全文获取类型
收费全文 | 4480篇 |
免费 | 244篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 61篇 |
妇产科学 | 24篇 |
基础医学 | 711篇 |
口腔科学 | 82篇 |
临床医学 | 287篇 |
内科学 | 1288篇 |
皮肤病学 | 18篇 |
神经病学 | 304篇 |
特种医学 | 109篇 |
外科学 | 652篇 |
综合类 | 25篇 |
预防医学 | 125篇 |
眼科学 | 238篇 |
药学 | 264篇 |
中国医学 | 9篇 |
肿瘤学 | 522篇 |
出版年
2023年 | 34篇 |
2022年 | 62篇 |
2021年 | 106篇 |
2020年 | 55篇 |
2019年 | 65篇 |
2018年 | 73篇 |
2017年 | 77篇 |
2016年 | 83篇 |
2015年 | 93篇 |
2014年 | 138篇 |
2013年 | 144篇 |
2012年 | 255篇 |
2011年 | 260篇 |
2010年 | 126篇 |
2009年 | 133篇 |
2008年 | 236篇 |
2007年 | 266篇 |
2006年 | 249篇 |
2005年 | 245篇 |
2004年 | 257篇 |
2003年 | 249篇 |
2002年 | 221篇 |
2001年 | 113篇 |
2000年 | 122篇 |
1999年 | 112篇 |
1998年 | 70篇 |
1997年 | 59篇 |
1996年 | 36篇 |
1995年 | 42篇 |
1994年 | 44篇 |
1993年 | 22篇 |
1992年 | 77篇 |
1991年 | 61篇 |
1990年 | 42篇 |
1989年 | 56篇 |
1988年 | 49篇 |
1987年 | 47篇 |
1986年 | 41篇 |
1985年 | 40篇 |
1984年 | 26篇 |
1983年 | 25篇 |
1982年 | 16篇 |
1981年 | 18篇 |
1979年 | 16篇 |
1978年 | 24篇 |
1974年 | 15篇 |
1971年 | 14篇 |
1969年 | 17篇 |
1968年 | 14篇 |
1966年 | 14篇 |
排序方式: 共有4754条查询结果,搜索用时 15 毫秒
101.
102.
Fumihiko Yasui Masayuki Sudoh Masaaki Arai Michinori Kohara 《Journal of medical virology》2013,85(2):241-249
The influence of the intracellular redox state on the hepatitis C virus (HCV) life cycle is poorly understood. This study demonstrated the anti‐HCV activity of 2,3‐dihydro‐5‐hydroxy‐2,2‐dipentyl‐4,6‐di‐tert‐butylbenzofuran (BO‐653), a synthetic lipophilic antioxidant, and examined whether BO‐653's antioxidant activity is integral to its anti‐HCV activity. The anti‐HCV activity of BO‐653 was investigated in HuH‐7 cells bearing an HCV subgenomic replicon (FLR3‐1 cells) and in HuH‐7 cells infected persistently with HCV (RMT‐tri cells). BO‐653 inhibition of HCV replication was also compared with that of several hydrophilic and lipophilic antioxidants. BO‐653 suppressed HCV replication in FLR3‐1 and RMT‐tri cells in a concentration‐dependent manner. The lipophilic antioxidants had stronger anti‐HCV activities than the hydrophilic antioxidants, and BO‐653 displayed the strongest anti‐HCV activity of all the antioxidants examined. Therefore, the anti‐HCV activity of BO‐653 was examined in chimeric mice harboring human hepatocytes infected with HCV. The combination treatment of BO‐653 and polyethylene glycol‐conjugated interferon‐α (PEG‐IFN) decreased serum HCV RNA titer more than that seen with PEG‐IFN alone. These findings suggest that both the lipophilic property and the antioxidant activity of BO‐653 play an important role in the inhibition of HCV replication. J. Med. Virol. 85:241–249, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
103.
Aiko Oka Masanori Kidoguchi Shin Kariya Tazuko Fujiwara Atsushi Yuta Hiromi Miyashita Takaya Higaki Yukiko Ogawa Kengo Kanai Sei-ichiro Makihara Takenori Haruna Jun Kunisawa Naoto Adachi Keisuke Koyama Rieko Ii Emiko Noguchi Shigeharu Fujieda Kazunori Nishizaki Mitsuhiro Okano 《Allergy》2021,76(8):2617-2620
104.
