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Nurefsan Boyaci Dilek Sen Dokumaci Ekrem Karakas Funda Yalcin Ayse Gul Oney Kurnaz 《Diagnostic and interventional radiology (Ankara, Turkey)》2015,21(1):42-46
PURPOSE
We aimed to determine the prevalence of paratracheal air cysts (PTACs) and the relationship of PTACs with emphysema and bronchiectasis through retrospective analysis of multidetector computed tomography (MDCT) findings.METHODS
MDCT findings of 1027 consecutive patients who underwent routine thorax examination between January 2012 and January 2013 were evaluated retrospectively for the presence of PTACs. Localization of the PTACs, as well as their size, shape, and relationship with the trachea were examined. Presence of emphysema and bronchiectasis was recorded, and bronchiectasis severity index was calculated when present. We randomly selected 80 patients who had no visible PTACs as the control group. The findings of patients with and without PTACs were compared.RESULTS
PTACs were determined in 82 of 1027 patients (8%), in 8.8% of females and 7.3% of males. The presence of PTACs was determined to be independent of gender (P = 0.361). Eighty-one PTACs (98.8%) were located in the right side of the trachea and 56.1% had a tracheal connection. The presence of PTACs significantly correlated with the presence and severity of bronchiectasis (P = 0.001 and P = 0.005 respectively). There was no significant relationship between the presence of PTACs and the presence of emphysema on CT images (P = 0.125).CONCLUSION
The prevalence of PTACs was determined as 8% in this study. There was significant association between PTACs and bronchiectasis.Paratracheal air cysts (PTACs) are small collections of air adjacent to the trachea at the level of the thoracic inlet (1). Pathological diagnosis of PTACs in surgically confirmed cases includes tracheal diverticulum, lymphoepithelial cyst, and bronchogenic cyst (1–3). These cysts are covered with ciliary columnar epithelium and connected with the trachea (4). The majority of PTACs are reported as tracheal diverticula in the literature, due to their connection with the trachea (2). The thoracic inlet between the cartilage and muscle layers in right posterolateral wall of the trachea is the most common location for PTACs. A relationship may be seen between an isolated PTAC and the trachea l lumen (5). These lesions may cause recurrent infections by acting as a reservoir for secretions.Occasionally, PTACs can be confused with other causes of extraluminal air collections as laryngocele, pharyngocele, Zenker’s diverticulum, apical hernia of the lung, mediastinal air, apical paraseptal blebs, or bullae. To distinguish PTACs from other pathologies, its typical location in the right posterior paratracheal region at the thoracic inlet can be helpful: PTACs locate away from the lung pleura, communicate with the trachea and have rounded margins that can be differentiated from emphysematous changes (6).PTACs are usually discovered incidentally on thorax computed tomography (CT). They may be associated with a chronic cough or chronic obstructive pulmonary diseases (COPD). The reported prevalence of PTACs ranges from 0.75% to 8.1% (4, 6–8). There have been a limited number of studies reporting the incidence of PTACs related to COPD or emphysema as detected by CT, and the reported results are variable (4, 6, 8–11). The relationship between PTACs and pulmonary emphysema or bronchiectasis is still unclear. To our knowledge, no published study has evaluated the relationship between PTACs and bronchiectasis, using a bronchiectasis severity index and objective measures to determine the extent of bronchiectasis on CT images.The purpose of our study was to evaluate the prevalence and characteristics of PTACs, as well as their relationship with bronchiectasis and emphysema, on thorax CT scans. 相似文献23.
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Fatih Ceran Salih Onur Basat Karaca Basaran Funda Akoz Saydam 《Journal of hand and microsurgery》2015,7(1):228-229
Trigger finger (TF) is a condition that affects quality of life and one of the most common causes of hand pain and disability. TF is characterized by catching, snapping or locking of the involved finger flexor tendon, associated with pain. TF in the children occurs rarely than in adults and partial tendon laceration is an uncommon cause of TF in the children. Thus, our aim in this study to define TF due to partial flexor tendon laceration in a child.
