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71.
TAKAYUKI TSUNEDA M.D. Ph .D. † TAKESHI YAMASHITA M.D. Ph .D.† TAKESHI KATO M.D. Ph .D.† AKIKO SEKIGUCHI Ph .D.† KOUICHI SAGARA M.D. † HITOSHI SAWADA M.D. † TADANORI AIZAWA M.D. † LONG-TAI FU M.D. Ph .D.† AKIRA FUJIKI M.D. Ph .D. HIROSHI INOUE M.D. Ph .D. 《Journal of cardiovascular electrophysiology》2009,20(9):1055-1060
Background: Since the prevalence of atrial fibrillation (AF) increases progressively with aging, especially in men, we hypothesized that testosterone might affect the occurrence of AF.
Methods and Results: We examined the electrophysiological properties of the atria in isolated-perfused hearts of sham-operated male (SM), female (SF), orchiectomized male with and without administration of testosterone (ORCH-T and ORCH), and ovariectomized female (OVX) Sprague-Dawley rats. An electrophysiological study revealed that repetitive atrial responses induced by electrical stimuli significantly increased in ORCH rats without changes in other electrophysiological properties and were abolished by administration of testosterone. To investigate the underlying mechanisms, we evaluated the expression level of calcium-handling proteins. In ORCH rats, the immunoreactive protein level of ryanodine receptor type 2 (RyR2) and sodium–calcium exchanger significantly increased as compared with SM and ORCH-T rats without alterations in the level of FK506-binding protein (FKBP12.6), sarcoendoplasmic reticulum Ca-ATPase, and phospholamban. Immunoprecipitation analysis demonstrated decreased binding of FKBP12.6 to RyR2 in ORCH rats, which was prevented by testosterone. In contrast, the expression levels of these proteins showed no significant differences between SF and OVX rats.
Conclusion: Deficiency of testosterone was arrhythmogenic in rat atria possibly through less binding of FKBP12.6 to RyR2, which could induce feasible calcium leakage from the sarcoendoplasmic reticulum. These results would explain, at least in part, the increase in the prevalence of AF in accordance with the decline of testosterone particularly in elderly men. 相似文献
Methods and Results: We examined the electrophysiological properties of the atria in isolated-perfused hearts of sham-operated male (SM), female (SF), orchiectomized male with and without administration of testosterone (ORCH-T and ORCH), and ovariectomized female (OVX) Sprague-Dawley rats. An electrophysiological study revealed that repetitive atrial responses induced by electrical stimuli significantly increased in ORCH rats without changes in other electrophysiological properties and were abolished by administration of testosterone. To investigate the underlying mechanisms, we evaluated the expression level of calcium-handling proteins. In ORCH rats, the immunoreactive protein level of ryanodine receptor type 2 (RyR2) and sodium–calcium exchanger significantly increased as compared with SM and ORCH-T rats without alterations in the level of FK506-binding protein (FKBP12.6), sarcoendoplasmic reticulum Ca-ATPase, and phospholamban. Immunoprecipitation analysis demonstrated decreased binding of FKBP12.6 to RyR2 in ORCH rats, which was prevented by testosterone. In contrast, the expression levels of these proteins showed no significant differences between SF and OVX rats.
Conclusion: Deficiency of testosterone was arrhythmogenic in rat atria possibly through less binding of FKBP12.6 to RyR2, which could induce feasible calcium leakage from the sarcoendoplasmic reticulum. These results would explain, at least in part, the increase in the prevalence of AF in accordance with the decline of testosterone particularly in elderly men. 相似文献
72.
Concealed Accessory Pathways with a Single Ventricular and Two Discrete Atrial Insertion Sites 下载免费PDF全文
RYAN T. KIPP M.D. RAED ABU SHAM'A M.D. ITO HIROYUKI M.D. FREDERICK T. HAN M.D. MARWAN REFAAT M.D. Ph.D. JONATHAN C. HSU M.D. M.A.S. MICHAEL E. FIELD M.D. DOUGLAS E. KOPP M.D. GREGORY M. MARCUS M.D. M.A.S. MELVIN M. SCHEINMAN M.D. KURT S. HOFFMAYER M.D. 《Pacing and clinical electrophysiology : PACE》2017,40(3):255-263
73.
