儿科3.0 T专用磁共振对早产儿脑损伤图像质量评价研究

目的 比较3.0 T儿科专用磁共振和3.0 T全身磁共振评估早产儿脑部图像质量,以评估3.0 T儿科专用磁共振在早产儿脑部成像的应用价值。材料与方法 本研究分别在3.0 T儿科专用磁共振和3.0 T全身磁共振进行颅脑成像扫描,采集序列包括常规序列和扩散加权成像(diffusion weighted imaging,DWI)序列,并对两组T2加权成像序列进行主观评分,对3D T1加权成像序列信噪比(signal-to-noise ratio, SNR)、对比噪声比(contrast-to-noise ratio, CNR)和DWI的表观扩散系数(apparent diffusion coefficient,ADC)值进行测量。结果 主观评分显示,3.0 T儿科专用磁共振图像质量与3.0 T全身磁共振评分相当,达到临床诊断需求。儿科专用磁共振图像的双侧额叶、顶叶、颞叶、枕叶灰质和白质,中脑,小脑SNR与全身磁共振图像差异无统计学意义(P>0.05),CNR相当或优于全身磁共振;双侧额叶、顶叶、颞叶、枕叶ADC值与全身磁共振图像差异无统计学意义(P>0.05)。结论 3.0 T儿...     

Pre-attack and pre-episode symptoms in cluster headache: a multicenter cross-sectional study of 327 Chinese patients

BackgroundThere have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study was to identify the prevalence and features of PAS and PES in Chinese patients, as well as to investigate their relationships with pertinent factors.MethodsThe study included patients who visited a tertiary headache center and nine other headache clinics between January 2019 and September 2021. A questionnaire was used to collect general data and information about PAS and PES.ResultsAmong the 327 patients who met the CH criteria (International Classification of Headache Disorders, 3rd edition), 269 (82.3%) patients experienced at least one PAS. The most common PAS were head and facial discomfort (74.4%). Multivariable logistic regression analysis depicted that the number of triggers (OR = 1.798, p = 0.001), and smoking history (OR = 2.067, p = 0.026) were correlated with increased odds of PAS. In total, 68 (20.8%) patients had PES. The most common symptoms were head and facial discomfort (23, 33.8%). Multivariable logistic regression analysis showed that the number of triggers were associated with increased odds of PES (OR = 1.372, p = 0.005).ConclusionsPAS are quite common in CH patients, demonstrating that CH attacks are not comprised of a pain phase alone; investigations of PAS and PES could help researchers better understand the pathophysiology of CH.     

严重创伤后氧对T细胞功能的影响

目的 探讨严重创伤后病人T淋巴细胞转化活性及CD4 T、CD8 T细胞活性变化,CTLA-4分子水平在严重创伤转归、干预治疗等方面的意义.方法 将133例病人分为创伤对照组46例、高流量吸氧组44例、高压氧组43例,创伤对照组患者入院后给予常规治疗;高流量吸氧组患者辅以5 L/min,120 min/d吸氧治疗;高压氧组患者辅以高压氧治疗(压力2 ATA,60 min/d).于3、7 d时间点,对各组分别进行T淋巴细胞转化活性、T淋巴细胞亚群及CTLA-4分子水平的测定.结果 与创伤对照组比较,高流量吸氧组和高压氧组患者的T淋巴细胞转化活性增高,CD4 T细胞数明显增多(P＜0.01),CD4 /CD8 细胞比值明显增加(P＜0.01),T细胞表面和总CTLA-4分子表达明显降低(P＜0.01);与高流量吸氧组相比,高压氧组患者的T淋巴细胞转化活性增高,CD4 T细胞数明显增多(P＜0.05),CD4 /CD8 细胞比值明显增加(P＜0.01),T细胞表面和总CTLA-4分子表达降低(P＜0.05).结论 氧能够明显提高T淋巴细胞转化活性,使CD4 T细胞增多,CD4 /CD8 细胞比值明显增加,并且明显降低T细胞表面和总CTLA-4分子的表达.     

