯的康复代步器；美国开发的拥有3种运动模式的六轮自平衡康复代步器。③康复代步器领域展望：提供更多尺寸、更多品种、更多功能、更多档次的康复代步器。结论：依据“以人为本”的工业设计理念，分析和比较了国内外康复代步器的发展情况，由国内实际情况出发，提出在充分调研和建立残障人士基础数据库的平台上，运用以模块化为核心的数字设计制造技术，走出一条自主的设计制造的系列化、通用化、集约化康复代步器发展之路。     

健康和病变人声带振动特性声门图

本文用多功能声门图仪测定了健康受试者(男46名,女34名)和不同喉病患者(男134名,女87名)声门图的波形及其特征参数。根据测出的正常声门图及其参数分布研究了恶性喉病变、声带麻痹、喉内关节病变、功能性声门发声障碍、声带息肉、声带小结、喉炎和早期喉病的临床声门图表现及其与声带振动模式变异之间的关系,并探讨了上述病变声门图的鉴别诊断指标和用声门图对喉病手术治疗、药物治疗和功能治疗的疗效进行定性和定量评价。研究结果证实:声门图方法能准确、定量、灵敏地反映声带振动模式及其变异;在喉病诊治中具有重要的应用价值。     

Controlled release of antiseptic drug from poly(3-hydroxybutyrate)-based membranes. combination of diffusion and kinetic mechanisms

A polymeric system based on biocompatible and biodegradable poly(3-hydroxybutyrate) (PHB) is proposed for controlled release of furacilin (Frc). The kinetics of Frc release from PHB membranes containing 0.5–5.0 wt% Frc into a model aqueous medium at 25°C have been studied using a UV spectroscopy technique. The drug release profiles present a combination of diffusion and kinetic components. The diffusion component of the release kinetics has been analyzed and the dependence of the diffusivity on the drug concentrations has been determined. The rate constant of the release kinetics depends on the Frc concentration and is related to the hydrolytic destruction of PHB. The PHB hydrolysis is most clearly demonstrated in long-term experiments (after the first week of drug release). The obtained results are useful for the development of new controlled drug delivery systems containing several drugs, which provide a combined action on tissues and organs of the organism. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 12, pp. 30–33, December, 2007.     

Nucleotide changes around the splicing acceptor of intron 24 in the factor VIII gene and its impact on splicing.

Nucleotide 6724 of the factor VIII gene harbors a polymorphism of low frequency. A report from Taiwan claimed that 97.9% of the 83 alleles examined were of the A nucleotide at this position, which is quite different to the data from Western populations. Furthermore, this nucleotide is the start of exon 25, located in juxtaposition to the splicing acceptor of intron 24. We wonder if the nucleotide change at this location might have any effect on the splicing process of pre-mRNA. Using genomic DNA with direct sequencing of the polymerase chain reaction-amplified intron 24/exon 25 junction site, we found that 59 of the 60 patient samples were of the GTG sequence at nucleotides 6724-6726. The polymorphism is similar between populations in Taiwan and Western countries. The sequence of intron 24 around the splicing acceptor was always TCCAACTCTATTGCCCTCAG (-20 to -1), except for one hemophiliac patient who had a mutation in which the absolute consensus AG doublet of the intron 24 splicing acceptor changed to the AA dinucleotide. Owing to the mutation, exon 24 was erroneously spliced to exon 26, and exon 25 was skipped. This finding further testifies to the importance of the invariant AG dinucleotide in the example of the factor VIII gene.