银杏外种皮化学成分研究

从银杏外种皮的乙酸乙酯、丙酮和正丁醇提取物中，分得８个结晶，经波谱解析，与对照品及标准图谱对照，分别鉴定为：胡萝卜甙（ｄａｕｃｏｓｔｅｒｏｌ，１）、银杏内酯Ａ和银杏内酯Ｂ混合物（ｇｉｎｋｇｏｌｉｄｅＡａｎｄＢ，２）、银杏内酯Ｃ（ｇｉｎｋｇｏｌｉｄｅＣ...     

肺血流图预测肺动脉压探讨

报告９７例慢性阻塞性肺疾病（ＣＯＰＤ）及慢性肺心病（ＣＣＰ）患者与右心导管对照评价肺阻抗血流图（ＩＰＲ）预测肺动脉平均压（ｍＰＡＰ）的意义。分析ＩＰＲ各单项参数与ｍＰＡＰ的相关性，提示ＩＰＲ主要参数Ｐ＿２－Ｙ间期，Ｂ－Ｙ间期及Ｑ－Ｂ／Ｂ－Ｙ与ｍＰＡＰ呈中度相关。建立ＩＰＲ预测ｍＰＡＰ多元回归方程式，ｒ＝０．７７４。结果提示ＩＰＲ可作为临床近似预测ＣＯＰＤ及ＣＣＰ患者ｍＰＡＰ的简便方法，但尚不能取代右心导管作出精确诊断。     

健康人加压素释放和渴感的渗透压阈值

报道１２名受试者在静滴５％ＮａＣｌ２ｈ（每分钟０．０６ｍｌ／ｋｇ）的过程中血钠、血渗、血浆精氨酸加压素（ＡＶＰ）浓度和渴感等级的变化。结果显示，血浆ＡＶＰ浓度及渴感等级分别与血渗呈线性相关，回归方程分别为：血浆ＡＶＰ浓度（ｐＡＶＰ）－０．２４［血浆渗透压（ｐＯｓｍ）－２７４］（ｒ＝０．７２，Ｐ＜０．００１）；渴感等级（Ｔｈ）＝０．２３（ｐＯｓｍ－２７９）（ｒ＝０．６２，Ｐ＜０．００１）．两者灵敏度及阈值均较国外文献报道的结果低，认为加压素释放及渴感的渗透压阈值可能与遗传因素及生活习俗有关，ＡＶＰ分泌及渴感的渗透压调节可能存在种族差异。     

高血压病,冠心病患者血浆内皮素水平及其临床意义初探

本文检测了原发性高血压和冠心病患者血浆内皮素水平，结果发现原发性高血压Ⅰ、Ⅱ期组和冠心病心功代偿组血浆ＥＴ值与正常对照组无著差异；高血压Ⅲ期组及冠心病心衰组血浆ＥＴ值明显高于正常对照组，１２例冠心病心衰患者治疗后血浆ＥＴ水平明显降低。提示ＥＴ参与了原发性高血压严重并发症及冠心病心衰的发生和发展。冠心病患者血浆ＥＴ浓度与心功不全程度有关；高血压病患者血浆ＥＴ浓度与血压高低无关。     

Relative distribution of Schistosoma japonicum eggs in the intestine of man: a subject of inconsistency.

The relative distribution of Schistosoma japonicum eggs in the intestine of man is inconsistent in the literature. Some scientists believe that the adult S. japonicum worms reside mainly in the superior mesenteric vein and their eggs are deposited predominately in the small intestine, whereas others have shown that the adult worms have a predilection for inhabiting the branches of the inferior mesenteric vein and superior haemorrhoidal vein and their eggs are deposited in much higher density in the large intestine, especially in the rectum, sigmoid and descending colon, than in the small intestine. A review of the literature was made which includes the results from animal experiments as well as from human clinical and pathological studies. The author is in favour of the latter view that in man, S. japonicum eggs are deposited predominately in the large intestine and small intestine involvement is usually slight.     

Fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. An atypical form of Epstein-Barr virus infection.

Ten cases of pediatric fulminant hemophagocytic syndrome, encountered between 1986 and 1989, are described. They occurred in the summer, and the patients presented with fever, jaundice, hepatosplenomegaly, pancytopenia, coagulopathy, and abnormal liver function. Bone marrow studies revealed infiltration by atypical T-lymphoid cells, rare B immunoblasts, and mature histiocytes with hemophagocytosis. Initially, histiocytic medullary reticulosis was suspected in six cases. The clinical course was characterized by rapid deterioration, with a mean period of 16 days from onset of fever to death. The main causes of death were coagulopathy with multiple organ failure and opportunistic infection. In seven of eight cases studied by serologic assay and Southern blot hybridization, acute or active Epstein-Barr virus (EBV) infection was documented. It is suggested that an atypical or fulminant form of primary EBV infection distinct from classic infectious mononucleosis was prevalent in previously healthy children in Taiwan. Younger age involvement and seasonal clustering were characteristic of the disorder described.     

糖尿病肾脏胶原非酶糖化与氨基胍阿斯匹林的治疗作用

本实验系统观察了ＳＴＺ所致糖尿病鼠在１、３、６个月后肾脏组织胶原发生非酶糖化的情况，及氨基胍、阿斯匹林对肾脏胶原非酶糖化的阻断作用。结果表明：各病程糖尿病动物肾组织的胶原含量和非酶糖化早期产物（５－ＨＭＦ）及胶原相联荧光值均明显高于正常对照。氨基胍能够减弱糖尿病动物肾组织胶原含量的增加和荧光产物的生成，但对５－ＨＭＦ含量无影响。阿斯匹林未显示出对胶原非酶糖化的影响。     

四肢带表浅静脉干的局部皮瓣在创伤修复中的应用

设计4种带表浅静脉干的局部皮瓣用于修复四肢创面14例,获得了满意的效果。该皮瓣所包含的一条浅静脉干,不仅有利于静脉回流,且其血流对皮瓣亦有营养作用。因此,该皮瓣容易成活,长宽比值可大于传统任意型皮瓣。并具有操作简便,不损伤主要动脉等优点。文中介绍了皮瓣的设计及手术方法,并对该皮瓣的血液循环特点、适应证及供区选择等进行了讨论。     

埃索美拉唑三联与奥美拉唑三联疗法治疗Hp阳性十二指肠溃疡对比研究

目的比较埃索美拉唑三联与奥美拉唑三联疗法治疗幽门螺杆菌（Hp）阳性十二指肠球部溃疡的临床疗效。方法将104例经内镜诊断并检测证实Hp阳性的十二指肠球部溃疡患者随机分为两组。埃索美拉唑组（52例）：埃索美托唑20mg＋阿莫西林1g＋克托霉素500mg，每日2次，共7d；奥美拉唑组（52例）：奥美拉唑20mg＋阿莫西林1g＋克拉霉素500mg，每日2次，共7d。疗程结束4周后复查胃镜并检测Hp，观察腹痛缓解率、溃疡愈合率、Hp根除率及用药后的不良反应等。结果埃索美拉唑组第1天和第2天腹痛缓解率分别为34．6％和59、6％，高于奥美托唑组的17.3％和38．5％（P〈0．05）。埃索美托唑组和奥美拉唑组溃疡愈合率分别为92.3％和88．5％，Hp根除率分别为88．5％和82．7％，差异无显著性（P〉0．05）。两组用药后不良反应少，有较好的安全性。结论埃索美拉唑三联疗法治疗Hp阳性的十二指肠溃疡安全有效．腹痛缓解速度优于奥美拉唑三联疗法。