IABP救治心脏手术后低心排血量的疗效观察

目的：评价主动脉内球囊反捕（ＩＡＢＰ）在心脏手术后不许治低心排血量（低心排）的效果。方法：２８例术后应用中等剂量心脏活性药物支持不能改善的低心排患,均立即使用ＫＡＡＴⅡＰｌｕｓ ＩＡＢＰ（４０ｍｌ）。监 桡动脉和主动脉压力波形,持续监测左心功能,记录尿量,观察末梢循环状况。结果：全组患ＩＡＢＰ辅助时间为（４８±３２）ｈ,早期生存率为７５．０％。所有患在应用ＩＡＢＰ后,桡动脉压力（基础收缩压）     

75名大学生双眼视机能的调查与分析

目的：探讨人眼屈光状态及双眼视机能的情况。方法：随机抽取75名在校大学生(男：34名，女：41名)，平均年龄21岁，进行问诊、屈光检查和双眼视机能检查，运用Morgan表、shcard准则、percival准则和1：1法则分别对远近分离性隐斜、远近辐辏、正融像性集合、负融像性集合、辐辏近点、调节幅度等参数进行评价。结果：低度近视24例，占32％；中度近视26例，占34．67％；高度近视8例，占10．67％；屈光参差4例，占5．33％；AC／A值，正常49例，占65％；高24例，占32％；低2例，占3％；基本外斜1例，占1．33％；集合不足5例，占6．67％；集合过度5例，占6．67％；散开不足2例，占2．67％；散开过度1例占1．33％，拥有正常双眼视机能占81．33％。结论：屈光不正患者中存在双眼视机能异常的占一定的比例。广泛地开展全面的、科学的视机能检查是十分必要的。     

血小板膜GPⅢa受体的基因多态性与阿司匹林在冠心病患者中疗效的关系

目的 探讨湖南地区部分人群中血小板膜糖蛋白GPⅢa基因的多态性与阿司匹林在冠心病患者中疗效的关系。方法 运用聚合酶链反应-限制性片断长度多态性分析(PCR-RELP)技术检测160例冠心病患者的GPPⅢa受体T1565C的基因多态性。结果 160例冠心病患者中,101例为野生型T/T(63.1％),42例为杂合子T/C(26.3％),17例为纯合子C/C(10.6％)。携带等位基因C的患者对服用阿司匹林后的闭塞时间较携带等位基因T的患者延长。结论 GPⅢa受体T1565C的基因多态性与阿司匹林的药物疗效密切相关,野生型T/T的患者出现高血小板聚集活性的几率显著增加。     

康艾注射液治疗化疗后白细胞减少症临床研究

目的:观察康艾注射液注射液治疗恶性肿瘤化疗后白细胞减少症的临床疗效。方法:收集石家庄市中医院肿瘤科住院患者共计115例,随机分为治疗组58例和对照组57例,对照组给予地榆升白片联合利可君升白治疗,治疗组用康艾注射液60 m L溶于质量分数5%葡萄糖溶液或生理盐水250 m L中静脉滴注,观察两组患者白细胞、中医证候、卡氏评分变化情况,评价临床疗效。结果:治疗组在改善患者中医证侯、提高卡氏评分及临床疗效方面有明显优势,与对照组比较,差异有统计学意义(P0.05);在升高白细胞方面,与对照组比较,差异无统计学意义(P0.05)。结论:康艾注射液对化疗后白细胞减少症有较好疗效,且能够明显改善患者临床症状,提高患者生存质量。     

Cumulative Recurrence Rate and Risk Factors for Recurrent Abdominal Wall Endometriosis after Surgical Treatment in a Single Institution

PurposeThis study aimed to evaluate the cumulative recurrence rate and risk factors for recurrent abdominal wall endometriosis (AWE) after surgical treatment.Materials and MethodsA retrospective cohort study was conducted at a single gynecological surgery center between January 2004 and December 2020. Patients who were surgically treated and followed up for at least 6 months after surgery were selected.ResultsEighteen patients with pathologically diagnosed AWE were included in this study. The median follow-up duration was 22.5 months (range, 6–106). The median age was 37 years (range, 22–48), and 33.3% of the patients were nulliparous. Among the patients included in our study, 55.6% complained of a mass with cyclic pain, and 27.8% had a palpable mass. In addition, 22.2% of patients experienced recurrence with 17.5±9.7 months of mean time to recurrence. The cumulative recurrence rates at 24 and 60 months after surgical treatment of AWE were 23.8% and 39.1%, respectively. There were no statistically significant risk factors for the recurrence of AWE, including postoperative medical treatment.ConclusionThe recurrence rate of AWE appears to be correlated with the follow-up duration. There was no statistically significant risk factor for the recurrence of AWE. Unlike ovarian endometriosis, postoperative hormonal treatment does not seem to lower the recurrence of AWE. The findings of the current study may help healthcare providers in counselling and managing patients with AWE.