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971.
Macrino S Slater H Aballay A Goldfarb IW Caushaj PF 《Burns : journal of the International Society for Burn Injuries》2008,34(4):509-511
AIM: To review trends in incidence and treatment of thermal injuries among the elderly. METHOD: A 3-year retrospective review of medical records of people aged 65 years and older admitted to our burn centre over July 2003-June 2006. RESULTS: Elderly people with burns continued to have significant comorbidities. They were often burned because they were inappropriately trying to live alone. Thus discharge was often complicated. CONCLUSIONS: At our burn centre, survival among elderly people with burns has increased, probably as a result of more sophisticated medical, surgical and nursing care, as well as more extensive rehabilitation. 相似文献
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Cystinuria is an inherited disorder characterized by the impaired reabsorption of cystine in the proximal tubule of the nephron and the gastrointestinal epithelium. The only clinically significant manifestation is recurrent nephrolithiasis secondary to the poor solubility of cystine in urine. Although cystinuria is a relatively common disorder, it accounts for no more than 1% of all urinary tract stones. Thus far, mutations in 2 genes, SLC3A1 and SLC7A9, have been identified as being responsible for most cases of cystinuria by encoding defective subunits of the cystine transporter. With the discovery of mutated genes, the classification of patients with cystinuria has been changed from one based on phenotypes (I, II, III) to one based on the affected genes (I and non-type I; or A and B). Most often this classification can be used without gene sequencing by determining whether the affected individual's parents have abnormal urinary cystine excretion. Clinically, insoluble cystine precipitates into hexagonal crystals that can coalesce into larger, recurrent calculi. Prevention of stone formation is the primary goal of management and includes hydration, dietary restriction of salt and animal protein, urinary alkalinization, and cystine-binding thiol drugs. 相似文献
974.
O'Hara JF Bramstedt K Flechner S Goldfarb D 《Progress in transplantation (Aliso Viejo, Calif.)》2007,17(3):180-182
Evaulating patients for living kidney donor transplantation involving a recipient with significant medical issues can create an ethical debate about whether to proceed with surgery. Donors must be informed of the surgical risk to proceed with donating a kidney and their decision must be a voluntary one. A detailed informed consent should be obtained from high-risk living kidney donor transplant recipients as well as donors and family members after the high perioperative risk potential has been explained to them. In addition, family members need to be informed of and acknowledge that a living kidney donor transplant recipient with pretransplant extrarenal morbidity has a higher risk of a serious adverse outcome event such as graft failure or recipient death. We review 2 cases involving living kidney donor transplant recipients with significant comorbidity and discuss ethical considerations, donor risk, and the need for an extended informed consent. 相似文献
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Reduced serum insulin-like growth factor-1 (IGF-1) and hypogonadotrophic hypogonadism are common features of adult β-thalassemia,
and warrant evaluation of the growth hormone (GH)-IGF-1 axis. The aim of this study was to determine GH reserve in β-thalassemia
patients (9 females, 7 males, 15 major, 1 intermedia), age 29.3 ± 6.9 years, BMI 21.3 ± 1.9 kg/m2, and in 20 age, sex and BMI-matched healthy controls, using the GH-releasing hormone (GHRH)–arginine test. The associations
between peak GH response and hormonal and biochemical indices were evaluated. Using BMI-related cut-off limits for peak GH
response in the GHRH–arginine test, 4/16 β-thalassemia patients had peak GH lower than 11.5 μg/l, the cut-off limit suggested
for lean subjects, and were diagnosed as GH deficient (GHD). Using 9 μg/l as the cut-off limit 2/16 patients were GHD. Reduced
serum IGF-1 and IGFBP-3 were present in 69% and 19% of the patients, respectively. Peak GH did not correlate with serum IGF-1,
TSH, and fT4 levels or gonadal status. Neither peak GH nor IGF-1 correlated with serum ferritin. Our findings suggest that GHD is present
in up to a quarter of adult β-thalassemia patients. The clinical benefits of GH therapy need to be determined. GHD alone does
not account for the high prevalence of reduced IGF-1 in adult β-thalassemia. 相似文献
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