全文获取类型
收费全文 | 316篇 |
免费 | 25篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 5篇 |
妇产科学 | 5篇 |
基础医学 | 38篇 |
口腔科学 | 5篇 |
临床医学 | 92篇 |
内科学 | 21篇 |
皮肤病学 | 9篇 |
神经病学 | 2篇 |
特种医学 | 53篇 |
外科学 | 14篇 |
综合类 | 10篇 |
预防医学 | 22篇 |
眼科学 | 1篇 |
药学 | 51篇 |
中国医学 | 4篇 |
肿瘤学 | 14篇 |
出版年
2019年 | 3篇 |
2017年 | 2篇 |
2015年 | 4篇 |
2014年 | 3篇 |
2013年 | 5篇 |
2012年 | 14篇 |
2011年 | 10篇 |
2010年 | 14篇 |
2009年 | 8篇 |
2008年 | 15篇 |
2007年 | 14篇 |
2006年 | 20篇 |
2005年 | 19篇 |
2004年 | 16篇 |
2003年 | 16篇 |
2002年 | 7篇 |
2001年 | 10篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 11篇 |
1997年 | 12篇 |
1996年 | 17篇 |
1995年 | 16篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 7篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 8篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1932年 | 1篇 |
1931年 | 2篇 |
1929年 | 1篇 |
1928年 | 5篇 |
1926年 | 1篇 |
1898年 | 1篇 |
1891年 | 1篇 |
1890年 | 1篇 |
1887年 | 1篇 |
排序方式: 共有348条查询结果,搜索用时 15 毫秒
101.
肺靶向顺铂白蛋白微球的研究 总被引:7,自引:0,他引:7
按正交设计筛选了用乳化一化学交联法制备肺靶向顺铂白蛋白微球的最佳制备工艺,并对微球的质量、稳定性、体内分布、动力学特性和安全性进行了系统研究。结果:微球表面圆整,平均粒径为13.13±3.55μm,药物包裹率为21.62%,释药特性符合双相动力学方程;微球在三种条件下贮放了3个月质量稳定;静脉注入小鼠体内,15min分布达高峰,97.52%浓集于肺部,2~3d内基本清除,在肺器官中的动力学特性可用二室开放性模型描述;肺器官病理切片观察,微球对肺组织无病理性损伤。 相似文献
102.
Simulated pulmonary nodules: detection with dual-energy digital versus conventional radiography 总被引:9,自引:0,他引:9
Niklason LT; Hickey NM; Chakraborty DP; Sabbagh EA; Yester MV; Fraser RG; Barnes GT 《Radiology》1986,160(3):589-593
Performance of a prototype dual-energy digital chest radiography unit in detecting calcified and noncalcified simulated pulmonary nodules was compared with that of a highly optimized, conventional system. Nodules ranging in size (0.5, 1.0, and 1.6 cm), in number (five to 11), and in calcium content (0-25 mg) were superimposed over the lungs of a frozen, unembalmed, human chest phantom. For each technique, six observers examined 50 posteroanterior projections with different randomized nodule locations. Detection consisted of locating and assigning a level of confidence to each perceived nodular opacity. The resulting plots of the true-positive fraction versus the mean number of false-positive calls per projection indicate that for both calcified and noncalcified nodules, the digital unit performed significantly better (P less than .01). 相似文献
103.
104.
Brien S Lewith G Walker A Hicks SM Middleton D 《Evidence-based complementary and alternative medicine : eCAM》2004,1(3):251-257
Bromelain, an extract from the pineapple plant, has been demonstratedto show anti-inflammatory and analgesic properties and may providea safer alternative or adjunctive treatment for osteoarthritis.All previous trials, which have been uncontrolled or comparativestudies, indicate its potential use for the treatment of osteoarthritis.This paper reviews the mechanism of its putative therapeuticactions, those clinical trials that have assessed its use inosteoarthritis to date, as well as considering the safety implicationsof this supplement for osteoarthritis and reviewing the evidenceto date regarding the dosage for treating this condition. Thedata available at present indicate the need for trials to establishthe efficacy and optimum dosage for bromelain and the need foradequate prospective adverse event monitoring in such chronicconditions as osteoarthritis. 相似文献
105.
Results from our laboratory have revealed that seminal plasma concentration of acid phosphatase, maltase, prolactin, citric acid, zinc and magnesium which are the secretory products of the prostate gland, decreased significantly in vasectomized men compared to those in controls namely normal fertile men. Further, it was observed that the decrease in prostatic function was not related to the time since vasectomy. Considering these two facts together, we propose that vasectomy may lead to decrease in the incidence of prostatic tumors — a disease that claims nearly 22,000 lives each year in the United States alone. 相似文献
106.
This study analyses the attitudes of Western trained doctors to traditional Chinese medicine (TCM) in Shenyang, Northern China. Research methodology involved a series of structured interviews as well as developing a questionnaire. Two hundred and fifty questionnaires were distributed in four centres, 177 were returned. Ninety-eight percent of respondents had some theoretical and practical TCM training; the older doctors having significantly more than their recently qualified colleagues. There was clear consensus that TCM (mainly herbal medicine) was useful and safe in treating patients with chronic or intractable illness. Doctors were influenced in their choice of treatment by their training, clinical experience and the available published research. TCM was not practiced in isolation, but in conjunction with Western medicine; 76% treating their patients with TCM, 90% treating their friends or family and 82% referring patients to TCM specialists. 相似文献
107.
Background
Searches for differentially expressed genes in tumours have made extensive use of array technology. Most samples have been obtained from tumour biopsies or from established tumour-derived cell lines. Here we compare cultures of non-immortalized breast cancer cells, normal non-immortalized breast cells and immortalized normal and breast cancer cells to identify which elements of a defined set of well-known cancer-related genes are differentially expressed. 相似文献108.
109.
Complementary medicine and the general practitioner 总被引:10,自引:0,他引:10
The attitudes to complementary medicine of a random sample of general practitioners in Avon were assessed. A questionnaire was sent to 200 general practitioners, of whom 145 responded. The treatments studied were acupuncture, homoeopathy, herbal medicine, spinal manipulation, faith healing, and hypnosis. Of the 145 general practitioners, 55 (38%) had received some training in complementary medicine and 22 (15%) wished to arrange training. Overall, general practitioners knew little about the techniques of complementary medicine. Despite this 86 doctors (59%) thought that the complementary techniques being assessed were useful to their patients: 110 (76%) had referred patients for this type of treatment over the past year to medically qualified colleagues and 104 (72%) had referred patients to non-medically qualified practitioners. Most (93%) of those who responded believed that complementary practitioners needed statutory regulation; only 3% thought that they should be banned. The method of regulation most favoured was through a central and independent national body. General practitioners' views about complementary techniques were most influenced (in a positive manner) by observed benefits to their patients (41%) and personal or family experience of benefit (38%). The results of the study show a surprisingly high interest in complementary medicine among general practitioners in the Avon area. 相似文献
110.
考察了不同配方硫酸庆大霉素毫微球的体外释药动力学特征。分别用3种数学模型对释药数据进行拟合,结果表明,双指数函数模型能较好地描述硫酸庆大霉素从毫微球中的释药规律,据此计算了释药动力学参数。试验表明,毫微球的粒度、稳定剂的种类、制备工艺和载药量等对释药过程均有影响。 相似文献