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991.
Andrea Imperatori Elisa Nardecchia Maria Cattoni Shehab Mohamed Davide Di Natale Ilaria Righi Paolo Mendogni Cristina Diotti Nicola Rotolo Lorenzo Dominioni Lorenzo Rosso 《Journal of thoracic disease》2021,13(4):2524
Early detection of lung cancer is the key to improving treatment and prognosis of this disease, and the advent of advances in computed tomography (CT) imaging and national screening programs have improved the detection rate of very small pulmonary lesions. As such, the management of this sub-centimetric and often sub-solid lesions has become quite challenging for clinicians, especially for choosing the most suitable diagnostic method. In clinical practice, to fulfill this diagnostic yield, transthoracic needle biopsy (TTNB) is often the first choice especially for peripheral nodules. For lesions for which TTNB could present technical difficulties or failed, other diagnostic strategies are needed. In this case, video-assisted thoracic surgery (VATS) is the gold standard to reach the diagnosis of lung nodules suspect of being malignant. Nonetheless it’s often not easy the identification of such lesions during VATS because of their little dimensions, non-firm consistency, deep localization. In literature various marking techniques have been described, in order to improve intraoperative nodules detection and to reduce conversion rate to thoracotomy: CT-guided hookwire positioning, methylene blue staining, intra-operative ultrasound and electromagnetic navigation bronchoscopy are the most used. The scientific evidence on this matter is weak because there are no randomized clinical trials but only case series on single techniques with no comparison on efficacy, so there are no guidelines to refer. From this standing, in this article we conducted a narrative review of the existing literature on the subject, with the aim of outlining a framework as complete as possible. We analyzed strengths and weaknesses of the main techniques reported, so as to allow the clinician to orient himself with greater ease. 相似文献
992.
Matheus Ribeiro Ávila Pedro Henrique Scheidt Figueiredo Vanessa Pereira Lima Whesley Tanor Silva Marcus Vinícius Accetta Vianna Laís Helena Carvalho Fernandes Alda Cristina Alves de Azevedo Márcia Maria Oliveira Lima Alessandra de Carvalho Bastone Maria do Carmo Pereira Nunes Mauro Felippe Felix Mediano Manoel Otávio da Costa Rocha Henrique Silveira Costa 《Tropical medicine & international health : TM & IH》2021,26(8):936-942
993.
Ramon Z. Shaban Cecilia Li Matthew V. N. O'Sullivan John Gerrard Rhonda L. Stuart Joanne Teh Nicole Gilroy Tania C. Sorrell Elizabeth White Shopna Bag Kate Hackett Sharon C. A. Chen Jen Kok Dominic E. Dwyer Jonathan R. Iredell Susan Maddocks Patricia Ferguson Kavita Varshney Ian Carter Ruth Barratt Mark Robertson Sai R. Baskar Caren Friend Roselle S. Robosa Cristina Sotomayor‐Castillo Shizar Nahidi Deborough A. Macbeth Kylie A. D. Alcorn Andre Wattiaux Frederick Moore Jamie McMahon William Naughton Tony M. Korman Mike Catton Rupa Kanapathipillai Finn Romanes Emily Rowe Jennifer Catford Brendan Kennedy Ming Qiao David Shaw 《Internal medicine journal》2021,51(1):42-51
994.
Pledget-assisted hemostasis to fix residual access-site bleedings after double pre-closure technique
995.
Arturo Ottavio Rinaldi Isabella Sanseverino Cristina Purificato Antonio Cortese Rosella Mechelli Silvia Francisci Marco Salvetti Enrico Millefiorini Sandra Gessani Maria Cristina Gauzzi 《Toxins》2015,7(1):129-137
Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free form. The aim of this study was to investigate whether the circulating levels of either of the two vitD plasma carriers and/or their relationship are altered in MS. We measured DBP and albumin plasma levels in 28 MS patients and 24 healthy controls. MS patients were found to have higher DBP levels than healthy subjects. Concomitant interferon beta therapy did not influence DBP concentration, and the difference with the control group was significant in both females and males. No significant correlation between DBP and albumin levels was observed either in healthy controls or in patients. These observations suggest the involvement of DBP in the patho-physiology of MS. 相似文献
996.
