Striatal dopamine metabolism in living monkeys examined by positron emission tomography

Positron emission tomography, using the dopa analogue [18F]6-fluoro-L-dopa, has been used to depict the neostriatum in living monkeys. The amount of 18F that accumulated preferentially in the striatum could be augmented by a peripheral decarboxylase inhibitor. Striatal 18F could also be discharged with reserpine. This is the first time that the regional distribution of a neurotransmitter has been demonstrated in monkeys.     

High myopia as an unusual cause of restrictive motility disturbance

Endocrine ophthalmopathy is a common cause of restrictive ocular motility disorder associated with abnormal forced duction testing. We report ultrasonographic and computed tomographic findings in a highly myopic patient without thyroid abnormality in whom the restrictive findings of endocrine ophthalmopathy were simulated by contact between elongated globes and the bones of the orbital apices.     

Karyotyping of Single Human Chromosomes from Dry Mass Determined by Electron Microscopy

Human chromosomes from cultures of peripheral lymphocytes were prepared for electron microscopy by surface spreading and critical-point drying. Total and partial determinations of chromosomal dry mass were made from contrast in electron microscopic negatives. The distribution of dry weights was analyzed with respect to the Denver-Chicago classifications. There is considerable variability of mass within each group, but no statistically significant differences between four donors. A single chromosome can be correctly classified from its total mass and the ratio of long- to short-arm mass.     

Topochemische Verteilung von K+, Na+, Mg++ und Ca++ im normalen Herzmuskel

Zusammenfassung Es wird der Versuch unternommen, ein topochemisches Verteilungsmuster der Elektrolyte K⁺, Na⁺, Mg⁺⁺ und Ca⁺⁺ im normalen menschlichen Herzmuskel aufzustellen. Dabei fanden sich statistisch gesicherte Abweichungen des Elektrolytgehaltes zwischen dem rechten und linken Myokard, während die Konzentrationsunterschiede innerhalb der Herzkammern gering waren und dem statistischen Prüfverfahren nicht standhielten.

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Topochemical distribution of K⁺, Na⁺, Mg⁺⁺ and Ca⁺⁺ in normal human myocardium

Summary An attempt was made to devise a topochemical pattern of distribution of electrolytes K⁺, Na⁺, Mg⁺⁺ and Ca⁺⁺ in the normal, human myocardium. Statistically significant deviations of the electrolyte content were found between the right and left myocardium, whereas the differences in concentration within the cardiac ventricles were small and did not stand statistical analysis.

     

Vitalhistologische Befunde an der menschlichen haut

Ohne Zusammenfassung     

Influence of tryptophan and related compounds on ergot alkaloid formation in Claviceps purpurea (Fr.) Tul.

L -Tryptophan did not exert any influence on peptide alkaloid formation in an ergotamine and in an ergosine-accumulating C. purpurea strain. A different picture was observed in a series of related C. purpurea strains. Tryptophan showed a slight stimulatory effect on the ergotoxine producer Pepty 695/S. A blocked mutant of it, designated as Pepty 695/ch which was able to accumulate secoclavines gave similar results. In a high-yielding elymoclavine strain Pepty 695/e, the progeny of the former one, tryptophan up to a concentration of 25 mm stimulated remarkably clavine biosynthesis. Furthermore, tryptophan could overcome the block of synthesis by inorganic phosphate. Increased specific activities of chanoclavine cyclase but not DMAT synthetase were observed in cultures of strain Pepty 695/e supplemented with tryptophan. 5-Methyltryptophan and bioisosteres of tryptophan were ineffective in alkaloid stimulation. These results are compared with those obtained with the grass ergot strain SD 58 and discussed with the relation to other induction phenomena.