全文获取类型
收费全文 | 559篇 |
免费 | 35篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 30篇 |
妇产科学 | 1篇 |
基础医学 | 51篇 |
口腔科学 | 33篇 |
临床医学 | 48篇 |
内科学 | 121篇 |
皮肤病学 | 17篇 |
神经病学 | 9篇 |
特种医学 | 99篇 |
外科学 | 60篇 |
综合类 | 24篇 |
预防医学 | 32篇 |
眼科学 | 4篇 |
药学 | 49篇 |
中国医学 | 1篇 |
肿瘤学 | 20篇 |
出版年
2021年 | 15篇 |
2020年 | 4篇 |
2019年 | 2篇 |
2018年 | 6篇 |
2017年 | 3篇 |
2016年 | 11篇 |
2015年 | 10篇 |
2014年 | 12篇 |
2013年 | 27篇 |
2012年 | 22篇 |
2011年 | 8篇 |
2010年 | 25篇 |
2009年 | 26篇 |
2008年 | 15篇 |
2007年 | 11篇 |
2006年 | 21篇 |
2005年 | 12篇 |
2004年 | 9篇 |
2003年 | 13篇 |
2002年 | 11篇 |
2001年 | 10篇 |
2000年 | 9篇 |
1999年 | 19篇 |
1998年 | 36篇 |
1997年 | 25篇 |
1996年 | 21篇 |
1995年 | 13篇 |
1994年 | 22篇 |
1993年 | 23篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 13篇 |
1988年 | 15篇 |
1987年 | 9篇 |
1986年 | 14篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 9篇 |
1981年 | 12篇 |
1980年 | 12篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 9篇 |
1975年 | 3篇 |
1970年 | 2篇 |
1968年 | 3篇 |
1956年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有601条查询结果,搜索用时 15 毫秒
111.
Cerebral microgyria, thalamic cell size and auditory temporal processing in male and female rats 总被引:4,自引:2,他引:2
Herman AE; Galaburda AM; Fitch RH; Carter AR; Rosen GD 《Cerebral cortex (New York, N.Y. : 1991)》1997,7(5):453-464
Induction of microgyria by freezing injury to the developing somatosensory
cortex of neonatal rats causes a defect in fast auditory processing in
males, but not in females. It was speculated that early damage to the
cortex has sexually dimorphic cascading effects on other brain regions
mediating auditory processing, which can lead to the observed behavioral
deficits. In the current series of experiments, bilateral microgyri were
induced by placement of a freezing probe on the skulls of newborn male and
female rats, and these animals were tested in adulthood for auditory
temporal processing. Control animals received sham surgery. The brains from
these animals were embedded in celloidin, cut in the coronal plane and the
following morphometric measures assessed: microgyric volume, medial
geniculate nucleus (MGN) volume, cell number, and cell size, and, as a
control, dorsal lateral geniculate nucleus (dLGN) volume, cell number and
cell size. There were no sex differences in the cortical pathology of
lesioned animals. However, microgyric males had more small and fewer large
neurons in the MGN than their sham-operated counterparts, whereas there was
no difference between lesioned and sham-operated females. There was no
effect on dLGN cell size distribution in either sex. Microgyric males were
significantly impaired in fast auditory temporal processing when compared
to control males, whereas lesioned females exhibited no behavioral
deficits. These results suggest that early injury to the cerebral cortex
may have different effects on specific thalamic nuclei in males and
females, with corresponding differences in behavioral effects.
相似文献
112.
MUSTAFA B HOSCAN ALIM KOAR ÜMT GÜMÜTA MEHMET GÜNEY 《International journal of urology》2006,13(3):301-302
Spontaneous migration of an intrauterine device into the bladder is very rare. A 29-year-old woman in whom an intrauterine device had been placed 6 years previously, presented complaining of chronic pelvic pain and recurrent irritative urinary tract symptoms. One year after insertion she had became pregnant and given birth without complications. Intravesical migration of the intrauterine device was confirmed by sonography and cystoscopy. The intrauterine device was removed by suprapubic cystostomy. 相似文献
113.
G D''Andrea AR Cananzi R Joseph M Morra F Zamberlan F Ferro Milone S Grunfeld KMA Welch 《Cephalalgia : an international journal of headache》1991,11(4):197-200
Platelet levels of glutamic and aspartic acid and glycine were measured in patients with migraine with aura, migraine without aura, tension headache and cluster headache. High levels of these amino acids were found in patients with migraine with aura compared to normal subjects and other headache groups. During headache, glutamate levels further increased in migraine with aura patients. These findings may have relevance to the neurological symptoms of migraine with aura. 相似文献
114.