Risa Kanai Aya Miyagawa-Hayashino Yukiko Shishido-Hara Naoya Nakamura Ikoi Omatsu Yukiko Morinaga Yuji Shimura Junya Kuroda Tetsuya Imura Kyoko Itoh Eiichi Konishi 《Pathology international》2021,71(1):96-101
The case of 70-year-old man with mantle cell lymphoma (MCL) carrying t(11;14) translocation that relapsed as nodal lymphoma combining MCL and classic Hodgkin lymphoma (cHL) 9 years after autologous peripheral blood stem cell transplant (auto-PBSCT) is reported. Lymph nodes contained two separate areas of MCL and cHL-like components. Hodgkin and Reed–Sternberg (HRS)-like cells were accompanied by a prominent histiocyte background. HRS-like cells were CD5−, CD15+, CD20−, CD30+, PAX5+, Bob.1−, Oct2− and EBER+. The MCL component expressed cyclin D1 and SOX11, whereas cyclin D1 and SOX11 expressions were reduced and lost, respectively, in HRS-like cells. Polymerase chain reaction results showed a single clonal rearrangement of the IGH gene in MCL and cHL-like components. CCND1 break apart fluorescence in situ hybridization showed split signals in both MCL and HRS-like cells, suggesting that MCL and cHL-like components were clonally related. Acquisition of p53 expression and Epstein–Barr virus (EBV)-positivity was seen in HRS-like cells. The patient died of disease progression with elevated hepatobiliary enzymes. The autopsy showed both MCL and cHL-like components around the bile ducts, splenic white pulp and bone marrow. The two components were phenotypically distinct, but genetically related, suggesting that transformation of MCL to HRS-like cells during the course of MCL in association with EBV infection. 相似文献
105.
Hirota Yoshiaki Tawada Yasuyuki Komatsu Shigeki Watanabe Fumihiko 《Odontology / the Society of the Nippon Dental University》2021,109(1):157-167
Odontology - Oral scanners allow dental impressions to be taken in a short time without the use of an impression material. However, it has been noted that high impression accuracy cannot be... 相似文献
106.
Hiroo Takahashi Kaichiro Sawada Takatoshi Kakuta Takao Suga Kazuya Hanai Genta Kanai Satoshi Fujimura Noriyuki Sanechika Toshiro Terachi Masafumi Fukagawa Akira Saito 《Journal of artificial organs》2013,16(3):368-375
Bioartificial renal tubule devices (BTD) use cell therapy to improve conditions commonly observed in recipients of artificial kidneys for treatment of kidney diseases. We previously reported significant improvement of the condition of acute kidney injury (AKI) animals after treatment with BTD prepared with lifespan-extended human renal proximal tubular cells (hRPTEC). However, a major obstacle to use of BTD for patients is their biological safety, because hRPTEC are cultured in medium containing fetal calf serum. To establish the biological safety of BTD, we prepared BTD with lifespan-extended hRPTEC cultured in a newly developed serum-free medium and compared these with BTD prepared with hRPTEC cultured in serum-containing conventional medium. Lifespan-extended hRPTEC cultured in serum-free medium (hRPTEC-SFM) can proliferate similar to hRPTEC cultured in serum-containing conventional medium (hRPTEC-CM). Comparison of leakage and of reabsorption of small molecules for BTD prepared with hRPTEC-SFM (BTD-SFM) with those for our previous BTD prepared with hRPTEC-CM (BTD-CM) showed transportation in these two types of BTD was almost identical. When AKI goats were treated with BTD-SFM for 26 h, increase of survival time and reduction of cytokine expression in blood cells were almost same as for AKI goats treated with BTD-CM. Quantification of the expression of some genes of hRPTEC in BTD revealed significant changes during BTD treatment for AKI goats. In conclusion, lifespan-extended hRPTEC-SFM work as well as hRPTEC-CM, and the biological safety of BTD for patients could be elevated without loss of function by preparation from hRPTEC-SFM. 相似文献
107.