Electronic supplementary material
The online version of this article (doi:10.1007/s12593-015-0180-8) contains supplementary material, which is available to authorized users. 相似文献26.
To determine the stage of the disease, performance status of the patients on admission and treatment modalities, records of 226 patients with lung cancer diagnosed between January 1992 and December 1999 were evaluated retrospectively. The mean age of the patients were 61.3 +/- 10.3 years (mean +/- standard deviation) and 217 (96%) were men and 9 (4%) were women. Of the 192 cases with non-small cell lung cancer 22.9% were stage 4, 40.6% were stage 3b, 22.4% were stage 3a, 4.2% were stage 2, 9.9% were stage 1. Of the 34 (15.1%) patients with small cell lung cancer, 26.5% were extensive and 73.5% were in limited stages. The performance status according to European Cooperative Oncology Group (ECOG) was between 0-2 in 88.4% and 3-4 in 11.6% of the cases. A positive correlation between the performance status and the stage of the disease was observed (p= 0.0331). It was detected that the performance status of the patients who underwent surgery was better than the patients who treated with radiotherapy (p= 0.0008). Radiotherapy (RT), chemotherapy (CT), surgery, combined therapy (RT + CT), adjuvant RT and palliative therapy were performed in 27%, 20.4%, 11.5%, 1.3%, 1.8% and 14.6% of the cases respectively. No information about treatment protocol was able to obtained in 23.4% of the patients, probably due to referrals, early deaths etc. In conclusion, more than half of our cases with lung cancer were diagnosed in advanced stages as a possible result of late admission to physician and surgery were performed in only a small part of the cases. It was detected that performance status of the patients operated was better than the patients treated with radiotherapy. On the other hand, combination therapy was applied in few cases. 相似文献
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Genotype–Phenotype Correlations by Ethnicity and Mutation Location in BRCA Mutation Carriers 下载免费PDF全文
Soley Bayraktar MD MBA Michelle Jackson MS Angelica M. Gutierrez‐Barrera MS Diane Liu MS Funda Meric‐Bernstam MD Amanda Brandt MS Ashley Woodson MS Jennifer Litton MD Karen H. Lu MD Vicente Valero MD Banu K. Arun MD 《The breast journal》2015,21(3):260-267
The genotype–phenotype correlations of the specific BRCA1 and BRCA2 mutations in multi‐ethnic populations in USA have not yet been fully investigated. This study was designed to evaluate the effects of ethnicity at specific mutation locations and breast/ovarian cancer phenotypes. Our cohort included 445 women with different ethnic backgrounds who underwent BRCA genetic testing between 1997 and 2010. Known clinical and pathologic characteristics were compared with Chi‐Square Analysis or Fisher's Exact test as appropriate. The three most common mutation locations in BRCA1 (exons 2, 11, and 20) and BRCA2 (exons 10, 11, and 25) genes were chosen. Prevalence of BRCA1 exon 2 mutations were significantly higher in Ashkenazi Jewish (AJ) women compared to Caucasians (41% versus 15%; p = 0.001). Similarly, AJ women with breast cancer were more likely to have BRCA1 exon 2 mutation (47% positivity in AJ women versus 0–12.5% positivity in other ethnicities; p = 0.004). Women carrying the exon 20 BRCA1 mutation had the highest probability of having combined breast and ovarian cancers compared to women carrying other exon mutations (p = 0.05). The median age at initial cancer diagnosis, phenotypic features of breast cancer tumors, and overall survival did not vary significantly by ethnicity or mutation location. Our data suggest that ethnicity does not affect age of onset, overall survival or confer different risks of breast and ovarian cancer development in BRCA carriers. These results also suggest that women carrying the exon 20 BRCA1 mutation may warrant mutation‐specific counseling and be more aggressively managed for risk reduction. 相似文献
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