TETSUO ARAKAWA HAJIME NAKAMURA HIROSHI SATOH TAKASHI FUKUDA HIROYUKI SAKUMA KENZO KOBOYASHI 《Journal of gastroenterology and hepatology》1988,3(5):441-449
The levels of prostaglandin E2 (PGE2 ), 6-keto-prostaglandin F1 α (PGF1 α) and thromboxane B2 (TXB2 ) in endoscopic biopsy specimens from the gastric and duodenal mucosa of healthy volunteers and ulcer patients were measured by radio-immunoassay. The PGE2 and PGF1 α levels in the mucosa of the corpus of the stomach were lower and the TXB2 level was higher in 10 patients with gastric ulcer in the corpus than in the 16 healthy subjects. The PGE2 level in the antral mucosa of 14 patients with gastric ulcer in the antrum was lower than in the controls. In 18 patients with duodenal ulcer, PGE2 deficiency was more widespread in the entire gastric and duodenal mucosa while the reduced PGF1 α level was limited in the gastric corpus. Lower levels of PGE2 in patients with antral or duodenal ulcer and of PGE2 and PGF1 α in patients with corpus ulcer in the anatomical mucosal area including the ulcer site may predispose the mucosa to ulceration. 相似文献
74.
Impact of Non‐Pulmonary Vein Foci on the Outcome of the Second Session of Catheter Ablation for Paroxysmal Atrial Fibrillation 下载免费PDF全文
MASATERU TAKIGAWA M.D. ATSUSHI TAKAHASHI M.D. TAISHI KUWAHARA M.D. KENJI OKUBO M.D. YOSHIHIDE TAKAHASHI M.D. EMIKO NAKASHIMA M.D. YUJI WATARI M.D. KAZUYA YAMAO M.D. JUN NAKAJIMA M.D. KATSUMASA TAKAGI M.D. SHIGEKI KIMURA M.D. HIROYUKI HIKITA M.D. KENZO HIRAO M.D. MITSUAKI ISOBE M.D. 《Journal of cardiovascular electrophysiology》2015,26(7):739-746
75.
76.
Clonal and non-clonal karyotypically abnormal cells in haemophagocytic lymphohistiocytosis 总被引:1,自引:0,他引:1
YASUHIKO KANEKO NOBUO MASEKI MASAHARU SAKURAI MASARU IDO YUKIKO TSDNEMATSU SHUKI MIZUTANI TATSUYA HATTORI HIROYUKI SHIMIZU HARUHIKO EGUCHI TOSHIAKI OKA MUNENORI MIYAKE YASUO HORIKOSHI TAIZAN SUCHI 《British journal of haematology》1995,90(1):48-55
We studied chromosomes in bone marrow (BM) or peripheral blood cells of nine patients with haemophagocytic lymphohistiocytosis (HLH); three of them had a family history of HLH and four others underwent concurrent Epstein-Barr virus (EBV) infection. In addition to a large population of normal mitotic cells, karyotypically abnormal clonal cells were found in two patients, abnormal clonal cells and a nonclonal (single) abnormal cell in one, and nonclonal abnormal cells in three. All the six patients with chromosome abnormalities died of progressive disease; one of them also had EBV infection and EBV-associated clonal proliferation. Two of three patients with EBV infection and only normal mitotic cells in BM completely recovered from the disease.
Although HLH did not show histological and/or haema-tological evidence of a neoplastic disease, clonal chromosome abnormalities and the fatal clinical outcome found in some of the patients suggest that the disease may be heterogenous and include malignancy. HLH patients with karyotypically abnormal clonal cells in BM should warrant more intensive chemotherapy than that presently being applied to them and should be considered as candidates for BM transplantation. 相似文献
Although HLH did not show histological and/or haema-tological evidence of a neoplastic disease, clonal chromosome abnormalities and the fatal clinical outcome found in some of the patients suggest that the disease may be heterogenous and include malignancy. HLH patients with karyotypically abnormal clonal cells in BM should warrant more intensive chemotherapy than that presently being applied to them and should be considered as candidates for BM transplantation. 相似文献
77.