Takamura Yoshiaki Motoyama Yasushi Takatani Tsunenori Takeshima Yasuhiro Matsuda Ryosuke Tamura Kentaro Yamada Shuichi Nishimura Fumihiko Nakagawa Ichiro Park Young-Su Nakase Hiroyuki 《Journal of clinical monitoring and computing》2021,35(5):1055-1062
Journal of Clinical Monitoring and Computing - Balloon test occlusion (BTO) is a useful examination for evaluating ischemic tolerance to internal carotid artery (ICA) occlusion. The aim of this... 相似文献
108.
Accompanying artery of sciatic nerve as recipient vessel for free‐flap transfer: A computed tomographic angiography study and case reports
下载免费PDF全文
![点击此处可从《Microsurgery》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shimpei Miyamoto M.D. Yutaka Fukunaga M.D. Masahide Fujiki M.D. Fumihiko Nakatni M.D. Yoshikazu Tanzawa M.D. Minoru Sakuraba M.D. 《Microsurgery》2015,35(4):284-289
Suitable recipient vessels for free‐flap transfer are hard to find in the posterior thigh. To investigate the versatility of accompanying artery of sciatic nerve as a recipient vessel in this region, we performed computed tomographic angiographic study of 20 consecutive healthy thighs in 10 patients. The presence and internal diameter of the accompanying artery were studied. The accompanying artery of the sciatic nerve was present in 11 thighs (55%) and the internal diameter of the artery at the mid‐thigh level ranged from 2.1 to 3.2 mm. We used this artery as a recipient vessel for free flaps transferred to reconstruct extensive thigh defects in three patients with sarcomas. In all patients the flaps survived without vascular compromise. No sensory or motor dysfunction in the sciatic nerve distribution occurred in any patients. We believe that the accompanying artery of the sciatic nerve may be a recipient vessel for free‐flap transfer in selected patients. © 2014 Wiley Periodicals, Inc. Microsurgery 35:284–289, 2015. 相似文献
109.
Satoshi Kanai Taku Miyashita Tatsumi Tada 《International Journal on Interactive Design and Manufacturing》2007,1(3):175-179
This paper proposes a high-level architecture-based multi-disciplinary distributed simulation environment for designing mechatronic
systems. In the system, commercial off-the-shelf simulators can communicate each other via real-time-infrastructure to realize
software-in-the-loop simulation. Moreover, hardware prototypes can also participate in a part of the distributed simulation
environment which enable us hardware-in-the-loop simulation. Effectiveness was verified by applying the environment to mechatronic
system design of an automotive power-window and an omni-directional electric wheel chair. 相似文献
110.
A lipoprotein lipase activator,NO-1886 prevents impaired endothelium-dependent relaxation of aorta caused by exercise in aged rats 总被引:2,自引:0,他引:2
Kusunoki M Tsutsumi K Hara T Ogawa H Nakamura T Miyata T Sakakibara F Fukuzawa Y Suga T Kakumu S Nakaya Y 《Experimental gerontology》2002,37(7):891-896
Exercise decreases plasma total cholesterol and triglycerides, and simultaneously, increases high density lipoprotein (HDL) cholesterol. As a result, exercise is believed to aid in preventing atherosclerosis. However, we do not know whether exercise protects against the development of atherosclerosis in the elderly. The aim of this study was to ascertain whether the lipoprotein lipase activator NO-1886 had an effect on the prevention of atherosclerosis in aged rats which undergo exercise. Exercise for 3 months did not affect plasma lipids but decreased the accumulation of visceral fat in 2-year-old rats (aged rat). Exercise also resulted in an elevation of plasma lipid peroxide (LPO) levels and impaired the endothelium-dependent relaxation of the thoracic aorta caused by acetylcholine in aged rats. On the other hand, NO-1886 decreased plasma triglycerides and increased HDL cholesterol and suppressed the elevation of plasma LPO levels caused by exercise. Furthermore, NO-1886 prevented impaired endothelium-dependent relaxation caused by exercise. In summary, the results of our study indicate that exercise may cause impaired endothelium-dependent relaxation by elevation of LPO in aged rats, and that NO-1886 prevents this impaired endothelium-dependent relaxation of aorta by reducing plasma triglycerides, elevating HDL cholesterol, and suppressing the elevation of plasma LPO caused by exercise. 相似文献