全文获取类型
收费全文 | 728篇 |
免费 | 42篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 41篇 |
妇产科学 | 27篇 |
基础医学 | 118篇 |
口腔科学 | 6篇 |
临床医学 | 60篇 |
内科学 | 130篇 |
皮肤病学 | 8篇 |
神经病学 | 37篇 |
特种医学 | 97篇 |
外科学 | 68篇 |
综合类 | 34篇 |
预防医学 | 45篇 |
眼科学 | 1篇 |
药学 | 42篇 |
中国医学 | 3篇 |
肿瘤学 | 52篇 |
出版年
2023年 | 2篇 |
2022年 | 7篇 |
2021年 | 17篇 |
2020年 | 7篇 |
2019年 | 17篇 |
2018年 | 21篇 |
2017年 | 10篇 |
2016年 | 10篇 |
2015年 | 10篇 |
2014年 | 29篇 |
2013年 | 36篇 |
2012年 | 31篇 |
2011年 | 38篇 |
2010年 | 32篇 |
2009年 | 27篇 |
2008年 | 26篇 |
2007年 | 25篇 |
2006年 | 35篇 |
2005年 | 31篇 |
2004年 | 31篇 |
2003年 | 41篇 |
2002年 | 25篇 |
2001年 | 13篇 |
2000年 | 16篇 |
1999年 | 8篇 |
1998年 | 26篇 |
1997年 | 29篇 |
1996年 | 17篇 |
1995年 | 14篇 |
1994年 | 21篇 |
1993年 | 12篇 |
1992年 | 13篇 |
1991年 | 7篇 |
1990年 | 6篇 |
1989年 | 11篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 6篇 |
1985年 | 3篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 8篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1974年 | 3篇 |
1970年 | 4篇 |
1968年 | 7篇 |
1966年 | 4篇 |
排序方式: 共有780条查询结果,搜索用时 15 毫秒
101.
102.
Chaya Gopalan Gowri M Hegade Tammi N Bay Shaun R Brown Michael R Talcott 《Contemporary topics in laboratory animal science》2005,44(1):7-10
Tribromoethanol typically is used alone as a general anesthetic agent for rodent surgeries. In the present study, the alpha2-adrenergic agonists xylazine and medetomidine were combined with tribromoethanol to examine their use as alternate and safe anesthetic regimes in rats. We also tested the effect of atipamezole, an alpha2-adrenergic antagonist, in reversing the anesthetic effect of the tribromoethanol-medetomidine combination. Male Sprague-Dawley rats were used to evaluate the effects of tribromoethanol (400 mg/kg intraperitoneally [i.p.]) or tribromoethanol (150 mg/kg) and medetomidine (0.5 mg/kg i.p.). Tribromoethanol (400 mg/kg)-treated rats were anesthetized for an average of 10 min, whereas rats that received tribromoethanol (150 mg/kg) and medetomidine (0.5 mg/kg) remained anesthetized for an average of 55 min. Recovery time was approximately 6 min for the tribromoethanol (400 mg/kg) group compared with 21 min for the animals that received tribromoethanol and medetomidine. In a second study, three groups of rats were given tribromoethanol (150 mg/kg) and medetomidine (0.5 mg/kg). Group 1 received atipamezole (an alpha2-antagonist; 2.5 mg/kg i.p.) 10 min after anesthetic induction, and group 2 received the same dosage at 20 min post-induction. Group 3 was allowed to recover without atipamezole treatment. The anesthetic effects in animals from groups 1 and 2 were reversed after administration of atipamezole, whereas group 3 remained anesthetized. This study demonstrates the safe and effective use of tribromoethanol-medetomidine as an anesthetic in the rat. 相似文献
103.
104.
窄蒂肋间穿支型薄皮瓣在手背创面修复中的应用 总被引:3,自引:2,他引:1
介绍一种以肋间动脉皮肤穿支为营养血管的、主要用于修复手背皮肤缺损的薄皮瓣。手术方法是以第4~9肋间血管外侧皮穿支为蒂,蒂部长和宽均为3~5cm,瓣部长宽均可达15cm,远端2/3修薄。术后第7~10天断蒂。应用此窄蒂皮瓣修复15例16只手背创面,皮瓣全部成活。随访6个月~2年,手功能恢复良好。由于手术不需分离肋间主干血管,其操作远较以往报道的岛状或游离肋间血管皮瓣简便和安全,为修复手背创面的理想皮瓣 相似文献
105.
Musculoskeletal modelling in determining the effect of botulinum toxin on the hamstrings of patients with crouch gait 总被引:2,自引:0,他引:2
NS Thompson FRCS RJ Baker PhD AP Cosgrove MD FRCS IS Corry MD FRCS HK Graham MD FRCS FRACS 《Developmental medicine and child neurology》1998,40(9):622-625
This study aimed to determine the effect of hamstring botulinum toxin A (Btx-A) injection in 10 children with crouch gait in terms of changes in muscle length and lower-limb kinematics. Before Btx-A injection limb kinematics were recorded. Maximum hamstring lengths and excursions were calculated by computer modelling of the lower limb. Data were compared with the averaged hamstring lengths of 10 control children. Hamstrings were denned as short if their length was shorter than the average maximum length minus one standard deviation. Gait analysis was repeated 2 weeks after isolated hamstring Btx-A injection. Pre- and postinjection kinematic data and muscle lengths were then compared. Four of 18 injected limbs in three subjects had short medial hamstring before injection, none of the subjects had short lateral hamstrings. Muscle excursion was significantly reduced in the short and adequate maximum muscle length groups. A significant increase in the semimembranosus and semitendinosus length in all of the injected limbs was noted. Only in the short muscle group was a significant increase in muscle excursion observed. Knee extension improved by 13° in the adequate muscle length group and by 15.6° in the short muscle length group. Pelvic tilt and hip flexion increased in both groups non-significantly. Average walking speed postinjection increased from 0.60 ms-1 to 0.71 ms-1 . Short hamstrings are over-diagnosed in crouch gait. Hamstring Btx-A injection in patients with crouch gait produces significant, repeatable muscle lengthening and improved ambulatory function. 相似文献
106.