Class IC Antiarrhythmic Drugs, Flecainide and Pilsicainide, Produce ST Segment Elevation Simulating Inferior Myocardial Ischemia 总被引:1,自引:0,他引:1
WAKO NAKAMURA M.D. KAZUHIKO SEGAWA M.D. HIROYUKI ITO M.D. SHUGO TANAKA M.D. NOBUO YOSHIMOTO M.D. 《Journal of cardiovascular electrophysiology》1998,9(8):855-858
ST Elevation with Flecainide and Pilsicainide . Flecainide and pilsicainide, Class IC antiarrhythmic drugs with slow kinetics, were administered to a 64-year-old man experiencing ventricular tachycardia. Both drugs suppressed the arrhythmia, but caused ST segment elevation in leads II, III, and aVF. No evidence of ischemic heart disease was detected. Withdrawal of the drugs eliminated the ST change. Because these drugs frequently are used to treat tachyarrhythmias in patients who may present with chest pain, this rare ECG manifestation of Class IC drugs should he recognized to avoid misdiagnosis of acute interior myocardial infarction. 相似文献
78.
HIROYUKI FUJITA ATSUO MARUTA NAOTO TOMITA JUN TAGUCHI RIKA SAKAI AKIO SHIMIZU MASAOKI HARADA KOUJI OGAWA FUMIO KODAMA TAKAO OKUBO 《British journal of haematology》1995,92(4):947-949
We report the first case of human herpesvirus-6 (HHV-6) associated exanthema in a patient with acute lymphocytic leukaemia (ALL). We analysed DNA extracted from an exanthematous lesion using the polymerase chain reaction (PCR). DNA was positive for HHV-6 but negative for herpes simplex virus, varicella zoster virus, and cytomegalovirus. Immunohistochemical staining of the skin with monoclonal antibody against HHV-6 confirmed the infection. The possibility of HHV-6 infection should be considered when an atypical skin rash is seen in patients with ALL. 相似文献
79.
80.
AKIHIKO NOGAMI MOTOHIRO NAKAO SHOICHI KUBOTA AIKO SUGIYASU HIROSHI DOI KEN YOKOYAMA KAZUHIKO YUMOTO TOSHIYUKI TAMAKI KEN-ICHI KATO NORIYO HOSOKAWA† HIROSHI SAGAI† HIROYUKI NAKAMURA‡ JUN-ICHI NITTA‡ YASUTERU YAMAUCHI§ KAZUTAKA AONUMA§ 《Pacing and clinical electrophysiology : PACE》2003,26(1P2):332-337
NOGAMI, A., et al. : Enhancement of J–ST-Segment Elevation by the Glucose and Insulin Test in Brugada Syndrome. The effects of glucose and insulin on J–ST-segment elevation were evaluated in seven men (mean age 45 ± 10 years) with Brugada syndrome. Six patients had been reanimated from VF and one patient had experienced syncope. The effects of intravenous (1) pilsicainide 50 mg, (2) glucose 50 g, and (3) glucose 50 g plus regular insulin 10 IU on the precordial ECG leads were examined. Pilsicainide significantly enhanced J-ST elevation in all patients and induced VF in 1 patient. A significant accentuation of the abnormal J-ST configuration was observed in all patients at a mean of 51 ± 40 minutes after glucose and insulin infusion. Changes in blood glucose and serum potassium concentration were 111 ± 158 mg/dL and −0.30 ± 0.48 mEq/L , respectively. These changes were not directly related to the ECG changes. Glucose infusion without insulin caused a subtle increase in J-ST elevation. In conclusion, the administration of glucose and insulin safely unmasked or accentuation the J–ST-segment elevation in Brugada syndrome. Blood glucose and insulin concentrations may be factors modulating the circadian or day-to-day ECG variations in this syndrome. (PACE 2003; 26[Pt. II]:332–337) 相似文献