EGFR、p53、Fascin蛋白在鼻咽癌组织中表达

目的探讨表皮生长因子受体(EGFR)、p53抑癌基因(p53)、肌成束蛋白(fascin)在鼻咽癌组织中的表达及意义, 为鼻咽癌不良预后的预测和改善提供依据。方法随机抽取2009年1月—2011年10月在郑州市人民医院耳鼻咽喉科住院的88例鼻咽癌患者, 采用免疫组化法检测患者鼻咽癌组织和癌旁正常组织中EGFR、p53和fascin表达水平, 分析EGFR、p53和fascin表达水平与患者临床病理特征和预后的关系。结果鼻咽癌组织中EGFR和fascin阳性表达率(82.95%和92.05%)均高于癌旁正常组织(10.23%和9.09%), p53阳性表达率(12.50%)低于癌旁正常组织(88.64%), 差异均有统计学意义(均P<0.001)。结论EGFR和fascin蛋白在鼻咽癌组织中的阳性表达率较高而p53蛋白阳性表达率较低, 3种蛋白均与鼻咽癌临床病理特征和预后情况相关。     

ZDHHC9 promotes colon tumor growth by inhibiting effector T cells

Zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9) has been reported to play an important role in the occurrence and development of several types of cancer. However, its effects on colon cancer growth remain unclear. Using Gene Expression Profiling Interactive Analysis and Tumor Immune Estimation Resource, data obtained from The Cancer Genome Atlas were analyzed, and the results showed that ZDHHC9 was highly expressed in colon cancer and that patients with higher ZDHHC9 expression levels had a worse prognosis. Inhibition of ZDHHC9 expression promoted the proliferation of colon cancer cells in vitro but decreased their growth in vivo. Additionally, inhibition of ZDHHC9 expression in cancer cells enhanced CD8⁺ T cell-mediated cytotoxicity in vitro and increased CD8⁺ T infiltration and activation in vivo. Furthermore, ZDHHC9 promoted IFN-γ-induced JAK/STAT1 activation and upregulated programmed death-ligand 1 (PD-L1) expression in colon cancer cells. In conclusion, the present findings showed that ZDHHC9 promoted colon cancer growth by upregulating the expression of PD-L1 and inhibiting the function of CD8⁺ T cells.     

Experimental Study on Mechanical Properties and Failure Laws of Granite with Artificial Flaws under Coupled Static and Dynamic Loads

Rock is the main construction material of rock engineering, such as the engineering of mines and tunnels; in addition, its mechanical properties and failure laws are of great significance to the stability evaluation of rock engineering, especially under the conditions of coupled static–static stresses. In this study, granite specimens were manufactured with artificial flaws. Coupled static and dynamic loads tests were carried out with a modified split Hopkinson pressure bar (SHPB) apparatus; and six typical levels of axial pre-stresses and three crack inclination angles were designed. Three-dimensional digital image correlation (3D-DIC) was also applied to record and analyze the fracturing process and damage evolution of the specimens. The test results show that there was no compaction stage in the stress–strain curve under combined dynamic and static loading. The dynamic strength of the specimens increased first and then decreased with the increase in the static pressure; moreover, the specimens reached the maximum dynamic strength when the static pressure was 10% UCS. The dynamic strength decreased first and then increased with the increase in the crack inclination angle; and the lowest strength appeared when the inclination angle was 45°. The change in axial compression had a significant influence on the failure mode, and the failure mode gradually transformed from shear–tensile failure to shear failure with the increase in the pre-stress. The tensile strain was usually generated at the end of the fractures or near the rock bridge. When the axial pressure was small, the tensile strain zone parallel to the loading direction was easily generated; and when the axial pressure was large, a shear strain zone developed, extending along the diagonal direction. The research results can provide a theoretical reference for the correct understanding of the failure mechanisms of granite and its engineering stability under actual conditions.     

Genetic Algorithm-Assisted Design of Sandwiched One-Dimensional Photonic Crystals for Efficient Fluorescence Enhancement of 3.18-μm-Thick Layer of the Fluorescent Solution

One-dimensional photonic crystal structures have been widely used to enhance fluorescence. However, its fluorescence enhancement is low-fold because of a weak excitation field region. In this paper, we used a genetic algorithm to assist in the design of two photonic crystals based on Al₂O₃ and TiO₂ materials. One of them has a defect consisting of SiO₂. The Fabry-Perot cavity (FP cavity) formed by the sandwiched photonic crystal achieves up to 14-fold enhancement of the excitation electric field. We modulate the electric field radiation distribution of the fluorescent material by using photonic forbidden bands. For a 3.18 μm thick layer of the fluorescent solution, the structure achieves up to 60-fold fluorescence enhancement. We also discussed that the reason for the different enhancement abilities in different places is the phase change caused by the optical path difference. This design is expected to have applications in display, imaging, etc.     

细胞周期相关激酶的肿瘤机制

细胞周期相关激酶(CCRK)作为一种新发现的细胞周期依赖激酶活化激酶,主要参与细胞周期的调控.相关研究证实CCRK在多种肿瘤细胞中均有过表达,且与患者不良预后密切相关,提示CCRK参与了肿瘤的发生发展过程.     

当代中国民族出版业的作用与意义

民族出版业是党的宣传工作重要一环。本文深刻地探讨了中国民族出版业的作用,以及重要的现实意义和深远的历史意义。     

肾炎宁胶囊治疗慢性肾炎的临床对照研究

目的 探讨肾炎宁胶囊治疗慢性肾炎的临床疗效和安全性.方法 筛选慢性肾炎患者75例,分为试验组和对照组,试验组39例,对照组36例.试验组给予肾炎宁胶囊治疗,对照组给予肾炎四味胶囊治疗.12周为一个疗程,两组均治疗12周后比较两组临床疗效.结果 治疗12周后,试验组治疗总有效35例,总有效率为89.7％,对照组治疗总有效...     

中国流感疫苗预防接种技术指南(2021 — 2022)

流行性感冒（简称流感）与新型冠状病毒肺炎（简称新冠肺炎）均为呼吸道传染病,若二者合并感染,不但会加重病情、延长病程,且会使死亡率升高,特别是对老年人、儿童及慢性病人群风险更大,同时还会给患者个人、家庭及社会带来沉重的疾病经济负担。因此,在全球新冠肺炎大流行背景下,加强对流感的防控具有重要的现实意义。本文从中国流感防控现状和长期目标及新冠肺炎疫情防控背景下流感防控的新形势和新要求2个方面概述目前中国流感疾病负担、问题与挑战,并提出相关流感防控的应对策略。     

Hypertension and stroke in Asia: A comprehensive review from HOPE Asia

Stroke is the primary cause of disability and vascular death worldwide, including Asia. Asian characteristics that differ from the West lead to higher stroke incidence. Stroke epidemiology studies in Asia have shown varying levels of mortality, incidence, prevalence, and burden of disease. Hypertension is the most prevalent risk factor found in Asia. Besides ethnicity that is associated with stroke incidence, both systolic blood pressure, diastolic blood pressure, and blood pressure variability are positively correlated with stroke incidence. Post‐stroke cognitive impairment is one of the sequelae that affect one‐third of stroke survivors and has become a significant public health concern that is often neglected despite its increasing prevalence. Therefore, it is very important to prevent recurrence by treating stroke optimally and effectively. Increasing awareness and treatment adherence to hypertension, the leading risk factor for stroke, became the main goal in several countries in Asia.