Urinary Excretion of I131-Diodrast Injected Intraventricularly in Communicating Hydrocephalus and Aqueduct Stenosis

Nine cases of expansive infantile hydro-cephalus were investigated by injecting Small amounts of I¹³¹-Diodrast intra-ventricularly. Urinary excretion of the tracer was determined during the first 4-5 hours after injection. The cumulative excretion of Diodrast from the C.S.F. differs in cases with communicating hydrocephalus from those with stenosis of the aqueduct. The investigation is rapid and easily performed and has not produced any side effects.     

Acid hydrolases in blister fluid

Acid phosphatase has been characterized and quantified in human suction blister fluid, interstitial fluid and serum. The acid phosphatases of suction blister fluid and serum showed differences in their pH activity curves, Michaelis-Menton constants, heat stabilities and sensitivities to inhibition by tartrate and fluoride. The behaviour of the interstitial fluid enzyme was intermediate between these two. The levels of activity in blister fluid and serum were very similar, both being more than twice that of interstitial fluid. These results suggest that the acid phosphatase activity in suction blister fluid is derived largely from the overlying epidermis rather than from serum.     

A 4-month study on the effect of chlorhexidine mouth washes on 50 soldiers

abstract – Aqueous solutions of chlorhexidine salts have been used as mouth washes to supplement routine oral hygiene in a group of young adults for a period of 4 months. In the first part of the study (2 months) the effect of plaque formation and gingival condition in the presence of calculus and rough surfaces was studied. Under such circumstances the chlorhexidine mouth washes reduced the amount of plaque on an average of 66%, whereas the gingival inflammation was reduced by 24% in the same period. In the next 2 months the effect of chlorhexidine was studied on scaled and polished teeth. The plaque reduction was now 84% and the Gingival Index values were reduced by 43% after subgingival scaling. No effect on gingival inflammation adjacent to pockets exceeding 3 mm was observed.     

Effect of nutritional hyperparathyroidism on experimental periodontitis in the dog

abstract – The purpose of the present investigation was to induce osteopenia of the alveolar process by feeding dogs a calcium-deficient, phosphorus-rich diet, and to determine whether dogs suffering from nutritional secondary hyperparathyroidism (NSH) developed: (1) increased tooth mobility, (2) gingivitis and (3) periodontitis with marginal alveolar bone resorption in plaque-free areas and in areas where plaque and calculus were allowed to accumulate. The experiments were performed on six, 12-month-old Beagle dogs. During an experimental period of 18 months, four dogs (test group) were fed a low calcium, high phosphorus diet of a soft consistency. The controls were fed an adequate but soft diet. The teeth of the right jaws were regularly subjected to thorough cleaning. NSH and osteopenia of the alveolar bone were induced in the test dogs. Osteopenia, however, did not result in an increased tooth mobility or gingivitis in the absence of plaque. In areas where dental deposits were allowed to accumulate, pathologic pockets gradually developed in both test and control animals, but the degree of attachment loss was the same in both groups.