全文获取类型
收费全文 | 626篇 |
免费 | 18篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 86篇 |
妇产科学 | 6篇 |
基础医学 | 49篇 |
口腔科学 | 13篇 |
临床医学 | 38篇 |
内科学 | 161篇 |
皮肤病学 | 27篇 |
神经病学 | 46篇 |
特种医学 | 2篇 |
外科学 | 94篇 |
综合类 | 5篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 58篇 |
肿瘤学 | 46篇 |
出版年
2022年 | 5篇 |
2021年 | 7篇 |
2016年 | 5篇 |
2015年 | 16篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 7篇 |
2011年 | 7篇 |
2010年 | 10篇 |
2009年 | 10篇 |
2007年 | 17篇 |
2006年 | 39篇 |
2005年 | 11篇 |
2004年 | 20篇 |
2003年 | 14篇 |
2002年 | 10篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 9篇 |
1998年 | 30篇 |
1997年 | 38篇 |
1996年 | 48篇 |
1995年 | 44篇 |
1994年 | 21篇 |
1993年 | 28篇 |
1992年 | 20篇 |
1991年 | 9篇 |
1990年 | 11篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 10篇 |
1986年 | 12篇 |
1985年 | 18篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 3篇 |
1969年 | 3篇 |
1967年 | 2篇 |
1960年 | 2篇 |
1959年 | 2篇 |
1958年 | 15篇 |
1957年 | 15篇 |
1956年 | 13篇 |
1955年 | 10篇 |
1954年 | 9篇 |
1948年 | 2篇 |
排序方式: 共有644条查询结果,搜索用时 15 毫秒
641.
TADASHI IWAO ATSUSHI TOYONAGA HIROYUKI SHIGEMORI KAZUHIKO OHO MICHIHIRO SUMINO MASAHIRO SATO KYUICHI TANIKAWA 《Journal of gastroenterology and hepatology》1996,11(3):216-222
The effects of vasopressin plus oxygen and vasopressin alone on gastric mucosal perfusion and oxygenation were studied using reflectance spectrophotometry and laser Doppler velocimetry in 23 cirrhotic patients with portal-hypertensive gastropathy. The measurements were performed under basal conditions and after double-blinded administration of placebo (n= 7), vasopressin (0.3 U/min; n= 8) or vasopressin (0.3 U/min) plus nasal oxygen (4 L/min; n= 8). No significant effects on gastric mucosal haemodynamics and oxygenation were observed after placebo. In contrast, vasopressin and vasopressin plus oxygen induced a similar reduction in haemoglobin content (-26 ± 2 and -21 ± 4%, respectively P < 0.01) and laser Doppler signal (-23 ± 2 and -22 ± 2%, respectively, P < 0.01). Although each treatment induced a significant reduction in oxygen saturation (-21 ± 2 and -7 ± 1%, respectively P < 0.01), the effect was less pronounced in patients receiving the combination than in those receiving vasopressin alone (P < 0.01). These data suggest that vasopressin and vasopressin plus oxygen reduce gastric mucosal hyperaemia and that the oxygen supplement partially protects against gastric mucosal hypoxia during vasopressin infusion in cirrhotic patients with portal-hypertensive gastropathy. 相似文献
642.
643.
T. TERUI M. ROKUGO S. AIBA T. KATO H. TAGAMI 《The British journal of dermatology》1990,123(3):325-331
The autologous mixed lymphocyte reaction (auto-MLR) was studied to test the interactions between immunocompetent cells in patients with psoriasis. The auto-MLR in 20 patients with psoriasis was significantly lower than in 16 normal controls. Lower values were found in untreated psoriatic patients than in those in remission following treatment. The values in the latter group were significantly lower than in controls and in six patients with atopic dermatitis in remission. The tendency for an increase in the auto-MLR with a decrease in disease activity was further confirmed in five patients studied before and after treatment. In contrast, the allogeneic lymphocyte reaction (allo-MLR) in psoriatics was similar to that in normal controls. 相似文献
644.
H. OKOCHI M. KATO K. NASHIRO O. YOSHIE† K. MIYAZONO M. FURUE 《The British journal of dermatology》1997,137(6):856-863
Tetra-spans transmembrane family (TSTF) members (CD9, CD37, CD53, CD63, CD81 and CD82) have potent effects on cell growth, motility and adhesion in various cells. However, little is known about their expression in human skin. Using immunohistological techniques, we have studied the localization of all six members of TSTF in normal and carcinomatous human keratinocytes. CD9, CD81 and CD82 were expressed in the entire living layers of the epidermis. Their staining pattern was quite similar, and was mainly intercellular with occasional intracellular immunoreactivity. CD53 expression was confined to the intercellular spaces of the upper spinous or granular layer in the normal epidermis. No clear-cut expression of CD63 could be detected in the epidermis. CD37 was not detected at all. Cultured human keratinocytes also expressed CD9, CD81 and CD82 at the surface membrane of cell-cell boundaries. Expression of CD37 and CD53 was negative in cultured keratinocyte, while CD63 was clearly localized in the cytoplasmic lysosomes. An immunoprecipitation assay revealed that α3β1 integrin is molecularly associated with CD9. The expression of CD9, CD81 and CD82 was markedly down-regulated in basal cell carcinoma but not in Bowen's disease. The abundant and differential expression of TSTF molecules and the selective association of CD9 with α3β1 integrin suggest that the TSTF molecules may be involved in the regulation of epidermal differentiation and integrity in vivo. 相似文献