全文获取类型
收费全文 | 4017篇 |
免费 | 239篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 142篇 |
妇产科学 | 232篇 |
基础医学 | 443篇 |
口腔科学 | 77篇 |
临床医学 | 284篇 |
内科学 | 918篇 |
皮肤病学 | 76篇 |
神经病学 | 156篇 |
特种医学 | 118篇 |
外科学 | 532篇 |
综合类 | 118篇 |
一般理论 | 4篇 |
预防医学 | 146篇 |
眼科学 | 375篇 |
药学 | 347篇 |
中国医学 | 14篇 |
肿瘤学 | 252篇 |
出版年
2024年 | 3篇 |
2023年 | 36篇 |
2022年 | 94篇 |
2021年 | 203篇 |
2020年 | 118篇 |
2019年 | 131篇 |
2018年 | 169篇 |
2017年 | 92篇 |
2016年 | 146篇 |
2015年 | 142篇 |
2014年 | 195篇 |
2013年 | 221篇 |
2012年 | 389篇 |
2011年 | 383篇 |
2010年 | 178篇 |
2009年 | 119篇 |
2008年 | 220篇 |
2007年 | 217篇 |
2006年 | 202篇 |
2005年 | 180篇 |
2004年 | 154篇 |
2003年 | 133篇 |
2002年 | 90篇 |
2001年 | 53篇 |
2000年 | 66篇 |
1999年 | 46篇 |
1998年 | 22篇 |
1997年 | 21篇 |
1996年 | 17篇 |
1995年 | 14篇 |
1994年 | 9篇 |
1993年 | 19篇 |
1992年 | 21篇 |
1991年 | 18篇 |
1990年 | 18篇 |
1989年 | 24篇 |
1988年 | 19篇 |
1987年 | 9篇 |
1986年 | 17篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1981年 | 5篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1970年 | 4篇 |
1969年 | 4篇 |
1968年 | 2篇 |
1967年 | 3篇 |
排序方式: 共有4267条查询结果,搜索用时 78 毫秒
111.
112.
Dinesh Singh Chauhan Yadavalli Guruprasad 《Journal of maxillofacial and oral surgery》2015,14(1):42-46
Goldenhar syndrome, a variant of hemifacial microsomia, is a well-known developmental anomaly of maxillofacial skeleton that is apparent at birth. The first and second branchial arch involvement during early embryonic development results in a wide spectrum of anomalies that may include macrostomia and lateral facial clefts. Though clefts of the orofacial region are among the most common congenital facial defects, the occurrence of lateral facial clefts (Tessier 7 cleft) in conditions such as the Goldenhar syndrome, is very rare (<5%). The lateral facial cleft, which results because of improper development of the perioral muscles of the face, gives an appearance of macrostomia giving rise to potential psychological, aesthetic and feeding problems. This clinical report describes the closure of a Tessier 7 cleft and the use of distraction osteogenesis to treat mandibular asymmetry in an 11-year-old female patient with Goldenhar’s syndrome. 相似文献
113.
Mitochondria organize themselves as dynamic populations within a cell, by undergoing continuous cycles of fission and fusion. The spatio-temporal distribution and abundance of mitochondria determines the cell’s energy budget and is thus intimately linked to the cell’s response to environmental stimuli during aging. The dynamic balance of mitochondrial fission and fusion can be studied in terms of antagonistic subpopulations that regulate the mitochondrial responses in space and time. The dynamic nature of these processes motivates mathematical modelling and the simulation of such complex process. In several neurodegenerative and metabolic diseases the dynamic balance of fission and fusion is disturbed. However, how this dynamics plays a role in the progression of diseases is largely unclear. Fission and fusion help mitochondria to regulate cellular energy (ATP) levels, and minimize accumulation of harmful oxidized material called reactive oxygen species which accelerate mutations in mitochondrial DNA (mtDNA) during aging. We discuss how systems biology approaches can be used to investigate the mechanisms controlling the fission–fusion dynamics under two categories: dissecting the design of its molecular regulatory motifs, and understanding complex mitochondrial responses through their population level interactions. This will help us to understand how different regulatory mechanisms regulate the ATP and mutation (mtDNA) landscape of mitochondria to a variety of environmental stimuli in order to maintain their function during aging. 相似文献
114.
Gaurav Sharma Himanshi Kapoor Madhu Chopra Kaushal Kumar Veena Agrawal 《Parasitology research》2014,113(1):197-209
Malaria and dengue are the two most important vector-borne human diseases caused by mosquito vectors Anopheles stephensi and Aedes aegypti, respectively. Of the various strategies adopted for eliminating these diseases, controlling of vectors through herbs has been reckoned as one of the important measures for preventing their resurgence. Artemisia annua leaf chloroform extract when tried against larvae of A. stephensi and A. aegypti has shown a strong larvicidal activity against both of these vectors, their respective LC50 and LC90 values being 0.84 and 4.91 ppm for A. stephensi and 0.67 and 5.84 ppm for A. aegypti. The crude extract when separated through column chromatography using petroleum ether-ethyl acetate gradient (0–100 %) yielded 76 fractions which were pooled into three different active fractions A, B and C on the basis of same or nearly similar R f values. The aforesaid pooled fractions when assayed against the larvae of A. stephensi too reported a strong larvicidal activity. The respective marker compound purified from the individual fractions A, B and C, were Artemisinin, Arteannuin B and Artemisinic acid, as confirmed and characterized through FT-IR and NMR. This is our first report of strong mortality of A. annua leaf chloroform extract against vectors of two deadly diseases. This technology can be scaled up for commercial exploitation. 相似文献
115.