997.
Giovanni Maconi Cristina Bosetti Alberta De Monti Ray Kiran Boyapati Edward Shelton Nicole Piazza Anna Maria Carvalhas Gabrielli Marco Vincenzo Lenti Cristina Bezzio Chiara Ricci Salvatore Greco Samanta Romeo Francesco Giangregorio Daniele Gridavilla Fabio Tagliani Alessandro Massari Luca Pastorelli Antonio Di Sabatino Sandro Ardizzone 《Digestive and liver disease》2021,53(3):263-270
BackgroundIt is unclear whether patients with inflammatory bowel disease (IBD) are at increased risk of COVID-19.ObjectivesThis observational study compared the prevalence of COVID-19 symptoms, diagnosis and hospitalization in IBD patients with a control population with non-inflammatory bowel disorders.MethodsThis multicentre study, included 2733 outpatients (1397 IBD patients and 1336 controls), from eight major gastrointestinal centres in Lombardy, Italy. Patients were invited to complete a web-based questionnaire regarding demographic, historical and clinical features over the previous 6 weeks. The prevalence of COVID-19 symptoms, diagnosis and hospitalization for COVID-19 was assessed.Results1810 patients (64%) responded to the questionnaire (941 IBD patients and 869 controls). IBD patients were significantly younger and of male sex than controls. NSAID use and smoking were more frequent in controls. IBD patients were more likely treated with vitamin-D and vaccinated for influenza. Highly probable COVID-19 on the basis of symptoms and signs was less frequent in the IBD group (3.8% vs 6.3%; OR:0.45, 95%CI:0.28–0.75). IBD patients had a lower rate of nasopharyngeal swab-PCR confirmed diagnosis (0.2% vs 1.2%; OR:0.14, 95%CI:0.03–0.67). There was no difference in hospitalization between the groups (0.1% vs 0.6%; OR:0.14, 95%CI:0.02–1.17).ConclusionIBD patients do not have an increased risk of COVID-19 specific symptoms or more severe disease compared with a control group of gastroenterology patients. 相似文献
998.
Riccardo Marmo Marco Soncini Cristina Bucci Angelo Zullo 《Digestive and liver disease》2021,53(1):102-106
Background/AimThe indiscriminate use of high-dose, proton pump inhibitor (PPI) infusion in non-variceal upper gastrointestinal bleeding (UGIB) patients to reduce the rate of peptic ulcers with high-risk stigmata (HRS) has been questioned. We evaluated the prevalence of HRS on peptic ulcer and non-ulcer lesions in patients receiving or not receiving pre-endoscopic PPI therapy.MethodsData of consecutive UGIB patients observed in 50 Italian centres were analysed. The prevalence of both HRS on peptic ulcers and active bleeding on non-ulcer lesions between patients treated or not treated with PPI were compared. Multivariate analysis was performed.ResultsA total of 1,792 (69.8%) out of 2,566 patients received PPI therapy. Prevalence of HRS on ulcers was 51.8% and 53.4% (P = 0.58) in treated and not treated patients, respectively, and the rate of endoscopic therapy did not differ between groups. Prevalence of non-ulcer bleeding lesions was higher in patients treated than in those not treated with PPI (18.7% vs 10.6%; P = 0.023). At multivariate analysis, PPI therapy (OR: 1.16, 95% CI = 0.82–1.64; P = 0.4) was not an independent factor affecting HRS prevalence, which was inversely correlated with timing to endoscopy (OR: 0.85, 95% CI = 0.76–0.95; P = 0.005).ConclusionsOur data failed to detect a significant role of pre-endoscopic PPI therapy in decreasing prevalence of HRS and need for endoscopic treatment in bleeding patients with either peptic ulcer or non-ulcer lesions. 相似文献
999.