全文获取类型
收费全文 | 2927篇 |
免费 | 187篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 121篇 |
妇产科学 | 40篇 |
基础医学 | 329篇 |
口腔科学 | 67篇 |
临床医学 | 359篇 |
内科学 | 615篇 |
皮肤病学 | 28篇 |
神经病学 | 173篇 |
特种医学 | 31篇 |
外科学 | 224篇 |
综合类 | 54篇 |
一般理论 | 2篇 |
预防医学 | 397篇 |
眼科学 | 75篇 |
药学 | 371篇 |
中国医学 | 55篇 |
肿瘤学 | 154篇 |
出版年
2024年 | 8篇 |
2023年 | 61篇 |
2022年 | 233篇 |
2021年 | 275篇 |
2020年 | 134篇 |
2019年 | 131篇 |
2018年 | 131篇 |
2017年 | 99篇 |
2016年 | 106篇 |
2015年 | 89篇 |
2014年 | 121篇 |
2013年 | 170篇 |
2012年 | 199篇 |
2011年 | 210篇 |
2010年 | 96篇 |
2009年 | 64篇 |
2008年 | 107篇 |
2007年 | 96篇 |
2006年 | 91篇 |
2005年 | 93篇 |
2004年 | 89篇 |
2003年 | 80篇 |
2002年 | 89篇 |
2001年 | 31篇 |
2000年 | 34篇 |
1999年 | 38篇 |
1998年 | 18篇 |
1997年 | 39篇 |
1996年 | 11篇 |
1995年 | 10篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 11篇 |
1989年 | 4篇 |
1988年 | 13篇 |
1985年 | 5篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1972年 | 4篇 |
1971年 | 4篇 |
1968年 | 3篇 |
1963年 | 4篇 |
排序方式: 共有3124条查询结果,搜索用时 15 毫秒
51.
Rapid and correct diagnosis of acute myocardial infarction (AMI) plays a crucial role in saving patients'' life. Although some biomarkers (such as cardiac troponin and creatine kinase) are available for AMI diagnosis so far, there is still a clinical need for novel biomarkers, which can reliably rule in or rule out AMI immediately on admission. Circulating microRNAs (miRNAs) are a potential choice for novel biomarkers in AMI diagnosis and prognosis with high sensitivity and specificity. Circulating microRNAs are endogenous miRNAs that are detectable in whole blood, serum, or plasma in a highly stable form. Until now, around 20 circulating miRNAs were reported to be closely associated with AMI. In this minireview, we summarized recent available data on the correlation between circulating miRNAs and AMI. Some miRNAs, such as miR-208, miR-499, miR-133, and miR-1, were given special attention, since they may have a potential prospect in diagnosis and prognosis of AMI. 相似文献
52.
Hirotsugu Uemura Dingwei Ye Ravindran Kanesvaran Edmund Chiong Bannakij Lojanapiwat Yeong-Shiau Pu Sudhir Kumar Rawal Azad Hassan Abdul Razack Hao Zeng Byung Ha Chung Noor Ashani Md Yusoff Chikara Ohyama Choung Soo Kim Sunai Leewansangtong Yuh-Shyan Tsai Yanfang Liu Weiping Liu Maximiliano van Kooten Losio Marxengel Asinas-Tan 《BJU international》2020,125(4):541-552
53.
54.
55.
B Nahar MI Hossain JD Hamadani T Ahmed S Grantham-McGregor LA Persson 《BMC public health》2012,12(1):622
ABSTRACT: BACKGROUND: Parenting programmes are effective in enhancing parenting practices and child development. This study evaluated the effects of a intervention with psychosocial stimulation (PS) on the quality of the home environment and mothers' child-rearing practices in a community-based trial with severely malnourished Bangladeshi children. METHOD: Severely underweight children (n = 507), 6-24 months of age, were randomly assigned to five groups: PS; food supplementation (FS); PS + FS; clinic-control (CC); and, hospital-control (CH). PS included fortnightly follow-up visits for six months at community clinics where a play leader demonstrated play activities and gave education on child development and child rearing practices. FS comprised cereal-based supplements (150-300 kcal/day) for three months. All groups received medical care, micronutrient supplements and growth monitoring. Mothers were given the Home Observation for Measurement of the Environment (HOME) inventory and a questionnaire on parenting at baseline and after six months to assess the outcome. RESULTS: 322 children completed the study. After six months of intervention the PS + FS and PS groups benefitted in the total HOME score (depending on the comparison group, effect sizes varied from 0.66 to 0.33 SD) The PS + FS and PS groups also benefitted in two HOME subscales: maternal involvement (effect sizes: 0.8 to 0.55 SD) and play materials, (effect sizes: 0.46 to 0.6 SD), and child-rearing practices scores (effect size: 1.5 to 1.1 SD). The PS + FS group benefitted 4.0 points in total HOME score compared with CH, 4.8 points compared with CC and 4.5 points compared with FS (p < 0.001 for all). The PS group benefitted 2.4 points compared with CH (p = 0.035), 3.3 points compared with CC (p = 0.004), and 2.9 points compared with FS (p = 0.006). Child-rearing practice scores of the PS + FS group improved 7.7, 6.4 and 6.6 points and the PS group improved 8.5, 7.2 and 7.4 points more than CH, CC and FS, respectively (p < 0.001 for all). CONCLUSIONS: Child-rearing practices of mothers of severely malnourished children and the quality of their home environment can be improved through community-based psychosocial stimulation with or without food supplementation. This may be of importance to promote child development. 相似文献
56.