Recombinant human granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem/progenitor cells (PBPC) have replaced bone marrow (BM) harvests for autologous transplantation after myeloablative therapy in cancer patients. G-CSF-mobilized PBPC from healthy donors contain one log excess of T lymphocytes representing a potential risk for graft-versus-host disease (GVHD). However, recent pilot clinical studies of G-CSF-mobilized allogeneic PBPC transplantation have shown rapid haematological recovery and no severe acute GVHD except in a very few cases. Therefore, the risk of inducing severe acute GVHD is not as high as was expected during the pioneering period of allogeneic PBPC transplantation.The present study was performed to address the possible reasons for the rapid haematological recovery and the absence of severe acute GVHD observed after allogeneic PBPC transplantation by comparing the contents and subsets of CD3+ and CD34+ G-CSF-mobilized PBPC (n = 31) with those of BM (n = 26) allografts from healthy adult donors. The present results revealed that the phenotypic profiles of CD3+ and CD34+ cells differ between PBPC and BM allografts. The single PBPC leukapheresis product contained 10 times more mononuclear cells, 1.5 times more CD34+ cells, 5.5 times more CD3+ T lymphocytes, 3 times more CD19+ B lymphocytes and 3.8 times more CD14+ monocytes than the single BM harvest. Both CD34+CD33+ myeloid progenitor cells and CD34+HLA-DR- long-term reconstituting haemopoietic stem cells were significantly increased in the CD34+ G-CSF-mobilized PBPC compared with the CD34+ BM cells; median 73.1% and 30.4% vs 60.6% and 5.0%, respectively, P < 0.01.The percentage of CD3+ cells coexpressing CD4 (T helper/inducer) was similar in both PBPC and BM allografts, 47.2% and 45.6%, respectively, whereas the percentage of CD3+ cells coexpressing CD8 (T suppressor/cytotoxic) was significantly decreased in PBPC compared with BM; 37.0% vs 55.9%, p < 0.01. 相似文献
115.
116.
117.
118.
C Hedman AR Andersen PG Andersson NE Gilhus P Kangasniemi J-E Olsson E Strandman K Nestvold J Olesen 《Cephalalgia : an international journal of headache》1988,8(4):279-284
There is little information available concerning whether, and to what extent, migraine-prophylactic agents interfere with the symptoms of migraine attacks. The present study is a placebo-controlled, double-blind study concerning metoprolol in classic migraine. The data refer to the symptoms of single migraine attacks. During metoprolol treatment more attacks were characterized as mild (p = 0.002), and mean global rating (an integrated estimate of headache intensity and of other discomfort) was lower (4.2 versus 5.2, p = 0.003). The mean headache intensity per attack (1.97 versus 2.15) and the mean duration (5.5 versus 6.8 h) were not significantly different. Consumption of analgesics per attack was lower during metoprolol treatment (0.6 versus 1.1; p = 0.02). Attacks with associated symptoms accompanying the headache were fewer during metoprolol treatment (p = 0.014). Total visual and non-visual aura symptoms occurred with similar frequency, but scintillations and paraesthesia were more frequent during metoprolol treatment, whereas speech disturbances were less frequent. In spite of lower consumption of analgesics, the symptoms appeared milder during metoprolol than during placebo. The pattern of changes indicates that metoprolol exerts its action via the sympathetic nervous system; peripheral vasoconstriction is hardly the underlying mechanism of action. 相似文献
119.
Compliance with antibiotic prophylaxis after urinary tract infection was assessed in 32 children, using a parent questionnaire, and a urine test for antibacterial substances. In 31 (97%) cases, parents reported giving the antibiotics every day but only 22 (69%) of urine tests were positive. Failure to understand the reasons for prophylaxis and non-compliance were significantly associated. 相似文献
120.
In this study we investigated whether the diagnosis of sleep apnoea syndrome (SAS), based on night-time polysomnography (NPSG), can be predicted or excluded by a one-hour daytime polysomnography (DPSG). The results of 306 NPSGs were compared with DPSGs, which were performed the day before. Treated patients were excluded. In the 89 patients with SAS (Apnoea index (AI)>/=5) 59 showed apnoeas during the DPSG and 30 did not. In the 217 without SAS 25 showed apnoeas daring DPSG and 192 did not. Sensitivity for detecting SAS was 66%, the specificity was 88%, the positive predictive value (PPV) 70% and the negative predictive value (NPV) 86%. For relevant SAS (AI>/=10) the NPV would be 95%. We conclude that the one-hour DPSG is not sufficient for diagnosing or excluding SAS with certainty. It can be used to make the presence of relevant SAS unlikely. 相似文献