全文获取类型
收费全文 | 1120篇 |
免费 | 106篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 23篇 |
妇产科学 | 12篇 |
基础医学 | 172篇 |
口腔科学 | 20篇 |
临床医学 | 156篇 |
内科学 | 205篇 |
皮肤病学 | 28篇 |
神经病学 | 55篇 |
特种医学 | 92篇 |
外科学 | 192篇 |
综合类 | 54篇 |
一般理论 | 1篇 |
预防医学 | 81篇 |
眼科学 | 20篇 |
药学 | 71篇 |
中国医学 | 5篇 |
肿瘤学 | 83篇 |
出版年
2023年 | 10篇 |
2022年 | 18篇 |
2021年 | 45篇 |
2020年 | 32篇 |
2019年 | 22篇 |
2018年 | 40篇 |
2017年 | 27篇 |
2016年 | 32篇 |
2015年 | 27篇 |
2014年 | 34篇 |
2013年 | 51篇 |
2012年 | 62篇 |
2011年 | 67篇 |
2010年 | 46篇 |
2009年 | 41篇 |
2008年 | 57篇 |
2007年 | 100篇 |
2006年 | 46篇 |
2005年 | 68篇 |
2004年 | 34篇 |
2003年 | 32篇 |
2002年 | 38篇 |
2001年 | 22篇 |
2000年 | 32篇 |
1999年 | 20篇 |
1998年 | 17篇 |
1997年 | 15篇 |
1996年 | 13篇 |
1995年 | 9篇 |
1994年 | 17篇 |
1993年 | 26篇 |
1992年 | 24篇 |
1991年 | 29篇 |
1990年 | 12篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1983年 | 8篇 |
1982年 | 8篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1977年 | 3篇 |
1975年 | 3篇 |
1972年 | 3篇 |
1968年 | 1篇 |
1924年 | 1篇 |
排序方式: 共有1276条查询结果,搜索用时 0 毫秒
91.
Hutabarat Sonya Natasha Domazetovska Ana Ziochos Helen Hassett Geraldine Foo Hong 《European journal of clinical microbiology & infectious diseases》2023,42(5):665-667
European Journal of Clinical Microbiology & Infectious Diseases - 相似文献
92.
93.
OBJECTIVE: To investigate the long-term effects of shunting on neurologic outcome of syringomyelia, a complication of spinal cord injury (SCI). DESIGN: Retrospective data collection using telephonic survey. SETTING: University based medical center. PARTICIPANTS: Eight of 15 patients who had shunts placed between 1976 and 1999. INTERVENTIONS: Review of clinical records and self-reported telephone interview. MAIN OUTCOMES MEASURES: Initial clinical presentation, recovery after shunt placement, and subsequent neurologic status were recorded. Patients were asked to rate symptomatic improvement after surgery on a 100-point analog scale; they were also asked whether they would have the surgery again. RESULTS: Presenting symptoms were weakness in all 8 patients, pain in 5 patients, and numbness in 5 patients. After shunting, 6 patients had improved strength, all had less pain, and 2 had less numbness. Six patients experienced neurologic decline an average of 2 years after shunt placement, 3 because of shunt failure, 2 from a new syrinx, and 1 from both shunt failure and new syrinx. Two of the 3 patients who underwent second shunt placements for a new syrinx had full neurologic recovery. Six patients said they would repeat the shunting procedure if necessary, 1 was uncertain, and 1 would not. CONCLUSION: Initial improvements noted after shunting provide long-lasting effects, even though many patients may need a second procedure. Less pain and improved strength are more significant than decreased numbness. 相似文献
94.
95.
William T.H. Lim Ean H. Ooi Ji J. Foo Kwan H. Ng Jeannie H.D. Wong Sook S. Leong 《Ultrasound in medicine & biology》2021,47(8):2033-2047
Early detection of chronic kidney disease is important to prevent progression of irreversible kidney damage, reducing the need for renal transplantation. Shear wave elastography is ideal as a quantitative imaging modality to detect chronic kidney disease because of its non-invasive nature, low cost and portability, making it highly accessible. However, the complexity of the kidney architecture and its tissue properties give rise to various confounding factors that affect the reliability of shear wave elastography in detecting chronic kidney disease, thus limiting its application to clinical trials. The objective of this review is to highlight the confounding factors presented by the complex properties of the kidney, in addition to outlining potential mitigation strategies, along with the prospect of increasing the versatility and reliability of shear wave elastography in detecting chronic kidney disease. 相似文献
96.