Md. Rezwan Miah Takeo Ohsaka 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》2009,633(1):71-77
Oxygen reduction reaction (ORR) was investigated using polycrystalline gold (Au (poly)) electrode modified with chemisorbed iodine (I(ads)) submonolayer (sub I(ads)) in O2-saturated 0.1 M KOH solution. The sub I(ads) was tailored by potential-dependent partial reductive desorption of I(ads) from its full monolayer. The Au (1 1 1) facet of the Au (poly) electrode was considered to remain bared at the sub I(ads)/Au (poly) electrode. The interesting finding of the present study is that (unlike the bare Au (poly) electrode) the sub I(ads)/Au (poly) electrode exhibited a quasi-reversible two-electron reduction of O2 in alkaline media. The probable origin of the observed quasi-reversible behavior of the ORR is discussed. Experimental investigations were performed using cyclic and steady-state voltammetric, amperometric and coulometric techniques. 相似文献
57.
Malignant pleural mesothelioma caused by environmental exposure to asbestos in the Southeast of Turkey: CT findings in 117 patients 总被引:4,自引:0,他引:4
Senyiğit A Bayram H Babayiğit C Topçu F Nazaroğlu H Bilici A Leblebici IH 《Respiration; international review of thoracic diseases》2000,67(6):615-622
BACKGROUND AND OBJECTIVES: Malignant pleural mesothelioma (MPM) is reported to be common in the southeast of Turkey, as a result of environmental asbestos exposure. The aim of this study was to evaluate the computed tomography (CT) features of MPM in patients with a history of asbestos exposure. METHODS: The CT scans of 117 patients who had a diagnosis of MPM were retrospectively evaluated. Additionally, CT findings of histologic subtypes were compared. RESULTS: The most common CT findings included pleural effusion (n = 104, 89%), pleural thickening (n = 96, 82%), mediastinal pleural involvement (n = 77, 66%) and interlobar fissural involvement (n = 62, 53%). Histologic subtype analysis was performed in 89 patients; of these, epithelial, sarcomatous and mixed types were identified in 46, 23 and 20 patients, respectively. An analysis of CT findings demonstrated that the involvement of mediastinal pleural (91%), interlobar fissure (87%) and lung parenchyma (48%) was significantly more frequent in sarcomatous type, as compared to epithelial (61% and p < 0.01; 35 and 4%, p < 0.0001, respectively) and mixed types (65% and p < 0.05; 10% and p < 0.0001; 10% and p < 0.01, respectively). Furthermore, there was a significant correlation between pericardial involvement and chest wall involvement (r = 0.42, p < 0.05) in sarcomatous type. Similarly, lymphadenopathy and parenchymal involvement (r = 0.23, p < 0.02), pericardial and chest wall involvement (r = 0.25, p < 0.01), chest wall and interlobar fissural involvement (r = 0.25, p < 0.01) were significantly correlated, when CT findings of all histologic subtypes were combined. CONCLUSIONS: These results suggest that although CT findings of MPM vary, they may provide valuable clues to the diagnosis, at least in patients with a history of asbestos exposure. In addition, the presence of extensive lesions may suggest MPM of sarcomatous subtype. 相似文献
58.
Sanmoy Karmakar Sreerupa Biswas Rammohan Bera Samiran Mondal Amit Kundu Md Asif Ali Tuhinadri Sen 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2015,23(2):327
The present study was undertaken to investigate the food–drug interaction of carbamazepine (CBZ). Common fruit juices [grapefruit juice (GFJ), lime juice (LJ)], known to inhibit the enzyme cytochrome P450 3A4 (CYP3A4), and some widely consumed beverages [milk (M), black tea (BT)] were involved in this study in the presence of CBZ, as might happen during clinical therapy. The effects of the beverages on the pharmacokinetics and drug-induced toxicity of CBZ was observed after concomitant administration for a period of 28 days. Accordingly, the influence of altered bioavailability of CBZ on its antiepileptic activity was investigated. A significant shift in the Cmax as well as Tmax of CBZ was observed in the presence of LJ and GFJ. This increase in bioavailability significantly enhanced hepatotoxicity and delayed the onset of tremor and piloerection against pentylene tetrazole (PTZ)-induced seizure in experimental animals. However, increased toxicity of CBZ was found to be absent with BT. Thus, from our observation, LJ or GFJ in the presence of CBZ significantly increased the bioavailability of CBZ, which might lead to increased toxicity and antiepileptic activity of the drug. 相似文献
59.
60.
Metabolic Brain Disease - Alzheimer’s disease (AD) is the most common dementia with currently no known cures or disease modifying treatments (DMTs), despite much time and effort from the... 相似文献