Anjali Mishra Prateek Kumar Mehrotra Gaurav Agarwal Amit Agarwal Saroj Kanta Mishra 《Indian pediatrics》2014,51(4):299-302
Objectives
To describe the clinical presentation and outcome of surgery in children with pheochromocytoma in a tertiary care hospital in India.Methods
Clinical records of 24 children who were operated between January 1990 and January 2011 were reviewed. The diagnosis of familial disease was established based on clinical examination and follow-up events.Results
Familial, bilateral, extra-adrenal and malignant pheochromocytoma were observed in 20.8%, 20.8%, 12.5% and 4.2% children, respectively. Median follow-up duration was 36 months. Persistent hypertension was noted in 12.5% patients and similar proportion died in follow-up.Conclusions
In the absence of routine genetic screening, good history and long-term follow up are essential to rule out familial pheochromocytoma. 相似文献116.
Lawrence A. Lavery Douglas P. Murdoch Paul J. Kim Javier La Fontaine Gaurav Thakral Kathryn E. Davis 《Journal of diabetes science and technology》2014,8(2):346-349
This study was a prospective cohort study to evaluate negative pressure wound therapy (NPWT) with low pressure and a gauze dressing to treat diabetic foot wounds. Thirty patients with diabetic foot wounds were consented to a prospective study to evaluate wound closure and complications to evaluate NPWT with low pressure (80 mmHg) and a gauze dressing interface (EZCare, Smith and Nephew) for up to 5 weeks. NPWT was changed 3 times a week. Study subjects were evaluated once a week for adverse events and wound measurements. Of study subjects, 43% attained at least a 50% wound area reduction after 4 weeks of therapy. Our results suggest that a high rate of wound closure could be expected with low pressure and a gauze interface. 相似文献
117.
Rupesh Raina Shyam Polaconda Nikhil Nair Ronith Chakraborty Sidharth Sethi Vinod Krishnappa Gaurav Kapur Maroun Mhanna Kirsten Kusumi 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(6):1059-1069
The morbidity and mortality of adult and pediatric chronic kidney disease (CKD) and end‐stage renal disease (ESRD) populations are mainly driven by cardiovascular disease (CVD). Improving CVD outcomes focuses on risk assessment of factors including diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular mass index (LVMI), pulse pressure (PP), and pulse pressure index (PPi), which is calculated as PP/SBP. These markers are also proven predictors of CKD progression; however, their role in children has not been established. This study aims to evaluate the relationship between PP, PPi, ambulatory arterial stiffness index (AASI), and proteinuria with kidney function in pediatric CKD patients; it is a retrospective analysis of 620 patients (1‐16 years) from the NIDDK Chronic Kidney Disease in Children (CKiD) registry. The authors analyzed data for three separate cohorts: an overall CKD as well as immunological versus non‐immunological cause for CKD groups. An inverse relationship was found between SBP, DBP, and PP with iGFR and LVMI in the overall CKD group. Our immunological CKD subgroup showed significantly higher serum creatinine, SBP, DBP, and PP values with significantly lower serum albumin levels compared to the non‐immunological group. There were no significant differences with iohexol‐based glomerular filtration rate (iGFR), LVMI, PPi, or high‐sensitivity C‐reactive protein (hs‐CRP) between the two groups. A subgroup analysis demonstrated that SBP, DBP, and PP all correlated significantly with LVMI in the immunological CKD patients but not the non‐immunological subgroup. Additionally, AASI data in the overall CKD population were significantly correlated with PP, PPi, and DBP. This study is one of the first to correlate noninvasive measurements of vascular compliance including PP, PPi, and AASI with iGFR and LVMI in a pediatric CKD cohort. Improving our understanding of surrogate markers for early CVD is integral to improving the care of pediatric CKD population as these patients have yet to develop the hard end points of ESRD, heart failure, myocardial infarction, or stroke. 相似文献
118.
119.
120.
Majumder S Dey R Bhattacharjee S Rub A Gupta G Bhattacharyya Majumdar S Saha B Majumdar S 《The Journal of infectious diseases》2012,205(10):1607-1616
The initial macrophage-Leishmania donovani interaction results in the formation of membrane platforms, termed lipid rafts, that help in the entry of the parasite. Therefore, it is imperative that the parasite designs a strategy to modulate its uptake and survival within the macrophages. Herein, we report Leishmania-triggered biphasic ceramide generation. In the first phase, L. donovani promastigotes induce activation of acid sphingomyelinase (ASMase), which catalyzes the formation of ceramide from sphingomyelin. Inhibition of ASMase resulted in reduced uptake and infection with the parasite. In the second phase, de novo synthesis generates ceramide that reduces the cellular cholesterol level and displaces the cholesterol from the membrane, leading to enhanced membrane fluidity, disruption of rafts, and impaired antigen-presentation to the T cells. The results reveal a novel role for ceramide in the perspective of L. donovani infection and help formulate an antileishmanial strategy that can possibly be applied to other intracellular infections as well. 相似文献