Chronic neurobehavioural effects of toluene 总被引:5,自引:0,他引:5
Neurobehavioural tests were undertaken by 30 female workers exposed to toluene and matched controls with low occupational exposure to toluene. The environmental air levels (TWA) of toluene was 88 ppm for the exposed workers and 13 ppm for the controls. The toluene in blood concentrations for the exposed workers was 1.25 mg/l and for the controls 0.16 mg/l. Statistically significant differences between workers exposed to toluene and controls in neurobehavioural tests measuring manual dexterity (grooved peg board), visual scanning (trail making, visual reproduction, Benton visual retention, and digit symbol), and verbal memory (digit span) were observed. Further, the performance at each of these tests was related to time weighted average exposure concentrations of air toluene. The workers exposed to toluene had no clinical symptoms or signs. The question arises as to whether these impairments in neurobehavioural tests are reversible or whether they could be a forerunner of more severe damage. 相似文献
97.
98.
Kitano T Okumura T Nishizawa M Liew FY Seki T Inoue K Ito S 《Journal of hepatology》2002,36(6):759-765
BACKGROUND/AIMS: Production of nitric oxide (NO) in the liver is believed to be a critical factor for carbohydrate and energy metabolism in endotoxin shock. The present study focuses on the involvement of NO produced by inducible nitric oxide synthase (iNOS) in glycogen synthesis and energy metabolism stimulated by insulin.METHODS: Primary hepatocytes prepared from wild-type and iNOS knockout (iNOS(-/-)) mice were employed.RESULTS: Incubation of wild-type hepatocytes with a combination of cytokines (interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma) and lipopolysaccharide (cytokines/LPS) inhibited insulin-stimulated glycogen synthesis and adenosine triphosphate (ATP) increase, and decreased the ketone body ratio (KBR) at 8-12 h, concomitant with expression of iNOS protein and NO production. While the glycogen synthesis was suppressed by cytokines/LPS, reduction of the ATP increase and a decrease in KBR by cytokines/LPS were not observed in iNOS(-/-) hepatocytes. Further, N(G)-monomethyl-L-arginine, a NOS inhibitor, reversed the inhibition of ATP increase and decrease in KBR by cytokines/LPS, but not the inhibition of glycogen synthesis. Conversely, addition of S-nitroso-N-acetylpenicillamine, a NO donor, inhibited the insulin-stimulated ATP increase synthesis in iNOS(-/-) hepatocytes, but not the insulin-stimulated glycogen synthesis.CONCLUSIONS: These results demonstrate that NO mediates the suppression of insulin-stimulated energy metabolism, but not glycogen synthesis, in cytokines/LPS-treated hepatocytes. 相似文献
99.
Objectives. Monitoring arterial distensibility changes is important to understand the cardiovascular status of patient. Pulse transit
time (PTT), which is an inverse equivalent of pulse wave velocity (PWV), has shown its potential in such studies. However,
its methodological approach in using an electrocardiogram and a peripheral photoplethysmography (PPG) is limited due to the
inclusion of pre-ejection period (PEP) in its computation. Previous studies have suggested the using the transit time difference
between two peripheral measuring sites (PTT-D) instead. However, it requires two medical instruments and may not be efficient
in terms of equipment utility, especially in prolonged clinical studies. Methods. Postural changes are known to cause complex haemodynamics adaptation and thereby affecting transit time measurements. A customised
dual-channel PPG system based on discrete electronic devices was constructed to evaluate against conventional peripheral-based
PTT. 10 healthy adults (7 male; mean age 27.0 yr) were recruited to assess the differences observed in PTT and PTT-D during
two postural change test activities. Results. PTT-D derived from the customised PPG system registered 43.3± 5.6 ms and − 31.1± 3.8 msrelativechangesforthetworegulatedactivitieswhileconventionalPTTrecorded 43.6± 10.3 msand -31.0±m 6.5 msrespectively. Theformermayhavesimilarresultsbuthavesignificantlylowervariance (< EmphasisType =Italic
p </Emphasis 0.05). Conclusions. Findings herein suggest that PTT-D derived from the customised PPG system shows potential. It can be used as an alternative
to conventional peripheral-based PTT and possibly as a direct assessment of arterial distensibility or PWV variations as it
does not include PEP in its time-related computations. 相似文献
100.
Keng-Wei Hu Yu-Hui Lu Hung-Jung Lin How-Ran Guo Ning-Ping Foo 《The Journal of emergency medicine》2012