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31.
Brian E. Dixon Jamie Pina Hadi Kharrazi Fardad Gharghabi Janise Richards 《Online Journal of Public Health Informatics》2015,7(2)
Objective: To categorize and describe the public health informatics (PHI) and
global health informatics (GHI) literature between 2012 and 2014.Methods: We conducted a semi-systematic review of articles published between
January 2012 and September 2014 where information and communications
technologies (ICT) was a primary subject of the study or a main component of the
study methodology. Additional inclusion and exclusion criteria were used to
filter PHI and GHI articles from the larger biomedical informatics domain.
Articles were identified using MEDLINE as well as personal bibliographies from
members of the American Medical Informatics Association PHI and GHI working
groups.Results: A total of 85 PHI articles and 282 GHI articles were identified. While
systems in PHI continue to support surveillance activities, we identified a
shift towards support for prevention, environmental health, and public health
care services. Furthermore, articles from the U.S. reveal a shift towards PHI
applications at state and local levels. GHI articles focused on telemedicine,
mHealth and eHealth applications. The development of adequate
infrastructure to support ICT remains a challenge, although we identified a
small but growing set of articles that measure the impact of ICT on clinical
outcomes.Discussion: There is evidence of growth with respect to both implementation of
information systems within the public health enterprise as well as a widening of
scope within each informatics discipline. Yet the articles also illuminate the
need for more primary research studies on what works and what does not as both
searches yielded small numbers of primary, empirical articles.Conclusion: While the body of knowledge around PHI and GHI continues to mature,
additional studies of higher quality are needed to generate the robust evidence
base needed to support continued investment in ICT by governmental health
agencies. 相似文献
32.
Eskandarifard Ebrahim Silva Rui Nobari Hadi Clemente Filipe Manuel Pérez-Gómez Jorge Figueiredo António José 《Sport Sciences for Health》2022,18(2):297-305
Sport Sciences for Health - The purposes of this study were to describe the fitness and hormonal levels according to playing time (PT) (i.e., PT during season less (PT1) or more (PT2) than 50% of... 相似文献
33.
NicholasA. Clanton Shayne D. Hastings Griffin B. Foultz Julie A. Contreras Samantha S. Yee Hadi D. Arman April L. Risinger Doug E. Frantz 《ACS medicinal chemistry letters》2020,11(12):2534
Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic steroids inspired by the naturally occurring taccalonolides. We demonstrate that these simplified analogs exhibit highly persistent antiproliferative properties similar to the taccalonolides and retain activity against resistant cancer cell lines that warrants further preclinical development. 相似文献
34.
Mohammad Taherdangkoo Mohammad Hadi Bagheri Mehran Yazdi Katherine P. Andriole 《Journal of digital imaging》2013,26(6):1116-1123
Since segmentation of magnetic resonance images is one of the most important initial steps in brain magnetic resonance image processing, success in this part has a great influence on the quality of outcomes of subsequent steps. In the past few decades, numerous methods have been introduced for classification of such images, but typically they perform well only on a specific subset of images, do not generalize well to other image sets, and have poor computational performance. In this study, we provided a method for segmentation of magnetic resonance images of the brain that despite its simplicity has a high accuracy. We compare the performance of our proposed algorithm with similar evolutionary algorithms on a pixel-by-pixel basis. Our algorithm is tested across varying sets of magnetic resonance images and demonstrates high speed and accuracy. It should be noted that in initial steps, the algorithm is computationally intensive requiring a large number of calculations; however, in subsequent steps of the search process, the number is reduced with the segmentation focused only in the target area. 相似文献
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38.
Mohamadnejad M Pourshams A Malekzadeh R Mohamadkhani A Rajabiani A Asgari AA Alimohamadi SM Razjooyan H Mamar-Abadi M 《World journal of gastroenterology : WJG》2003,9(10):2322-2324
AIM: The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1,939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels. RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L, and for non-overweight men was 40 U/L. CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately. 相似文献
39.
Mehdi Mohamadnejad Akram Pourshams Reza Malekzadeh Ashraf Mohamadkhani Afsaneh Rajabiani Ali Ali Asgari Seyed Meysam Alimohamadi Hadi Razjooyan Mamar-Abadi 《World journal of gastroenterology : WJG》2003,9(10)
AIM:The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors.METHODS: A total of 1 939 blood donors were included.ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L,and for non-overweight men was 40 U/L.CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately. 相似文献
40.
OBJECTIVE: The purpose of this double-blind, placebo-controlled study was to evaluate the safety, clinical efficacy and tolerability of imiquimod (2%) in cream to cure external genital warts in males. METHODS: Preselected male patients (n=60) ranging between 18 and 50 years of age (mean 24.2) harbouring 558 lesions (mean 9.3) with clinical, histopathological and polymerase chain reaction (PCR) confirmed diagnosis of human papilloma virus (HPV) infection were randomized to two parallel groups. Each patient was allocated a precoded 25g tube, and instructions on how to apply the trial medication to their lesions at home once daily for three consecutive days per week (max. 12 application in 4 weeks). To evaluate the safety, clinical efficacy and tolerance, patients were exa-mined on a weekly basis. Cure was defined as the total elimination of treated warts with PCR, and Southern blot hybridization confirmed negative HPV DNA. RESULTS: By the end of the treatment, 40% (24/60) patients and 49.8% (278/558) warts were cured. Breaking the code revealed that imiquimod cream had cured 70% (21/30) patients and 86.8% of warts, while placebo healed three subjects and 28 warts (P=0.0001). Eleven patients (18.3%), predominantly in the imiquimod cream group, experienced mild to moderate, non-objective, drug-related side effects with no dropouts. The study was followed up for 18 months from the first day of the treatment, and among the 26 cured patients, one in the imiquimod cream group and two in the placebo had a relapse after 14 months. CONCLUSION: The study demonstrated that 2% imiquimod in cream with mild non-objective side effects is safe, tolerable and significantly more effective than placebo in curing external genital warts in males. 相似文献