The authors describe a magnetic resonance imaging method for examination of the glenoid labrum of the shoulder joint that utilizes a radial fast-imaging sequence. Seven shoulders were examined: a total of five in three healthy asymptomatic volunteers, one in a symptomatic patient not suspected of having a lesion of the glenoid labrum, and one in a patient with recurrent shoulder dislocation and surgical proof of an extensive tear of the labrum. The preliminary results suggest that this technique may advantageously demonstrate pathologic changes in the glenoid labrum and may contribute to the evaluation of the unstable and painful shoulder. 相似文献
107.
Sijens PE; Wijrdeman HK; Moerland MA; Bakker CJ; Vermeulen JW; Luyten PR 《Radiology》1988,169(3):615-620
To assess the potential of in vivo magnetic resonance (MR) spectroscopy for breast cancer, hydrogen-1 and phosphorus-31 MR spectra of five malignant human breast tumors were compared with those of unaffected breast tissue. The water-to-fat ratio was high in the tumors (average, 2.2) but low in the unaffected tissue (average, 0.3). The P-31 spectrum of normal breast tissue showed low levels of phosphomonoesters (PMEs), inorganic phosphate, phosphodiesters (PDEs), and ATP. In addition, an intense phosphocreatine (PCr) signal was observed in breast tissue of young women: The relative intensities of the PCr and ATP signals had a mean value of 1.9. The tumor spectrum showed elevated levels of PMEs, Pi, and PDEs, while no PCr was seen (PCr/ATP less than 0.2). In two breast cancers treated with radiation therapy, resulting in a decrease of tumor volume of more than 50%, a similar change in the tumor P-31 spectrum was observed: An intense PCr signal developed (PCr/ATP = 1.1). Control experiments indicated that the appearance of PCr after radiation therapy was the result of a radiation-induced metabolic change in the tumor itself. 相似文献
108.
Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin) 总被引:13,自引:6,他引:7
Saelman EU; Nieuwenhuis HK; Hese KM; de Groot PG; Heijnen HF; Sage EH; Williams S; McKeown L; Gralnick HR; Sixma JJ 《Blood》1994,83(5):1244-1250
Platelet adhesion to fibrillar collagens (types I, II, III, and V) and nonfibrillar collagens (types IV, VI, VII, and VIII) was investigated in the presence of physiologic concentrations of divalent cations under conditions of stasis and flow. Under static conditions, platelet adhesion was observed to collagen types I through VII but not to type VIII. Under flow conditions, platelet adhesion to collagen types I, II, III, and IV was almost independent of shear rates above 300/s. Collagen type V was nonadhesive. Platelet adhesion to collagen type VI was shear rate-dependent and optimal at a rate of 300/s. Collagen types VII and VIII showed minor reactivity and supported platelet adhesion only between shear rates 100 to 1,000/s. Monoclonal antibody (MoAb) 176D7, directed against platelet membrane glycoprotein Ia (GPIa; very late antigen [VLA]-alpha 2 subunit), completely inhibited platelet adhesion to all collagens tested, under conditions of both stasis and flow. Platelet adhesion to collagen type III at shear rate 1,600/s was only inhibited for 85%. The concentration of antibody required for complete inhibition of platelet adhesion was dependent on the shear rate and the reactivity of the collagen. An MoAb directed against GPIIa (VLA-beta subunit) partially inhibited platelet adhesion to collagen. These results show that GPIa-IIa is a major and universal platelet receptor for eight unique types of collagen. 相似文献
109.
Zakaria ZA Gopalan HK Zainal H Mohd Pojan NH Morsid NA Aris A Sulaiman MR 《Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan》2006,126(11):1171-1178
AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40 degrees C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (s.c.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited significant (p<0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (p<0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims. 相似文献
110.
Bhattacharya K Ramakrishnan R Gopalan TR Barua P Vijayaraghavan J 《Journal of the Indian Medical Association》2006,104(6):336-337
Persistent Muellerian duct syndrome is a very rare anomaly. A woman of 46-year-old was admitted with the history of lower abdominal pain, bleeding per vaginum and irregular menstrual cycles for last 6 months. An irregular non-tender mass of 16 x 10cm in size was palpable in suprapubic region. Per vaginal examination revealed two cervices and an incomplete vaginal septum. Ultrasound abdomen showed one uterus with endometrial cavity clearly delineated with a fibroid and an ovarian cyst in the left lumbar region. On laparotomy, 2 uterii along with a fibroid from the anterior wall of left uterus and a left ovarian cyst was seen. Patient had undergone total abdominal hysterectomy and adnexa removal. The specimen showed florid adenomyosis with leiomyoma of fibroid. 相似文献