罗氟司特治疗有症状的慢性阻塞性肺疾病观察

背景及目的：激素与放疗联合治疗高风险的前列腺癌患者可延长存活期。但患者若同时有其他疾病,是否会影响联合治疗的效果还不清楚。本研究在同时患有冠心病所致的充血性心力衰竭（CHF）或心肌梗死（MI）、或有冠心病危险因素,或无其他共患疾病的前列腺癌患者中,评价辅助性激素治疗是否可影响患者的全因死亡率。     

Familial short stature due to a 5q22.1-q23.2 duplication refines the 5q duplication spectrum

We identified a maternally inherited 14.2Mb duplication 5q22.1-q23.2 in two female siblings and their mother by molecular karyotyping. Both siblings were small for gestational age and presented with pronounced postnatal growth retardation, mild motor delay, congenital heart disease in one of the siblings, and distinct facial dysmorphism. As this duplication is one of the smallest reported 5q duplications, short stature and facial dysmorphism can be attributed to duplications of 5q22, whereas severe mental retardation is not part of the phenotypic spectrum of the 5q22.1-q23.2 region. Congenital heart defects, as observed in other 5q duplications, have a variable penetrance. We compared the facial features of patients with 5q duplications and found some consistent features such as high arched eyebrows, bulbous nasal tip and small lips with thin vermilion border.